Purity | Size | Price | VIP Price | USA Stock *0-1 Day | Global Stock *5-7 Days | Quantity | |||||
{[ item.p_purity ]} | {[ item.pr_size ]} |
{[ getRatePrice(item.pr_usd, 1,1) ]} {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate) ]} |
{[ getRatePrice(item.pr_usd, 1,1) ]} | Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate) ]} {[ getRatePrice(item.pr_usd,1,item.mem_rate) ]} | {[ item.pr_usastock ]} | Inquiry - | {[ item.pr_chinastock ]} | Inquiry - |
* Storage: {[proInfo.prStorage]}
CAS No. : | 119-52-8 | MDL No. : | MFCD00008411 |
Formula : | C16H16O4 | Boiling Point : | - |
Linear Structure Formula : | - | InChI Key : | LRRQSCPPOIUNGX-UHFFFAOYSA-N |
M.W : | 272.30 | Pubchem ID : | 95415 |
Synonyms : |
|
Num. heavy atoms : | 20 |
Num. arom. heavy atoms : | 12 |
Fraction Csp3 : | 0.19 |
Num. rotatable bonds : | 5 |
Num. H-bond acceptors : | 4.0 |
Num. H-bond donors : | 1.0 |
Molar Refractivity : | 75.27 |
TPSA : | 55.76 Ų |
GI absorption : | High |
BBB permeant : | Yes |
P-gp substrate : | No |
CYP1A2 inhibitor : | Yes |
CYP2C19 inhibitor : | Yes |
CYP2C9 inhibitor : | No |
CYP2D6 inhibitor : | No |
CYP3A4 inhibitor : | Yes |
Log Kp (skin permeation) : | -6.49 cm/s |
Log Po/w (iLOGP) : | 2.39 |
Log Po/w (XLOGP3) : | 2.07 |
Log Po/w (WLOGP) : | 2.3 |
Log Po/w (MLOGP) : | 1.64 |
Log Po/w (SILICOS-IT) : | 3.03 |
Consensus Log Po/w : | 2.29 |
Lipinski : | 0.0 |
Ghose : | None |
Veber : | 0.0 |
Egan : | 0.0 |
Muegge : | 0.0 |
Bioavailability Score : | 0.55 |
Log S (ESOL) : | -2.95 |
Solubility : | 0.308 mg/ml ; 0.00113 mol/l |
Class : | Soluble |
Log S (Ali) : | -2.87 |
Solubility : | 0.367 mg/ml ; 0.00135 mol/l |
Class : | Soluble |
Log S (SILICOS-IT) : | -4.59 |
Solubility : | 0.00697 mg/ml ; 0.0000256 mol/l |
Class : | Moderately soluble |
PAINS : | 0.0 alert |
Brenk : | 0.0 alert |
Leadlikeness : | 0.0 |
Synthetic accessibility : | 2.32 |
Signal Word: | Warning | Class: | N/A |
Precautionary Statements: | P261-P280-P305+P351+P338 | UN#: | N/A |
Hazard Statements: | H302+H312+H332-H315-H319-H335 | Packing Group: | N/A |
GHS Pictogram: |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
80% | With calcium hydride; diphenyldisulfane In 1-methyl-pyrrolidin-2-one for 1.5 h; Reflux | 1 mmol of 2-hydroxy-1,2-bis (4-methoxyphenyl) ethanone, dissolved in 0.8 mlIn N-methylpyrrolidone,At room temperature, 1.2 mmol of diphenyl disulfide,3.2 mmol of calcium hydride and 1.2 mL of N-methylpyrrolidone,After 1.5h reflux,Ether extraction, washed with dilute sodium hydroxide solution several times, the combined aqueous phase was acidified, extracted with ethyl acetate, dried, dried, and further purified by column chromatography,1,2-bis (4-hydroxyphenyl) ethane-1,2-dione in 80percent yield; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
75.3% | General procedure: A solution of the substituted benzoin 1a-d (23 mmol) in 30 mL of formamide was heated to reflux for 3 h. The reaction mixture was poured into 100 mL of water and stirred vigorously to dissolve the gummy product. The resulting powder was filtered, washed with water, and suspended in 5% HCl (200 mL). The solution was heated to 80-90 C and filtered hot. The acidic filtrate was treated with an excess of NH4OH to form a white precipitate, which was filtered and washed with water and cold acetonitrile. | |
70% | at 210 - 220℃; | (1) p-Dimethoxybenzoin (5.0g) is dissolved in formamide (30mL), refluxed at 210 220 for 2 3h, cooled, the temperature of the reaction solution is lowered below 100 , and 100mL of pure water is slowly added. After stirring, the precipitated solid was filtered, washed with a small amount of ether (5 mL × 3), and dried to obtain 4,5-bis (4?-methoxyphenyl) imidazole as a white solid with a yield of 70%. |
