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[ CAS No. 116436-10-3 ]

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3d Animation Molecule Structure of 116436-10-3

Chemical Structure| 116436-10-3

Chemical Structure| 116436-10-3

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Quality Control of [ 116436-10-3 ]

COA NMR CNMR HPLC LC-MS

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SDS Specification

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Product Details of [ 116436-10-3 ]

CAS No. :	116436-10-3	MDL No. :	MFCD11520466
Formula :	C₉H₁₀BrNO	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	HCSKOFDCUTVQKW-UHFFFAOYSA-N
M.W :	228.09 g/mol	Pubchem ID :	14233594
Synonyms :

Calculated chemistry of [ 116436-10-3 ]

Physicochemical Properties

Num. heavy atoms :	12
Num. arom. heavy atoms :	6
Fraction Csp3 :	0.22
Num. rotatable bonds :	2
Num. H-bond acceptors :	1.0
Num. H-bond donors :	1.0
Molar Refractivity :	53.42
TPSA :	29.1 Å²

Pharmacokinetics

GI absorption :	High
BBB permeant :	Yes
P-gp substrate :	No
CYP1A2 inhibitor :	Yes
CYP2C19 inhibitor :	No
CYP2C9 inhibitor :	No
CYP2D6 inhibitor :	No
CYP3A4 inhibitor :	No
Log Kp (skin permeation) :	-6.36 cm/s

Lipophilicity

Log Po/w (iLOGP) :	2.23
Log Po/w (XLOGP3) :	1.88
Log Po/w (WLOGP) :	2.53
Log Po/w (MLOGP) :	2.56
Log Po/w (SILICOS-IT) :	2.52
Consensus Log Po/w :	2.34

Druglikeness

Lipinski :	0.0
Ghose :	None
Veber :	0.0
Egan :	0.0
Muegge :	0.0
Bioavailability Score :	0.55

Water Solubility

Log S (ESOL) :	-2.68
Solubility :	0.48 mg/ml ; 0.00211 mol/l
Class :	Soluble
Log S (Ali) :	-2.11
Solubility :	1.76 mg/ml ; 0.00771 mol/l
Class :	Soluble
Log S (SILICOS-IT) :	-4.03
Solubility :	0.0212 mg/ml ; 0.0000929 mol/l
Class :	Moderately soluble

Medicinal Chemistry

PAINS :	0.0 alert
Brenk :	0.0 alert
Leadlikeness :	1.0
Synthetic accessibility :	1.6

Safety of [ 116436-10-3 ]

Signal Word:	Warning	Class:	N/A
Precautionary Statements:	P280-P305+P351+P338	UN#:	N/A
Hazard Statements:	H302	Packing Group:	N/A
GHS Pictogram:

Application In Synthesis of [ 116436-10-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Upstream synthesis route of [ 116436-10-3 ]
Downstream synthetic route of [ 116436-10-3 ]

[ 116436-10-3 ] Synthesis Path-Upstream 1~2

1
[ 116436-10-3 ]
[ 114306-17-1 ]

Reference： [1] Justus Liebigs Annalen der Chemie, 1912, vol. 388, p. 34

2
[ 116436-10-3 ]
[ 20776-50-5 ]

Reference： [1] Collection of Czechoslovak Chemical Communications, 1935, vol. 7, p. 436,443
[2] Justus Liebigs Annalen der Chemie, 1912, vol. 388, p. 34

[ 116436-10-3 ] Synthesis Path-Downstream 1~28

1
[ 116436-10-3 ]
[ 101861-53-4 ]

