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Chemical Structure| 621-38-5 Chemical Structure| 621-38-5

Structure of 621-38-5

Chemical Structure| 621-38-5

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Product Details of [ 621-38-5 ]

CAS No. :621-38-5
Formula : C8H8BrNO
M.W : 214.06
SMILES Code : CC(NC1=CC=CC(Br)=C1)=O
MDL No. :MFCD00461391
InChI Key :XXHOHJTVFUJJMT-UHFFFAOYSA-N
Pubchem ID :12123

Safety of [ 621-38-5 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of [ 621-38-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 621-38-5 ]

[ 621-38-5 ] Synthesis Path-Downstream   1~41

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  • [ 621-38-5 ]
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  • [ 58202-88-3 ]
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  • [ 40787-96-0 ]
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  • [ 621-38-5 ]
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  • [ 40787-96-0 ]
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  • [ 621-38-5 ]
  • acetic acid-(3-bromo-2,4-dichloro-anilide) [ No CAS ]
  • acetic acid-(5-bromo-2,4-dichloro-anilide) [ No CAS ]
  • 12
  • [ 621-38-5 ]
  • acetic acid-(5-bromo-2,4-dichloro-anilide) [ No CAS ]
  • 13
  • [ 621-38-5 ]
  • [ 3460-28-4 ]
  • 14
  • [ 108-24-7 ]
  • [ 591-19-5 ]
  • [ 621-38-5 ]
YieldReaction ConditionsOperation in experiment
100% With dmap; triethylamine; In dichloromethane; at 10 - 20℃; for 4h; 691 mL of acetic anhydride are added to a solution cooled to 10C of 1200 g (6.976 mol, 1 eq) of 3-bromoaniline in 6 L of dichloromethane in the presence of 1.07 L (7.67 mol, 1.1 eq) of triethylamine and 25.6 g (0.209 mol, 0.03 eq) of 4-(dimethylamino)pyridine. The reaction medium is stirred at room temperature for 4 hours and then hydrolysed with 850 mL of 1N hydrochloric acid solution, and the phases are separated by settling. The organic phase is washed with 0.5N hydrochloric acid solution and then with water, and the solvent is evaporated off. After recrystallization from diisopropyl ether/heptane, 1506.1 g of N-(3-bromophenyl)acetamide are obtained in solid form. Yield = 100%
95% With Ni2B-Cu2O nanocomposite; In neat (no solvent); at 40℃; for 0.0333333h; General procedure: For example, a mixture of aniline (1 mmol), Ni2B-Cu2O (54 mg), and acetic anhydride (1 mmol) was ground using a simple porcelain mortar and pestle for a minute at 40 C (in an oil bath). Reaction progress was monitored by TLC with nhexane:EtOAc:MeOH (5:3:1) as eluent. After reaction completion, the reaction mixture was cooled to room temperature, then 5 mL distilled water was added to the reaction vessel; subsequently, the reaction mixture was transferred to a flask (25 mL) equipped with a magnetic stirrer. The mentioned mixture was stirred vigorously for 2 min. Next, the product was extracted with dichloromethane (5 9 3 mL). Extraction solution was dried with anhydrous sodium sulfate then passed through a cotton filter. Evaporation of the solvent afforded pure acetanilide in 98 % yield.
88.58% In dichloromethane; at 10 - 20℃; for 3h; 50 g of m-bromoaniline (290 mmol) was added to a 500 ml three-necked flask.Add 200ml of dichloromethane to 10-15 C,30.5 g of acetic anhydride (299 mmol) was added dropwise.The mixture was incubated at room temperature for 3 h.After the TLC test, the reaction of the raw materials is completed, and 30 g of water is added dropwise at room temperature.Incubate at room temperature for 0.5 h, add 10% sodium hydroxide solution to adjust pH=8-9,Incubate for 10 min, retest pH = 8-9, separate the organic phase, and dehydrate the solvent at 30-40 C.Recrystallized from ethanol: water = 2:5.55.1 g of compound A was obtained, and the yield was 88.58%.The purity is 99.15%.
at 80℃; for 3h; Production Example 2N-{3-[2-(4- hydrazinocarbonylmethylphenyl ) ethyl ] phenyl } acetamide hydrochlorideUsing N- (3-bromophenyl) acetamide obtained by heating 3- bromophenylamine in acetic anhydride at 80C for 3 hrs as a starting material, the title compound was synthesized by a method similar to Production Example 1, steps 4 - 6.
With triethylamine; In dichloromethane; at 20℃; Triethylamine (1.2 equiv) and acetic anhydride (1.5 equiv) inCH2Cl2 were added to a solution of 3-bromoaniline (1 equiv). Thereaction mixture was stirred at rt. Upon completion, the mixturewas diluted with water and extracted with CH2Cl2. The organicphases were combined, washed with saline, dried over anhydrousNa2SO4 and evaporated to afford crude product 13. Pd(dppf)Cl2(0.05 equiv) was added to a solution of compound 13 (1 equiv),bis(pinacolato)diboron (1.2 equiv), and AcOK (3 equiv) in dioxane.The mixture was degassed with nitrogen and heated at 80 Covernight. The mixture was diluted with ethyl acetate, and theorganic layerwaswashed with saline, dried over anhydrous Na2SO4and filtered. The filtrate was concentrated and purified usingchromatography to provide the coupling intermediate 14. MS (ESI)m/z(%): 262.1 [MH].