67% | for 3.0h;Reflux; | General procedure: A mixture of compound 8a (4.8 g, 0.023 mol) and formamide(30 mL) was heated to reflux for 3 h. The reaction mixture waspoured onto water and stirred vigorously to dissolve the gummyproduct. The resulting solid was filtered, washed with water andsuspended in 5% HCl (200 mL). The solution was heated to 80-90 C and filtered while hot. The filtrate was treated with excessNH4OH where a white precipitate which was formed, filtered andwashed with water to afford compound 16a as white solid (80%),m.p. 230-234 C. |
at 210℃; for 3.0h; | General procedure: A solution of substituted benzoin 1a-3a (23 mmol) in 30 mL of formamide was heated at reflux for 3 h. The reaction mixture was poured into 100 mL of water and stirred vigorously to dissolve the gummy product. The resulting powder was filtered, washed with diethyl ether, then dried in vacuo until constant weight. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
96% | With zinc(II) tetrahydroborate; zirconium(IV) chloride; In tetrahydrofuran; at 20℃; for 1.0h; | General procedure: In a round-bottomed flask (10 mL)equipped with a magnetic stirrer bar, a solution ofbenzil (0.21 g, l mmol) was prepared in THF (3 mL).To this solution, ZrCl4 (0.4 mmol, 0.93 g) andZn(BH4)2 (0.19 g, 2mmol) was added. The resultingmixture was stirred at room temperature for 40 min.The reaction was monitored by TLC (eluent:CCl4/Et2O:5/2). After completion of the reaction, distilledwater (6 mL) was added to the reaction mixtureand stirred for 5 min. The mixture was extractedwith CH2Cl2 (3×10 mL) and dried over anhydrous Na2SO4. Evaporation of the solvent afforded crystalsof 1,2-diphenyl ethane-1,2-diol (0.19 g, 92% yield). |
94% | With aluminum oxide; zinc(II) tetrahydroborate; In tetrahydrofuran; at 20℃; for 0.33h; | General procedure: In a round-bottomed flask (10 mL) equipped with a magnetic stirrer, a solution of benzil(0.21 g, 1 mmol) in THF (3 mL was prepared. To this solution, Zn(BH4)2 (0.190 g, 2 mmol)and then neutral Al2O3 (0.101 g, 1 mmol) were added. The resulting mixture was stirred atroom temperature for 20 min. The progress of the reaction was monitored by TLC (eluent,CCl4/Et2O: 5/2). After completion of the reaction, distilled water (1 mL) was added to thereaction mixture and stirring was continued for an additional 5 min. The mixture was extractedwith CH2Cl2 (3×10 mL) and dried over anhydrous sodium sulfate. Evaporation of thesolvent and short column chromatography of the resulting crude material over abovementioned silica gel afforded pure crystals of 1,2-diphenylethane-1,2-diol (0.20 g, 95 % yield,Table V, entry 1). |
94% | With Zn(2+)*2BH4(1-)*C6H7NO; In acetonitrile; at 20℃; for 0.13333299999999998h; | General procedure: A Typical ProcedureIn a round-bottomed flask (10 mL),equipped with a magnetic stirrer, a solution ofbanzaldehye (0.106 g, l mmol) in CH3CN (3 mL)was prepared. The complex reducing agent (0.1 g,0.5 mmol) was then added and the mixture wasstirred at room temperature. TLC monitored theprogress of the reaction (eluent; Hexane/EtOAc: 9/1). After completion of the reaction within 1 min, asolution of 5% HCl (5 mL) was added to the reactionmixture and stirred for 5 min. The mixture was extracted with CH2Cl2 (3 × 10 mL) and dried overthe anhydrous sodium sulfate. Evaporation of thesolvent and short column chromatography of theresulting crude material over silica gel (0.015-0.040mm) by eluent of (Hexane/EtOAc: 9/1) afforded thepure liquid benzyl alcohol (0.105 g, 98% yield) |
92% | With 2BH4(1-)*Zn(2+)*Cl2Na2; In acetonitrile; at 20℃; for 0.13333299999999998h; | General procedure: In a round-bottomed flask (10 mL), equipped with a magneticstirrer bar, a solution of acetophenone (0.121 g, l mmol) was prepared in CH3CN(3 mL). To this solution, Zn(BH4)2/2NaCl (0.210 g,1 mmol) was added. The resulting mixture was stirred at room temperature for 60 min. The reaction was monitored by TLC(eluent; Hexane/EtOAc: 10/1). After completion of the reaction, distilled water (5 mL) was added to the reaction mixture and stirred for 5 min. The mixture was extracted with CH2Cl2 (3 ×8 mL) and dried over anhydrous Na2SO4. Evaporation of the solvent followed column chromatography of the resulting crude material over silica gel (eluent; Hexane/EtOAc: 10/1) afforded crystals of 1-phenylethanol (0.l1 g, 93 % yield,Table 2, entry 11). |