Yield	Reaction Conditions	Operation in experiment
95%	With pyridine; potassium permanganate In water at 20 - 90℃; for 4h;	11B Example 11B 2-ACETYLAMINO-4-BROMO-BENZOIC acid To a solution of Example 11A (0.372 g, 1.63 mmol) in pyridine (6 mL) and HO (6 mL) was added KMnO4 (1.03 g, 6.52 mmol) in 2 portions at room temperature. The reaction mixture was heated to 90 °C for 4 hours and immediately filtered. The filter cake was rinsed with hot H20. The filtrate was concentrated and treated with H2O. The solid material was filtered and filtrate acidified with 10% HCL until pH=3. The white precipitate was filtered, rinsed with H20, and dried in a vacuum oven to give 0.398 g (95%) of the desired product as white solid. MS (DCI/NH3) m/z: 257.9 (M+H) +, 259.9 (M+2+H) + ; 1H NMR (300 MHz, CD30D) 8 2.20 (s, 3 H), 7.30 (dd, J=8.48, 2.03 Hz, 1 H), 7.97 (d, J=8.48 Hz, 1 H), 8.84 (d, J=2.03 Hz, 1 H).
	With potassium permanganate; water; magnesium sulfate at 80℃;
	With potassium permanganate; water; magnesium sulfate

Reference： [1]Current Patent Assignee: ABBVIE INC - WO2004/80973, 2004, A1 Location in patent: Page 51-52
[2]Friedlaender; Bruckner; Deutsch [Justus Liebigs Annalen der Chemie, 1912, vol. 388, p. 34]
[3]Frejka; Vymetal [Collection of Czechoslovak Chemical Communications, 1935, vol. 7, p. 436,443]

2
[ 39478-78-9 ]
[ 108-24-7 ]
[ 116436-10-3 ]

Yield	Reaction Conditions	Operation in experiment
	With sulfuric acid

Reference： [1]Frejka; Vymetal [Collection of Czechoslovak Chemical Communications, 1935, vol. 7, p. 436,443]

3
[ 116436-10-3 ]
[ 286461-70-9 ]

Yield	Reaction Conditions	Operation in experiment
	With chlorosulfonic acid

Reference： [1]Gupta; Phull, Manjinder Singh [Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1996, vol. 35, # 9, p. 967 - 969]

Yield	Reaction Conditions	Operation in experiment
	Rk. mit 1) KMnO4, 2) HCl - > 4-Brom-anthranilsaeure;

Yield	Reaction Conditions	Operation in experiment
	o-Acetamino-toluol, Br2;

Yield	Reaction Conditions	Operation in experiment
	With sulfuric acid

7
[ 7664-93-9 ]
1-(5-bromo-2-methyl-phenyl)-ethanone-⁽¹⁾-<i>seqtrans</i>-oxime [ No CAS ]
[ 116436-10-3 ]

Reference： [1]Borsche; Herbert [Justus Liebigs Annalen der Chemie, 1941, vol. 546, p. 277,291]

8
[ 116436-10-3 ]
4-Amino-2-bromo-5-methyl-N-(4-phenyl-thiazol-2-yl)-benzenesulfonamide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 3 steps 1: chlorosulphonic acid 2: 50 percent / pyridine, acetic anhydride / 2 h 3: 55 percent / acetic acid / H₂O / Heating; 4-5 h

Reference： [1]Gupta; Phull, Manjinder Singh [Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1996, vol. 35, # 9, p. 967 - 969]

9
[ 116436-10-3 ]
2-(4-Amino-2-bromo-5-methyl-benzenesulfonylamino)-4-methyl-thiazole-5-carboxylic acid ethyl ester [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 3 steps 1: chlorosulphonic acid 2: 45 percent / pyridine, acetic anhydride / 2 h 3: 50 percent / acetic acid / H₂O / Heating; 4-5 h

Reference： [1]Gupta; Phull, Manjinder Singh [Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1996, vol. 35, # 9, p. 967 - 969]

10
[ 116436-10-3 ]
N-[5-Bromo-2-methyl-4-(4-phenyl-thiazol-2-ylsulfamoyl)-phenyl]-acetamide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: chlorosulphonic acid 2: 50 percent / pyridine, acetic anhydride / 2 h

Reference： [1]Gupta; Phull, Manjinder Singh [Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1996, vol. 35, # 9, p. 967 - 969]

