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Chemical Structure| 116436-10-3 Chemical Structure| 116436-10-3

Structure of 116436-10-3

Chemical Structure| 116436-10-3

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Product Details of [ 116436-10-3 ]

CAS No. :116436-10-3
Formula : C9H10BrNO
M.W : 228.09
SMILES Code : CC(NC1=CC(Br)=CC=C1C)=O
MDL No. :MFCD11520466
Boiling Point : No data available
InChI Key :HCSKOFDCUTVQKW-UHFFFAOYSA-N
Pubchem ID :14233594

Safety of [ 116436-10-3 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302
Precautionary Statements:P280-P305+P351+P338

Application In Synthesis of [ 116436-10-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 116436-10-3 ]

[ 116436-10-3 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 6358-77-6 ]
  • [ 75-36-5 ]
  • [ 116436-10-3 ]
YieldReaction ConditionsOperation in experiment
93.5% With triethylamine; In dichloromethane; at 20℃; for 24h; Roundbottom flask is charged with 5-bromo-2-methylaniline( 400.00 mg; 2.15 mmol; 1 .0 eg.), triethylamine ( 330.76 mL; 2.36 mmol; 1.1 eq.) and anhydrous dichloromethane (12 mL). Acetyl chloride ( 185.64 mg; 2.36 mmol; 1.1 eq.) is then added dropwise and reaction mixture is stirred at room temperature for 24h. After this time diethyl ether (24 mL) is added and mixture is washed with saturated aqueous solution of ammonium chloride (2x20 mL) and brine (2x20 mL). Organic layer is then dried over anhydrous Na2SO4 overnight. The second organic solvent is evaporated to afford N-(5- bromo-2-methylphenyl)acetamide (513.20 mg; yield 93.5 %; 89.3 % by UPLC) as brown solid.
  • 2
  • [ 621-38-5 ]
  • [ 112359-25-8 ]
  • [ 116436-10-3 ]
 

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