  • 15
  • [ 621-38-5 ]
  • [ 79-04-9 ]
  • acetic acid-(3-bromo-4-chloroacetyl-anilide) [ No CAS ]
  • 16
  • [ 108-86-1 ]
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  • [ 54446-36-5 ]
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  • [ 5177-66-2 ]
  • [ 89415-50-9 ]
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  • [ 398151-69-4 ]
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  • [ 621-38-5 ]
  • [ 88288-11-3 ]
  • [ 88288-12-4 ]
  • 20
  • [ 91731-85-0 ]
  • [ 621-38-5 ]
  • 3-Bromo-benzenediazonium; hydrogen sulfate [ No CAS ]
  • 21
  • [ 768-90-1 ]
  • [ 621-38-5 ]
  • [ 59974-52-6 ]
  • 22
  • [ 621-38-5 ]
  • [ 479-33-4 ]
  • [ 37038-71-4 ]
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  • [ 479-33-4 ]
  • [ 37038-69-0 ]
  • 24
  • [ 38521-46-9 ]
  • [ 621-38-5 ]
  • 2-(3-acetaminophenylthio)nicotinic acid [ No CAS ]
  • 25
  • [ 585-79-5 ]
  • [ 108-24-7 ]
  • [ 621-38-5 ]
  • N-Acetoxy-N-(3-bromo-phenyl)-acetamide [ No CAS ]
  • 26
  • [ 621-38-5 ]
  • [ 153624-64-7 ]
YieldReaction ConditionsOperation in experiment
6.9 g (82%) With chlorosulfonic acid; In (2S)-N-methyl-1-phenylpropan-2-amine hydrate; ethyl acetate; A. 2-Bromo-4-(1-oxoethylamino)-benzenesulfonyl chloride To 2-bromo-4-(1-oxoethylamino)-benzene (6.2 g, 29 mmol) was added chlorosulfonic acid (20 mL). The solution was heated at 57 C. for 3 hours, an additional 10 mL of chlorosulfonic acid was added and the solution was heated at 67 C. for 6 hours. The mixture was added dropwise to ice water and the heterogeneous mixture was extracted with ethyl acetate. The organic extract was washed once with brine, dried (magnesium sulfate) and evaporated. The residue was dissolved in ethyl acetate (50 mL) and the solution was filtered. The insoluble solid was rinsed twice with ethyl acetate and the combined filtrates were evaporated to afford 6.9 g (82%) of crude compound A as a brown foamy gum.
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  • [ 58207-97-9 ]
  • [ 261177-34-8 ]
  • 28
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  • [ 128838-90-4 ]
  • 3-[4,4'-diethoxybut-1'-enyl]acetanilide [ No CAS ]
  • 3-[4,4'-diethoxybut-1'-enyl]acetanilide [ No CAS ]
  • 29
  • [ 621-38-5 ]
  • [ 124582-25-8 ]
  • [ 261177-30-4 ]
  • 30
  • [ 621-38-5 ]
  • Tributyl-((E)-non-1-enyl)-stannane [ No CAS ]
  • [ 261177-31-5 ]
  • 33
  • [ 7664-93-9 ]
  • [ 621-38-5 ]
  • [ 64-19-7 ]
  • potassium nitrate [ No CAS ]
  • [ 5228-61-5 ]
  • [ 40787-96-0 ]
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  • [ 585-79-5 ]
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  • [ 917-92-0 ]
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  • [ 745830-12-0 ]
  • 36
  • [ 621-38-5 ]
  • [ 68-12-2 ]
  • [ 136812-31-2 ]
YieldReaction ConditionsOperation in experiment