11
[ 116436-10-3 ]
2-(4-Acetylamino-2-bromo-5-methyl-benzenesulfonylamino)-4-methyl-thiazole-5-carboxylic acid ethyl ester [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: chlorosulphonic acid 2: 45 percent / pyridine, acetic anhydride / 2 h

Reference： [1]Gupta; Phull, Manjinder Singh [Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1996, vol. 35, # 9, p. 967 - 969]

12
[ 116436-10-3 ]
[ 20776-50-5 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: potassium permanganate; magnesium sulfate; water 2: aqueous sulfuric acid
	Multi-step reaction with 2 steps 1: potassium permanganate; water; magnesium sulfate / 80 °C 2: diluted sulfuric acid

Reference： [1]Frejka; Vymetal [Collection of Czechoslovak Chemical Communications, 1935, vol. 7, p. 436,443]
[2]Friedlaender; Bruckner; Deutsch [Justus Liebigs Annalen der Chemie, 1912, vol. 388, p. 34]

13
[ 116436-10-3 ]
[ 859184-22-8 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 3 steps 1: potassium permanganate; magnesium sulfate; water 2: aqueous sulfuric acid 3: sulfuric acid

Reference： [1]Frejka; Vymetal [Collection of Czechoslovak Chemical Communications, 1935, vol. 7, p. 436,443]

14
[ 116436-10-3 ]
2-amino-4-bromo-benzoic acid-(2-diethylamino-ethyl ester) [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 4 steps 1: potassium permanganate; magnesium sulfate; water 2: aqueous sulfuric acid 3: sulfuric acid

Reference： [1]Frejka; Vymetal [Collection of Czechoslovak Chemical Communications, 1935, vol. 7, p. 436,443]

15
[ 60956-26-5 ]
[ 116436-10-3 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: iron; aqueous hydrochloric acid 2: sulfuric acid

Reference： [1]Frejka; Vymetal [Collection of Czechoslovak Chemical Communications, 1935, vol. 7, p. 436,443]

16
[ 116436-10-3 ]
[ 114306-17-1 ]

Reference： [1]Justus Liebigs Annalen der Chemie,1912,vol. 388,p. 34

17
[ 116436-10-3 ]
[ 244256-21-1 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 3 steps 1: potassium permanganate; water; magnesium sulfate / 80 °C 2: diluted sulfuric acid 3: natrium carbonate

Reference： [1]Friedlaender; Bruckner; Deutsch [Justus Liebigs Annalen der Chemie, 1912, vol. 388, p. 34]

18
[ 39478-78-9 ]
[ 75-36-5 ]
[ 116436-10-3 ]

Yield	Reaction Conditions	Operation in experiment
61%	With pyridine; at 0 - 20℃; for 1h;	To a solution of 3-BROMO-6-METHYLANILINE (1.00 g, 5.37 mmol) in pyridine (8 ML) was added acetyl chloride (0.76 mL, 10.7 mmol) at 0 C. The reaction mixture was stirred at room temperature for 1 hour and concentrated. The residue was extracted with EtOAc, washed with 5% citric acid, dried over MgS04, concentrated, and triturated with ether to give 0.750 g (61%) of the desired product as off-white crystal. MS (DCI/NH3) m/z : 227. 9 (M+H) +, 229. 9 (M+2+H) +; 1H NMR (300 MHz, CDC13) o 2.21 (s, 6 H), 6.90 (m, 1 H), 7. Q4 (d, J=8. 14 Hz, 1 H), 7. 20 (d, J=7. 80 Hz, 1 H), 8. 06 (s, 1 H).