86% | With Poly(n-butyl-4-vinylpyridinium)borohydride; In ethanol; at 20℃; for 3.7166699999999997h; | General procedure: To a solution of the substrate (1 mmol) in ethanol as asolvent (5 mL) in a round-bottomed flask (25 mL) equippedwith a magnetic stirrer, P(BVP)BH4 (100 mg) was addedand stirred at room temperature. The progress of thereaction was monitored by TLC. On completion of thereaction, the mixture was filtered and the used reagent waswashed successively with HCl (1.0 M, 2 10 mL) andethanol (2 5 mL). The combined filtrates were evaporatedand the pure product was obtained in moderate to excellent yields. In a few cases in which the reaction wasnot complete, the crude product was purified on silica gelwith an appropriate eluent (Scheme 1). |
With hydrogenchloride; sodium borohydrid; In (2S)-N-methyl-1-phenylpropan-2-amine hydrate; ethanol; | SYNTHESIS EXAMPLE 5 [Synthesis of 1,1-bis(p-methoxyphenyl)acetaldehyde (Compound (e))] In 3 liters of dry ethanol, 75 g of <strong>[119-52-8]4,4'-bismethoxybenzoin</strong> and 21 g of sodium borohydride were refluxed for 2 hours. After adding 250 ml of concentrated hydrochloric acid to the reaction mixture, the resulting mixture was poured into 1300 ml of ice water, followed by filtration of deposited crystals. After recrystallized from 95% ethanol, there was obtained 57 g of 1,2-di(p-methoxyphenyl)ethane-1,2-diol, which was then added to 570 ml of 80% acetic acid and stirred at 90 C. for 50 minutes. | |
With sodium tetrahydroborate; In ethanol; at 20℃; for 0.25h; | General procedure: Sodium borohydride (0.03g, 1mmol) was added to benzoin(0.21g, 1mmol) in dry ethanol (10 mL) taken in around-bottomed flask fitted with a guard tube. The resultingreaction mixture was stirred at room temperature for 15 minutes.The progress of the reaction was monitored by TLC.After completion of the reaction, the solid was collected byfiltration and recrystallized from suitable solvent to obtainpure product. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
95% | With air; magnetic magnetite nanoparticles; In ethanol; at 80℃; for 9.0h;Sealed tube; Green chemistry; | General procedure: A mixture of alpha-hydroxy ketone (0.2 mmol), Fe3O4·MNPs (30 mol%)and ethanol (1.5 mL) were placed in a sealed tube. The reaction mixturewas heated at 80 C. After completion of reactions, monitored by thinlayer chromatography, the catalyst was separated magnetically. Thereaction solution was concentrated under reduced pressure and thecrude material was purified by preparative thin-layer chromatographywith petroleum ether-EtOAc as eluent. |
92% | With tert.-butylhydroperoxide; In dodecane; acetonitrile; at 65℃; for 1.0h; | General procedure: A 25 mL round bottom flask was charged with alcohol (1.0 mmol), catalyst (0.02 equiv.), MeCN (5 mL), TBHP (1.5 M solution in dodecane; 1.5 equiv.) and then stirred at 65 C for 1 h. According to Table 2, all reactions require 1 h. At the end of the reaction, the catalyst was filtered at room temperature over membrane filter paper and reused for subsequent runs. The filtrate so obtained was concentrated under reduced pressure and the residue was dissolved in dichloromethane (20 mL). The organic layer was washed with brine solution (10 mL 3×). The organic layer was dried over anhydrous MgSO4 and then, concentrated under reduced pressure. Product was purified by column chromatography over silica gel. The isolated yield of the obtained product was found to be 94% and the conversion was determined by the GC-MS analysis. The purity of the products was determined by comparing the 1H NMR spectra of the products with those of authentic samples. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