To DMF (16 mL) was added POCl3 (48.8 mL, 523 mmol) dropwise via cannula over 30 minutes at 0 C, and the reaction mixture was stirred for another 30 minutes at this temperature. <strong>[621-38-5]N-(3-bromophenyl)acetamide</strong> (16 g, 75 mmol) was added to the mixture and the reaction was stirred at 80 C for 2 h. The mixture was concentrated under reduced pressure. The residue was diluted with saturated aqueous NaHCO3 (200 mL) and extracted with EtOAc (1000 mL). The organic phase was washed with water (600 mL) and brine (300 mL), and dried over anhydrous sodium sulfate, filtered, and the filtrate was concentrated under reduced pressure. The residue was purified by column chromatography on silica (20% EtOAc/petroleum ether) to afford 7- bromo-2-chloroquinoline-3-carbaldehyde as a solid. Then, 7-bromo-2-chloroquinoline-3- carbaldehyde (1.8 g, 6.65 mmol) was co-evaporated with toluene (5 mL) three times. To a solution of 7-bromo-2-chloroquinoline-3-carbaldehyde (1.8 g, 6.65 mmol) in DCM (27 mL) was added DAST (1.76 mL, 13.3 mmol) at 0 C, and the mixture was stirred at 50 C for 1.5 h. The reaction was diluted with saturated aqueous NaHCO3 (50 mL) at 0 C and extracted with EtOAc (250 mL). The organic layer was washed with water (100 mL) and brine (100 mL), dried over anhydrous sodium sulfate, filtered, and the filtrate was concentrated under reduced pressure. The residue was purified by column chromatography on silica (30% DCM/petroleum ether) to afford 7-bromo-2-chloro-3-(difluoromethyl)quinoline as a solid. MS: 291, 293 (M + 1).
With trichlorophosphate; at 0 - 80℃; for 2h; Step 1: To DMF (16 mL) was added POCI3 (48.8 mL. 523 mmol) dropwise via cannula over 30 minutes at 0 C. and the reaction mixture was stirred for another 30 minutes at this temperature. Then, N-(3-brornophenyi)acetamide (16 g, 75 minol) was added to the mixture and the reaction was stirred at 80 C for 2 It The solvent was then removed under reduced pressure to afford crude residue which was diluied with 200 mL of saturated aqueous NaHCO3 and extracted with1000 inL of EtOAc. The organic phase was washed with water (600 mL), brine (300 mL), dried over anhydrous sodium sulfate, filtered, and the filtrate was concentrated under reduced pressure. The resulting residue was purified by silica gel column chromatography (eluted with 20% EtOAc/PE) to afford 7-brorno-2.-chloroquinoline-3-carbaldehyde as a solid. Then, 7-bromo-2- cliloroquinoline-3-carbaldehyde (1.8 g, 6.65 mmol) was coevaporated with toluene (5 rnL) threetimes. To a. solution of 7-brorno-2-chloroquinohne-3-carbaldehvde (1.8 g, 6.65 mmol) in DCM(27 ni) was added DAST (1.76 mL, 13.31 mmol) at 0 C, and the nixiure was then stuffed at50 C for 1.5 h. The reaction was diluted with 50 rnL of saturated aqueous Nal-{C03 at 0 C andextracted with 250 rnL EtOAc. The organic phase was washed with water (100 mL), brine (100mL), dried over anhydrous sodium sulfate, filtered, and the filtrate was concentrated underreduced pressure. The resulting residue was purified by silica gel column chromatography(eluted with 30% DCM/PE) to afford 7-brorno-2-chloro-3-(difluorornethyl)quinoline as a solid.MS: 292/294 (M ± 1/M ± 3).
  • 37
  • [ 141-78-6 ]
  • [ 591-19-5 ]
  • [ 621-38-5 ]
  • 38
  • [ 621-38-5 ]
  • [ 156545-07-2 ]
  • <i>N</i>-(3',5'-difluoro-biphenyl-3-yl)-acetamide [ No CAS ]
  • 39
  • [ 621-38-5 ]
  • [ 168267-41-2 ]
  • <i>N</i>-(3',4'-difluoro-biphenyl-3-yl)-acetamide [ No CAS ]
  • 40
  • [ 621-38-5 ]
  • [ 144025-03-6 ]
  • N-(2',4'-difluorobiphenyl-3-yl)acetamide [ No CAS ]
  • 41
  • [ 3638-73-1 ]
  • [ 64-19-7 ]
  • [ 621-38-5 ]
 

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