Reference： [1]Patent: WO2004/80973,2004,A1 .Location in patent: Page 51

19
[ 6358-77-6 ]
[ 75-36-5 ]
[ 116436-10-3 ]

Yield	Reaction Conditions	Operation in experiment
93.5%	With triethylamine; In dichloromethane; at 20℃; for 24h;	Roundbottom flask is charged with 5-bromo-2-methylaniline( 400.00 mg; 2.15 mmol; 1 .0 eg.), triethylamine ( 330.76 mL; 2.36 mmol; 1.1 eq.) and anhydrous dichloromethane (12 mL). Acetyl chloride ( 185.64 mg; 2.36 mmol; 1.1 eq.) is then added dropwise and reaction mixture is stirred at room temperature for 24h. After this time diethyl ether (24 mL) is added and mixture is washed with saturated aqueous solution of ammonium chloride (2x20 mL) and brine (2x20 mL). Organic layer is then dried over anhydrous Na2SO4 overnight. The second organic solvent is evaporated to afford N-(5- bromo-2-methylphenyl)acetamide (513.20 mg; yield 93.5 %; 89.3 % by UPLC) as brown solid.

Reference： [1]Patent: WO2016/180536,2016,A1 .Location in patent: Page/Page column 312

20
[ 116436-10-3 ]
[ 1157928-89-6 ]

Yield	Reaction Conditions	Operation in experiment
69.3%	With lithium aluminium tetrahydride In tetrahydrofuran at 20℃; for 24h;	Roundbottom flask is charged with N-(5-bromo-2-methylphenyl)acetamide (Intermediate 137) ( 513.20 mg; 2.01 mmol; 1 .0 eq.) and anhydrous tetrahydrofuran (17.96 mL). RM is cooled down to 0 °C and lithium aluminium hydride 2.0 M solution in tetrahydrofuran ( 2.21 mL; 4.42 mmol; 2.2 eq.) is added in this temperature while RM is stirred. RM is allowed to warmed up to room temperature. RM is heated and stirred at reflux for 24 h. After this time RM is cooled to room temperature and water is added to RM. Then consecutively 5M aqueous solution of NaOH (5 mL) and water (10 mL). RM is stirred for 30 minutes and then extracted with EtOAc ( 3x 0 mL). Organic solvents are then collected, combined and washed with brine (2 times). Then organic solvents are dried over Na2SO4 overnight. After this organic solvent is evaporated to afford 5-bromo-N-ethyl-2-methylaniline ( 313.90 mg; yield 69.3 %; 95.0 % by UPLC) as a beige semisolid.

Reference： [1]Current Patent Assignee: SELVITA S.A. - WO2016/180536, 2016, A1 Location in patent: Page/Page column 313

21
[ 116436-10-3 ]
5-bromo-N-ethyl-N,2-dimethylaniline [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1.1: lithium aluminium tetrahydride / tetrahydrofuran / 24 h / 20 °C 2.1: acetic acid; formaldehyd / 0.17 h / 20 °C 2.2: 1 h / 20 °C

Reference： [1]Current Patent Assignee: SELVITA S.A. - WO2016/180536, 2016, A1

22
[ 621-38-5 ]
[ 112359-25-8 ]
[ 116436-10-3 ]

Reference： [1]Organic Letters,2018,vol. 20,p. 676 - 679

23
[ 591-19-5 ]
[ 116436-10-3 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: 0 - 25 °C 2: copper(II) acetate monohydrate; palladium diacetate; trifluoroacetic acid / 1,2-dichloro-ethane / 6 h / 50 °C / Sealed tube

Reference： [1]Simkó, Dániel Cs.; Elekes, Péter; Pázmándi, Vivien; Novák, Zoltán [Organic Letters, 2018, vol. 20, # 3, p. 676 - 679]