94% | With ammonium chloride; zinc In tetrahydrofuran at 20℃; for 1h; | |
92% | With water; zinc trifluoromethanesulfonate; zinc In 1,4-dioxane at 90℃; for 4h; Inert atmosphere; Schlenk technique; Green chemistry; | |
88% | With titanium(IV) iodide In acetonitrile at 0 - 20℃; for 5.3h; |
81% | With sodium hydrogen selenide; acetic acid In tetrahydrofuran; ethanol for 1.5h; Ambient temperature; | |
56% | With acetic acid; zinc at 20℃; Inert atmosphere; | |
With sodium hydroxide; aluminum nickel; toluene | ||
With zinc In water; N,N-dimethyl-formamide | ||
With 3,5,5-trimethyl-2-morpholinon-3-yl In chloroform-d1 at 50℃; | ||
With sodium dithionite; sodium carbonate In diethyl ether; water at 20℃; for 120h; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
89% | With diethylamine In N,N-dimethyl-formamide for 18h; Ambient temperature; | |
40% | With diethylamine In N,N-dimethyl-formamide at 0 - 20℃; for 16.5h; Inert atmosphere; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
45% | With oxygen; sodium hydride; In tetrahydrofuran; mineral oil; at 25℃; under 760.051 Torr; for 2.0h; | General procedure: To a solution of benzoins 1 (0.5 mmol) in distilled THF (5 mL) was added NaH (60% dispersion in mineral oil, 1.0 mmol) at 0 C. While stirring, the dark-blue solution was allowed to warm to room temperature. After stirring under O2 (1 atm), until TLC analysis indicated complete consumption of the starting material, the reaction mixture was quenched by adding 0.1 N HCl to a final pH of 1-2 and extracted with CH2Cl2. The combined organic layers were dried over MgSO4 and concentrated in vacuo. The residue was purified by flash column chromatography to give 2. |
61%Chromat. | With graphitic carbon nitride; oxygen; acetic acid; In water; acetonitrile; at 100℃; under 2250.23 Torr; for 16.0h;Autoclave; Irradiation; Green chemistry; | General procedure: In a typical procedure, mpg-C3N4 (60 mg) and 2-hydroxy-1,2-diphenylethanone (1a, 1.0 mmol) were added to CH3CN (10 mL) in a 100 mL stainless steel autoclave. The O2 (3 bar) source was introduced and the closed autoclave was heated to 100 C, followed by visible light irradiation for 16 h. The reaction mixture turned clear and the catalysts were deposited on the button, which was recovered by filtration. And then the solvent was removed, and the residue was separated by column chromatography to give the pure sample 2a. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
1: 42% 2: 40% | With potassium phosphate buffer; thiamine diphosphate; magnesium sulfate In dimethyl sulfoxide at 20℃; Enzymatic reaction; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
80% | With calcium hydride; diphenyldisulfane; In 1-methyl-pyrrolidin-2-one; for 1.5h;Reflux; | 1 mmol of 2-hydroxy-1,2-bis (4-methoxyphenyl) ethanone, dissolved in 0.8 mlIn N-methylpyrrolidone,At room temperature, 1.2 mmol of diphenyl disulfide,3.2 mmol of calcium hydride and 1.2 mL of N-methylpyrrolidone,After 1.5h reflux,Ether extraction, washed with dilute sodium hydroxide solution several times, the combined aqueous phase was acidified, extracted with ethyl acetate, dried, dried, and further purified by column chromatography,1,2-bis (4-hydroxyphenyl) ethane-1,2-dione in 80% yield; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 2 steps 1: SOCl2; DMF / CH2Cl2 / 5 h 2: ethanol / 18 h / Heating | ||
Multi-step reaction with 2 steps 1: SOCl2 2: ethanol / 6 h / Heating | ||
Multi-step reaction with 2 steps 1: thionyl chloride / dichloromethane; N,N-dimethyl-formamide / 1 h / 0 °C / Inert atmosphere 2: ethanol / 15 h / 80 °C |
Multi-step reaction with 2 steps 1: pyridine; thionyl chloride / 2 h / 20 °C / Cooling 2: ethanol / 2 h / Reflux |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
