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Chemical Structure| 1169786-94-0 Chemical Structure| 1169786-94-0

Structure of 1169786-94-0

Chemical Structure| 1169786-94-0

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Product Details of [ 1169786-94-0 ]

CAS No. :1169786-94-0
Formula : C9H7ClN2
M.W : 178.62
SMILES Code : CC1=CC=CC2=CN=C(Cl)N=C12
MDL No. :MFCD15527161

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Application In Synthesis of [ 1169786-94-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1169786-94-0 ]

[ 1169786-94-0 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 3325-11-9 ]
  • [ 1169786-94-0 ]
  • [ 1169786-99-5 ]
YieldReaction ConditionsOperation in experiment
hydrogenchloride; In water; butan-1-ol; at 120℃; for 0.25h;Microwave irradiation; Example 2 Preparation of N-(1H-benzo[d][1,2,3]triazol-5-yl)-8-methylquinazoline-2-amine In accordance with Scheme 1 described above, the compound (I) of the present invention was prepared. Specifically, a mixed solution of 2-chloro-8-methylquinazoline (compound (III)-A) (71 mg, 0.4 mmol) of Reference Example 1, 5-aminobenztriazole (67 mg, 0.5 mmol), a drop of concentrated hydrochloric acid and n-butanol (1.5 mL) was reacted for 15 minutes using a microwave synthesis apparatus (manufactured by CEM Co., 120°C, 100 W). The reaction mixture was diluted with ethyl acetate and washed with water, and then the organic layer was dried over anhydrous magnesium sulfate. The solvent was distilled off under reduced pressure, and then the residue was purified by silica gel chromatography (ethyl acetate:n-hexane = 2:1) to obtain 15 mg of the following compound (I)-B, which is a kind of the compound (I) of the present invention, as a colorless powder. [Show Image] 1H-NMR (DMSO-d6) d (ppm): 2.73 (s, 3H), 7.34 (dd, 1H, J = 7.8, 7.2 Hz), 7.6-7.7 (m, 1H), 7.75 (d, 1H, J = 7.2 Hz), 7.80 (d, 1H, J = 7.8 Hz), 7.8-7.95 (m, 1H), 9.00 (s, 1H), 9.33 (s, 1H), 10.25 (s, 1H); MALDI TOF-MS (m/z): 277 [M+H]+.
 

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