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Chemical Structure| 1187875-93-9 Chemical Structure| 1187875-93-9

Structure of 1187875-93-9

Chemical Structure| 1187875-93-9

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Product Details of [ 1187875-93-9 ]

CAS No. :1187875-93-9
Formula : C9H8ClN3
M.W : 193.63
SMILES Code : ClC1=CC=NC2=CC(C3CC3)=NN12
MDL No. :MFCD28523928

Safety of [ 1187875-93-9 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319
Precautionary Statements:P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330

Application In Synthesis of [ 1187875-93-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1187875-93-9 ]

[ 1187875-93-9 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 904326-92-7 ]
  • [ 1187875-93-9 ]
  • 2-cyclopropyl-7-(6-fluoro-5-methylpyridin-3-yl)pyrazolo[1,5-a]pyrimidine [ No CAS ]
YieldReaction ConditionsOperation in experiment
52 mg With chloro(2-dicyclohexylphosphino-2?,4?,6?-triisopropyl-1,1?-biphenyl)[2-(2?-amino-1,1?-biphenyl?)]palladium(II); caesium carbonate; In 1,4-dioxane; water; at 85℃; for 2.0h;Inert atmosphere; To a stirred solution of 7-chloro-2-cyclopropylpyrazolo [1 ,5-ajpyrimidine(100 mg, 0.5 16 mmol), <strong>[904326-92-7](6-fluoro-5-methylpyridin-3-yl)boronic acid</strong> (80 mg, 0.5 16mmol), and cesium carbonate (337 mg, 1.033 mmol) in a mixture of 1,4-dioxane (5 mL) and water (0.5 mL) was purged with nitrogen. XPhos generation precatalyst (61.0 mg, 0.077 mmol) was added in one portion and the reaction mixture was heated to 85 C and stirred for 2 h. The reaction mixture was allowed to cool to room temperature. Water (50 mL) was added and the solution was extracted with EtOAc (2 x 50 mL). The combined organic extracts were washed with water (50 mL) and brine (50 mL), dried over sodium sulfate, filtered, and concentrated under reducedpressure. The residue was purified by silica gel chromatography (EtOAc in hexanes) to afford 2-cyclopropyl-7-(6-fluoro-5-methylpyridin-3 -yl)pyrazolo[ 1,5 -alpyrimidine (52 mg, 0.08 1 mmol, 16% yield). The product was carried forward without further purification. LCMS (ESI) m/e 269.2 [(M+H), calcd for C15H14FN4, 269.11; LC/MS retention time (method H) tR = 2.31 mm.
 

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