67% | In ethylene glycol at 180℃; for 2h; | A mixture of 2-hydroxy-l , 2-bis (4-methoxyphenyl) ethanone (1 g, 3.6 mmol) and 1 ,3- dimethylurea (1.29 g, 14.7 mmol) in ethylene glycol (10 mL) was refluxed at 180 °C for 2 h. The reaction mixture was diluted with water and extracted with EtOAc (2 x 50 mL). The combined organic layers were washed with water, dried over Na2SO4, filtered and then concentrated in vacuo. The crude material was purified via silica gel column chromatography eluting with 80% EtOAc in hexanes to afford 4,5-bis(4-methoxyphenyl)- l,3-dimethyl-lH-imidazol-2(3H)-one (0.8 g, 67%) as a solid. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
93% | With pyridine at 150℃; for 22h; | 25 A mixture of p-anisoin (35.3 g, 0.130 mol), methyl carbamate (24.5 g, 0.327 mol), and pyridine (10 ml) was stirred at 150°C for 22 hours and then cooled to room temperature. Distilled water (100 ml) was added to the reaction mixture, and a solid was filtered, followed by rinsing with water. The resulting slurry was washed with ethanol, and a title compound (35.9 g, 0.121 mol, 93%) was obtained as a light brown solid. 1H-NMR (400 MHz, DMSO-d6) δ: 3.76 (3H, s), 3.79 (3H, s), 6.94 (2H, d, J = 8.8 Hz), 7.01 (2H, d, J = 8.8 Hz), 7.31 (2H, d, J = 8.8 Hz), 7.38 (2H, d, J = 8.8 Hz), 11.14 (1H, brs). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With benzaldehyde lyase; thiamine diphosphate; magnesium sulfate In dichloromethane at 30℃; for 96h; Enzymatic reaction; enantioselective reaction; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
1: 78% 2: 15% | With samarium; potassium iodide; copper(l) chloride In tetrahydrofuran at 20℃; for 3h; Inert atmosphere; | Typical Procedure for the Self-Condensation of Aromatic Aldehydes General procedure: Benzaldehyde (0.4 mL, 4 mmol) was added to a mixture of Sm powder (0.3 g, 2 mmol), CuCl (0.2 g, 2 mmol), and KI (0.33 g, 2 mmol) in anhydrous tetrahydrofuran (THF, 10 mL) at room temperature under a nitrogen atmosphere with magnetic stirring. After completion of the reaction (about 2 h, monitored by TLC), dilute hydrochloric acid (2 M, 5 mL) was added and the resulting mixture was extracted with ethyl acetate (320 mL). The combined organic layer was washed with brine and saturated sodium thiosulfate solution, dried over anhydrous sodium sulfate, and concentrated under reduced pressure. The crude product were purified with flash chromatography (silica/hexane-ethyl acetate 5:1 v/v) to afford 0.36 g of the corresponding benzoin (2a) with 84% yield. |
1: 52% 2: 9% | With 1,8-diazabicyclo[5.4.0]undec-7-ene In dimethyl sulfoxide at 25℃; for 40h; Inert atmosphere; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
98% | With 1,3-disulfonic acid imidazolium hydrogen sulfate; In neat (no solvent); at 20℃; for 0.05h;Green chemistry; | General procedure: Ionic liquid [Dsim]HSO4 (6.5 mg, ?0.02 mmol) was added to a stirred mixture of alcohol, phenol or naphthol (1.0 mmol) and HMDS (80 mg, 0.5 mmol) at room temperature under solvent free conditions. After completion of the reaction (monitored by TLC, It should be noted that when addition of HMDS is finished stirring of the mixture is stopped after 1 min. TLC showed that in most of the cases the reaction is completed immediately after the addition of HMDS), the product was extracted with Et2O and the ionic liquid was recovered and was dried at 65 ?C under vacuum to remove moisture, and then reused. Evaporation of the solvent under reduced pressure gave the highly pure product without further purification. The desired pure products were characterized by comparison of their IR, NMR and MS data as well as boiling poin twith those of known compounds |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
94% | With ammonium acetate; In ethanol; water; for 4.0h;Reflux; | General procedure: To a mixture of benzoin derivative (2 mmol) and 1,3-dicarbonyl compound (2 mmol) in H2O-EtOH (2 mL, 50:50)was added NH4OAc (4 mmol), and the mixture was stirred under reflux for the requisite time. After completion of the reaction (TLC), ice was added, and the product was isolated by filtration. |
