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Chemical Structure| 1182358-83-3 Chemical Structure| 1182358-83-3

Structure of 1182358-83-3

Chemical Structure| 1182358-83-3

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Product Details of [ 1182358-83-3 ]

CAS No. :1182358-83-3
Formula : C4H7N3O2
M.W : 129.12
SMILES Code : O=C1N(C)C(CO)=NN1
MDL No. :MFCD22393449
InChI Key :JVQISFAXAJZVDE-UHFFFAOYSA-N
Pubchem ID :57927640

Safety of [ 1182358-83-3 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319
Precautionary Statements:P264-P280-P302+P352-P305+P351+P338-P332+P313-P337+P313-P362

Application In Synthesis of [ 1182358-83-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1182358-83-3 ]

[ 1182358-83-3 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 7397-62-8 ]
  • [ 624-83-9 ]
  • [ 1182358-83-3 ]
YieldReaction ConditionsOperation in experiment
74% Hydrazine Hydrate (150g, 3 mol) was added dropwise to <strong>[7397-62-8]butyl hydroxyacetate</strong> (417 g, 3 mol) (exotherm). The mixture was slowly heated to 50 SC for 1H. N-Butanol was azeotroped with water. The crude hydrazide was dissolved in water (750 mL) and cooled to -10. Methyl isocyanate (171 g, 3 mol) was added (very exotherm) and the resulting mixture was stirred at room temperature overnight. The resulting mixture was treated with sodium hydroxide solution (360g, 50 wt% in water, 4.5 mol) (exotherm). The resulting solution was heated to 95 SC overnight. The reaction mixture was neutralized with concentrated hydrochloric acid (555g, 30%, 4.5 mol). The resulting mixture was concentrated to dryness and extracted with DMF (1 L). The DMF was removed under vacuum and the product was crystallized from ethyleneglycol (700 mL) to yield 250g, 74% yield). Mp. 144-145 SC.
 

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