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Chemical Structure| 1160995-45-8 Chemical Structure| 1160995-45-8

Structure of 1160995-45-8

Chemical Structure| 1160995-45-8

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Product Details of [ 1160995-45-8 ]

CAS No. :1160995-45-8
Formula : C6H2Cl2N4O2
M.W : 233.01
SMILES Code : O=[N+](C1=CN2N=C(Cl)N=C(Cl)C2=C1)[O-]
MDL No. :MFCD12400797
InChI Key :UILXDKCIJUPNOF-UHFFFAOYSA-N
Pubchem ID :57345879

Safety of [ 1160995-45-8 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of [ 1160995-45-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1160995-45-8 ]

[ 1160995-45-8 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 1160995-45-8 ]
  • [ 2247-88-3 ]
  • 2-chloro-N-(3-fluoropyridin-4-yl)-6-nitropyrrolo[2,1-f][1,2,4]triazin-4-amine [ No CAS ]
YieldReaction ConditionsOperation in experiment
75% In tetrahydrofuran; at 20℃; for 1h; To a 100 mL flask was added 2,4-dichloro-6-nitropyrrolo[2,1-J][1,2,4]triazine (1 g, 4.29 mmol) <strong>[2247-88-3]3-fluoropyridin-4-amine</strong> (0.48 1 g, 4.29 mmol), THF (20 mL) and stirred at room temperature for 1 h. An aliquot of the reaction mixture was diluted with methanoland analyzed by LCMS to ensure complete conversion. The reaction mixture was evaporated and the residue was basified using 10percent sodium bicarbonate solution. The aquoeus layer was extracted with ethyl acetate, washed with water, brine, dried over sodium sulfate and concentrated to get 2-chloro-N-(3-fluoropyridin-4-yl)-6- nitropyrrolo[2,1-J][1,2,4]triazin-4-amine (1 g, 3.24 mmol, 75 percent yield) as a yellow solid.LCMS m/z 309.0 (M+H); rt 2.2 mm; Conditions E.
 

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