87% | With C31H68N2O(2+)*2Cl4Fe(1-); ammonium acetate; In neat (no solvent); at 80℃; for 1.0h; | General procedure: For improved synthesis of pyrroles, MGSFe (10mol%) was added to amixture of the corresponding 1,3-dicarbonyl (5mmol), ammonium acetate(6 mmol), and benzoin derivatives (5 mmol) and the mixture was stirred under the solvent-free conditions at 80 C. After the completion of this step (detected by TLC monitoring), the catalyst and product were isolated by two different procedures. In the first work-up, cold water(5 mL) was added, aqueous phase of surfactant-based MGSFe was keptby magnet, the precipitated pyrrole product was isolated, and the MGSFe catalyst was recovered in 99.9% yield after the vacuum evaporation of water from the aqueous phase and reused. In the second alternative work-up, ethyl acetate (50mL) was added to dissolve the pyrrole product, the viscous catalyst was isolated bymagnet, and the product was obtained in pure form by evaporation of the EtOAc from the organic phase. |
86% | With ammonium acetate; In neat (no solvent); at 90℃; for 2.0h;Green chemistry; | General procedure: 1,3-dicarbonyl 1 (1.1mmol), benzoin derivative/ phenyl glyoxal 2(1.0 mmol) and ammonium acetate 3(1.5 mmol) were charged into a 10 mL round-bottom flask, fitted to condenser andthe mixture was heated to 90 C/50 C usingconventional oil bath. The reaction mixture was stirred to 120 min until thestarting material 2 wasconsumed to maximum extent. The reaction mixture was then cooled andrecrystallized with ethanol water 80:20 mixture to obtain pure product 4.(The reaction mixture was dissolved in ethyl acetate (2 ml) and washed withwater (2×2 ml) and the organic layer was separated and adsorbed to silica gel(60-120 mesh size) and column chromatographed using ethyl acetate and petroleumether (80:20) as eluents to obtain pure polyfunctionalized indoles 4m and 4n). |
83% | With ammonium acetate; In ethanol; water; at 55 - 65℃; for 1.5h; | General procedure: General Procedure for Tandem Benzoin Condensation and pMCR Synthesis of Tetrasubstituted Pyrroles: After completion of the reaction of aldehyde (5 mmol), sodium cyanide (20mol%), and CAPB (0.3 mol%) in H2O-EtOH (80:20; TLC monitoring), the requisite 1,3-dicarbonyl compound (5 mmol) andammonium acetate (6 mmol) were added to the stirred reaction mixture at 55-65 C. After completion of the second step, cold H2O (40 mL) was added and the pyrrole product was isolated by filtration without need for further purification.Spectroscopic data of representative compounds follows. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
84 % ee | With D-glucose; allyl alcohol In n-heptane; water; ethyl acetate at 30℃; for 3h; Enzymatic reaction; Overall yield = 76 %; enantioselective reaction; | (R)-2-Hydroxy-1,2-bis(4-methoxyphenyl)ethanone 2e General procedure: A mixture of dry baker’s yeast (2g), water (38mL), glucose (2g) and allyl alcohol (0.1mL) was stirred at 50°C for 30min. After the mixture was cooled to 30°C, the substrate (0.05mmol) dissolved in 0.5mL of organic solvent was added and the reaction was continued to stir at 30°C for 3h. The work-up procedure was essentially the same as that described in the foregoing experiment. Mp 103.2-104.4°C, [α]25D=-75[α]D25=-75 (c 0.25, CH3OH) {lit.34 [α]20D=+88.6[α]D20=+88.6 (c 1, CH3OH) for 98% ee, (S)-enantiomer}, ee=84%. HPLC analysis: Chiralcel OD chiral column, mobile phase iso-PrOH/ hexane: 10:90, flow rate: 1.0mL/min, wavelength: 210nm; tR (retention time): 21.14min for (S)-isomer, 22.80min for (R)-isomer. IR (neat, cm-1): 3446, 3069, 2930, 1676, 1607, 1515, 1461, 1261, 1176, 1038, 838cm-1. 1H NMR (CDCl3): δ 1.18 (br s, 1H), 3.68 (s, 3H), 3.75 (s, 3H), 5.77 (s, 1H), 6.78 (dd, 4H, J1=6.8Hz, J2=7.8Hz), 7.18 (dd, 2H, J1=7.8Hz, J2=1.9Hz), 7.82 (dd, 2H, J1=1.9Hz, J2=6.8Hz). 13C NMR (CDCl3): δ 54.20, 54.52, 74.22, 112.90, 113.53, 125.32, 127.94, 130.52, 130.78, 158.59, 162.91, 196.36. MS m/z: 41, 51, 64, 77, 92, 109, 135, 152, 169, 183, 207, 227, 256, 270 (M+). |