24
[ 116436-10-3 ]
[ 73183-34-3 ]
C₁₅H₂₂BNO₃ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
91%	With bis-triphenylphosphine-palladium(II) chloride; potassium acetate In 1,4-dioxane at 100℃; for 12h; Inert atmosphere;	B. Preparation of substrates: General procedure A General procedure: A 100 mL round bottomed flask was charged with a stir bar, Pd(PPh3)2Cl2 (0.18 g, 5 mol%), B2Pin2 (6.0 mmol, 1.2 equiv), aryl bromides 1S1 (5.0 mmol, 1.0 equiv), AcOK (20 mmol, 4.0 equiv) in 40.0 mL anhydrous 1,4-dioxane. The mixture was degassed with nitrogen and heated at 100 °C for 12 hours. The mixture was diluted with EtOAc, and the organic layer was washed with saline, dried over anhydrous Na2SO4 and filtered. The crude product was then chromatographed on silica gel to afford the desired compound 1S2. A 100 mL round bottom flask with a stir bar was fitted with a rubber septum and flame dried under high vacuum. The flask was purged with argon and charged with Pd(PPh3)4 (0.34 g, 6 mol%), K2CO3 (20.0 mmol, 4.0 equiv), 1-bromo-2-naphthol derivatives (5.0 mmol, 1.0 equiv), 1S2 (6.0 mmol, 1.2 equiv), followed by addition of 50.0 mL deoxygenated 1,4-dioxane and 10.0 mL deoxygenated water. The mixture was stirred at 100 °C until the reaction was judged to be completed by TLC analysis. Water was added and extracted with EtOAc. The organic phase was dried over anhydrous MgSO4 and concentrated under reduced pressure. The residue was then chromatographed on neutral Al2O3 to afford the desired compound 1. 1-bromo-2-naphthol derivatives were prepared according to the literature methods [2].

Reference： [1]Hao, Jiamao; Ge, Yicong; Yang, Liuqing; Wang, Jing; Luan, Xinjun [Tetrahedron Letters, 2021, vol. 71]

25
[ 116436-10-3 ]
N-(5-(2-hydroxynaphthalen-1-yl)-2-methylphenyl)acetamide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: bis-triphenylphosphine-palladium(II) chloride; potassium acetate / 1,4-dioxane / 12 h / 100 °C / Inert atmosphere 2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / 1,4-dioxane; water / 12 h / 100 °C / Inert atmosphere

Reference： [1]Hao, Jiamao; Ge, Yicong; Yang, Liuqing; Wang, Jing; Luan, Xinjun [Tetrahedron Letters, 2021, vol. 71]

26
[ 116436-10-3 ]
N-(5-methyl-2'-oxo-2,3-diphenyl-2'H-spiro[indene-1,1'-naphthalen]-4-yl)acetamide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 3 steps 1: bis-triphenylphosphine-palladium(II) chloride; potassium acetate / 1,4-dioxane / 12 h / 100 °C / Inert atmosphere 2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / 1,4-dioxane; water / 12 h / 100 °C / Inert atmosphere 3: potassium acetate; [ruthenium(II)(η⁶-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]₂; copper diacetate; silver hexafluoroantimonate / tetrahydrofuran / 12 h / 130 °C / Inert atmosphere; Sealed tube; Glovebox

Reference： [1]Hao, Jiamao; Ge, Yicong; Yang, Liuqing; Wang, Jing; Luan, Xinjun [Tetrahedron Letters, 2021, vol. 71]

27
[ 591-50-4 ]
[ 116436-10-3 ]
N-(5-bromo-2-methylphenyl)-N-(4-iodophenyl)acetamide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
69%	With 1,1,1,3',3',3'-hexafluoro-propanol; 3-chloro-benzenecarboperoxoic acid at 0℃; for 6h; Sealed tube;

Reference： [1]Chen, Yujie; Huang, Zhibin; Jiang, Yaqiqi; Shu, Sai; Yang, Shan; Shi, Da-Qing; Zhao, Yingsheng [Journal of Organic Chemistry, 2021, vol. 86, # 12, p. 8226 - 8235]

28
[ 116436-10-3 ]
5-bromo-N-(4-iodophenyl)-2-methylaniline [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: 3-chloro-benzenecarboperoxoic acid; 1,1,1,3',3',3'-hexafluoro-propanol / 6 h / 0 °C / Sealed tube 2: sodium hydroxide / ethanol / 1 h / 100 °C / Sealed tube

Reference： [1]Chen, Yujie; Huang, Zhibin; Jiang, Yaqiqi; Shu, Sai; Yang, Shan; Shi, Da-Qing; Zhao, Yingsheng [Journal of Organic Chemistry, 2021, vol. 86, # 12, p. 8226 - 8235]

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P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Ghs Hazard Statements

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere