117724-62-6|Ethyl 2-methyl-4-(trifluoromethyl)thiazole-5-carboxylate| Ambeed

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CAS No. :	117724-62-6
Formula :	C₈H₈F₃NO₂S
M.W :	239.22
SMILES Code :	O=C(C1=C(C(F)(F)F)N=C(C)S1)OCC
MDL No. :	MFCD00153150

Yield	Reaction Conditions	Operation in experiment
	With potassium hydroxide;	REFERENCE EXAMPLE 2 Synthesis of 2-methyl-4-trifluoromethylthiazole-5-carboxylic acid 1.3 g of ethyl 2-methyl-4-trifluoromethylthiazole-5-carboxylate and 0.4 g of potassium hydroxide were dissolved in a mixture of 5 ml each of water and ethanol and reaction was effected at room temperature overnight. After the reaction, the reaction mixture was concentrated and acidified with dilute hydrochloric acid and extracted with ethyl acetate. The extract was concentrated to obtain 0.89 g of 2-methyl-4-trifluoromethylthiazole-5-carboxylic acid.
21.5 g	With sodium hydroxide; In ethyl acetate; at 40℃; for 1h;	115 g of ethyl 2-methyl-4- (trifluoromethyl) thiazole-5-carboxylate (0.102 mol)Of ethyl acetate solution,50 g of a 40% sodium hydroxide solution was added dropwise to the reaction vessel at room temperature,Dropping speed was controlled so that the internal temperature of the system was lower than 40 C,After the dropwise addition of the sodium hydroxide solution,Insulation reaction 60min.After heat preservation,Taking the organic phase,To this was slowly added 10% hydrochloric acid,Adjusted to the system PH ? 2,At this point a large number of estimates of precipitation,The product was filtered,The filter cake was washed twice with 10% hydrochloric acid and dried in a vacuum oven.Methyl-4- (trifluoromethyl) thiazole-5-carboxylic acid as a light yellow solid, 21.5 g of 2-methyl-4- (trifluoromethyl) 98.8%, and the reaction yield was 98.70%.

Precautionary Statements-General
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Response
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P321
P322
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P378
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P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
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P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
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P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
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P370 + P378	In case of fire:
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P401
P402	Store in a dry place.
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Disposal
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Physical hazards
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H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
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H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
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H228	Flammable solid
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H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
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H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
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H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
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H314	Causes severe skin burns and eye damage
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H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
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H340	May cause genetic defects
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H351	Suspected of causing cancer
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H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
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H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

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CAS No.: 117724-62-6

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CAS No.: 117724-62-6

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