82 % ee | With water, ethyl acetate extract of Talaromyces flavus In aq. buffer for 96h; Green chemistry; Enzymatic reaction; Overall yield = 54 %; enantioselective reaction; | |
84 % ee | With BF4(1-)*C43H55BrFeN3P2(1+) In isopropyl alcohol at 50℃; for 1.5h; Inert atmosphere; Overall yield = 73 %; enantioselective reaction; |
83 % ee | With 2-(naphthalen-2-yl)-1,2,3,4-tetrahydroisoquinoline; (1S,2S)-N1,N2-bis(dipyrrolidin-1-ylmethylene)-1,2-diphenylethane-1,2-diaminium bis(tetrafluoroborate); sodium tetrakis[(3,5-di-trifluoromethyl)phenyl]borate In chlorobenzene at 0℃; for 24h; Schlenk technique; Inert atmosphere; Irradiation; Overall yield = 93 %; Overall yield = 25.3 mg; enantioselective reaction; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
98% | With [P4-VP]-PdNPs; In N,N-dimethyl-formamide; at 120℃; for 0.00833333h;Reflux; | General procedure: A mixture of benzoin (1 mmol), o-phenylenediamine(1.1 mmol) and [P4-VP]-PdNPs (120 mg) was refluxed in DMF (3 mL). After completion of reaction (monitored byTLC, eluent: n-hexane/EtOAc = 9/1), the catalyst was separated and washed with EtOH (2 × 2 mL). After addition of water the product was precipitated with high purity. The pure quinoxalines were obtained in 81-99% isolated yields. |
61% | With cesium hydroxide; In dimethyl sulfoxide; at 90℃; for 24.0h; | Reaction tubes are sequentially added CsOH (0.0126g, 15mol %), ethylenediamine (0.75mmol, 1 . 5equiv.) and finocchio acyloin (0.136g, 0 . 5mmol,), then adding DMSO (1.0 ml) as the solvent, plus atmospheric air ball, heating to 90oC reaction 24h.TLC monitoring after the reaction is complete, post chromatographic separation and purification of product, separation yield 61% |
In methanol; | General procedure: The cyclic Schiff base ligand L1 (5,6-diphenyl-2,3-dihydropyrazine) was prepared by the 1:1 condensation of ethylenediamine (2 mmol, 0.14 ml) and benzoin (2 mmol, 0.424 g) in methanol following the literature method [42]. It was not isolated and a methanol solution (20 ml) of Cu(ClO4)2*6H2O (2 mmol, 0.740 g)was added to it. A deep red crystalline complex was separated instantly and collected by filtration. The complex was characterized by elemental and spectral analysis and by mass spectrometry.We could not grow suitable single crystals of A for X-raydiffraction. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
67% | With pyridine In chloroform at 20℃; for 0.166667h; | 2.2. General Procedure for the Synthesis of 3a-l General procedure: 4,4'-Dimethoxybenzoin (p-anisoin) (2) (1.0 g, 3.67 mmol) was dissolved in a minimum amount of chloroform. Then, the requested benzoyl chloride derivative (4.41 mmol) was added to the reaction vessel followed by pyridine (3ml, 37.5 mmol). The reaction mixture was stirred at RT for 10 min. The crude product was purified by repetitive extraction with basic water (5 % NaOH) followed by extraction with acidic water (5 % HCl) and finally with water. The organic layer was dried over magnesium sulfate and evaporated un der reduced pressure. The solid residue was recrystallized with ethanol to afford the prospective compound. |
66% | With triethylamine In tetrahydrofuran at 50℃; for 24h; | 1,2-Bis(4-methoxyphenyl)-2-oxoethyl 4-fluorobenzoate(10). A solution of 4,4'-Dimethoxy benzoin (p-anisoin) (2) (2.0 g, 7.3 mmol) and 4-fluoro benzoyl chloride(1.3 ml, 11.0 mmol) was dissolved in THF (20 ml) followed by addition oftriethylamine (4 ml, 28.7 mmol). The reaction mixture was stirred for 24 hr at 50°C then cooled to room temperature, and evaporated under reduced pressure. The crude product was filtered and purified using column chromatography (cyclohexane/ethyl acetate, 8:2) to give 10 as a white powder (1.9 g, 66%); Mp. 118-120°C; 1H NMR (500 Hz, DMSO-d6): δ = 8.15 (dd, J = 8.2, 5.4 Hz, 2H, Ar-H), 8.00 (d, J = 8.6 Hz,2H, Ar-H), 7.50 (d, J =8.7 Hz, 2H, Ar-H), 7.16 (t, J = 10 Hz, 2H, Ar-H), 7.14 (t,J = Hz, 2H, Ar-H), 7.04 (s, 1H, OCH), 6.92 (dd, J =8.9, 5.2 Hz, 2H, Ar-H), 3.99 (s, 3H, OCH3), 3.81 (s ,3H, OCH3) ppm; 13C-NMR (DMSO d6): δ = 191.9 (1C), 170.3 (1C), 166.9 (1C), 163.7(1C), 160.3 (1C), 132.2 (2C), 132.6 (2C), 131.2 (2C), 128.9 (1C), 127.4 (1C), 125.9 (1C), 115.6 (2C), 114.6 (2C), 113.9 (2C), 77.4 (1C), 55.5 (1C), 55.3 (1C) ppm; IR (KBr disc): ν = 3070, 2970, 1712, 1681, 1604, 1512, 1242, 1165 cm-1. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
