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Chemical Structure| 1162680-84-3 Chemical Structure| 1162680-84-3

Structure of 1162680-84-3

Chemical Structure| 1162680-84-3

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Product Details of [ 1162680-84-3 ]

CAS No. :1162680-84-3
Formula : C9H8BrN3O
M.W : 254.08
SMILES Code : CC(NC1=CN2C=C(Br)C=CC2=N1)=O

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Application In Synthesis of [ 1162680-84-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1162680-84-3 ]

[ 1162680-84-3 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 1162680-84-3 ]
  • [ 452972-11-1 ]
  • N-(6-(2-chloropyridin-3-yl)imidazo[1,2-a]pyridin-2-yl)acetamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
59.4% With tetrakis(triphenylphosphine) palladium(0); sodium carbonate; In 1,4-dioxane; water; at 100℃; for 12h;Inert atmosphere; To a stirred solution of compound 9A (reference: US 2009/0163489 Al) (0.3 15 g, 1.24 mmol) and 2-chloro-3-(4,4,5 ,5 -tetramethyl- 1,3 ,2-dioxaborolan-2-yl)pyridine (Reference WO 2015157093 Al/WO 2015044172 Al/WO 2014055955 Al) (0.445, 1.86 mmol) in 1,4- dioxane (9 mL) and water (3 mL) was added Na2CO3 (0.3 94 g, 3.72 mmol). The reaction mixture was degassed for 3 mm. and then to it was added Pd(PPh3)4 (0. 143g, 0.124 mmol), and the resultant mixture was heated at 100 C for 12 h. The reaction mixture was then filtered through a Celite pad, the filter cake washed with ethyl acetate and the combined filtrate evaporated under reduced pressure to give the cmde compound. It was purified via silica gel chromatography (24 g Redisep column, eluted with 60 % ethyl acetate in petroleum ether) to furnish N-(6-(2-chloropyridin-3-yl)imidazo[ 1 ,2-ajpyridin-2-yl)acetamide 9B (211 mg, 0.736 mmol, 59.4 % yield) as a light yellow solid. LCM5: m/z = 385.0 [M+Hf?; ret. time 1.49 mm; condition C.
 

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