83% | With cesium hydroxide In dimethyl sulfoxide at 90℃; for 24h; | 11 Example 11: anisoin and 3,4-pyridine-2,3- (4-methoxyphenyl) pyrido [3,4-b] pyrazine Reaction tubes are sequentially added CsOH (0.0126g, 15mol %), 3,4-diaminopyridine (0.75mmol, 1 . 5equiv.) and finocchio acyloin (0.136g, 0 . 5mmol,), then adding DMSO (1.0 ml) as the solvent, plus atmospheric air ball, heating to 90oC reaction 24h.TLC monitoring after the reaction is complete, post chromatographic separation and purification of product, separation yield 83% |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
87.5% | With silica gel-supported chlorosulfonic acid In 2-methyltetrahydrofuran at 150℃; for 2h; | 3 At room temperature, to the reaction vessel in an organic solvent, 2-MeTHF was added the above formula (II) Compound of formula (III) compound and silica-supported chlorosulfonic acid. Wherein, the formula (II) and the formula (III) The molar ratio of the compound of 1: 3, the molar ratio of formula (II) with chlorosulfonic acid compound is 1: 0.15; stir Mix warmed up to 150 ° C, and held for 2 hours.After post-processing, as a yellow crystalline product of the formula (the I), in a yield of 87.5%, Purity 98.1% (HPLC). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
99% | at 130 - 140℃; for 1h; | 4.3.3. 4,6-Dimethoxy-2,3-di(4-methoxyphenyl)indole (8b) A stream of HCl gas was bubbled through a suspension of 3,5-dimethoxyaniline (9.85 g, 64.3 mmol) in anhydrous diethyl ether (80 mL) for 0.5 h. The resulting slurry was filtered and washed with ether (100 mL) to give 3,5-dimethoxyanilinium HCl as a yellow salt (11.50 g, 94%). A mixture of 3,5-dimethoxyaniline (2.14 g, 14.0 mmol), anisoin (1.90 g, 7.01 mmol) and 3,5-dimethoxyanilinium HCl (1.60 g, 8.43 mmol) was heated in silicone oil at 130-140 C for 1 h. After cooling, the mixture was washed with light petroleum (2 x 20 mL), extracted with chloroform (3 x 15 mL) and concentrated to yield the indole 8b as a white powder (2.70 g, 99%), mp 102-103 C (from methanol/chloroform) (Found: C, 62.6; H, 5.0; N, 2.9. C 24 H 23 NO 4 •0.7 CHCl 3 requires C, 62.7; H, 5.0; N, 3.0%). νmax (KBr): 3322, 3026, 1731, 1685, 1634, 1584, 1541, 1459, 1388, 1284, 1202 cm -1 . 1 H NMR (300 MHz, CDCl 3 ): δ 3.68 (3H, s, OMe), 3.78 (3H, s, OMe), 3.83 (3H, s, OMe), 3.84 (3H, s, OMe), 6.21 (1H, d, = 1.9 Hz, H5), 6.49 (1H, d, = 1.9 Hz, H7), 6.81 (2H, d, J = 9.0 Hz, aryl H), 6.85 (2H, d, J = 8.6 Hz, aryl H), 7.20 (2H, d, J = 6.7 Hz, aryl H), 7.31 (2H, d, J = 6.3 Hz, aryl H), 8.06 (1H, bs, NH). 13 C NMR (75 MHz, CDCl 3 ): δ 55.0, 55.1, 55.2, 55.6 (OMe), 86.5 (C5), 92.3 (C7), 112.7, 113.9, 125.6, 132.3 (aryl CH), 113.8, 128.4, 128.9, 129.0, 131.6, 137.1, 155.0, 157.4, 157.7, 158.5 (aryl C). Mass Spectrum (+EI): m/z (%) 374 (9), 373 (45), 355 (58), 329 (100), 314 (40), 178 (20), 86 (40), 84 (64), 69 (31), 58 (63). HRMS (ESI + ): [M+H] + . Found 390.1677. C 24 H 24 NO 4 requires 390.1705. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
98% | With sodium hydroxide In toluene at 120℃; for 3h; Inert atmosphere; Sealed tube; Green chemistry; |
Tags: 119-52-8 synthesis path| 119-52-8 SDS| 119-52-8 COA| 119-52-8 purity| 119-52-8 application| 119-52-8 NMR| 119-52-8 COA| 119-52-8 structure
[ 170377-82-9 ]
(S)-2-Hydroxy-1,2-bis(4-methoxyphenyl)ethanone
Similarity: 1.00
[ 6706-95-2 ]
2-Hydroxy-1,2-bis(3-methoxyphenyl)ethanone
Similarity: 0.98
[ 54996-39-3 ]
1-(3,5-Dimethoxyphenyl)-2-hydroxy-2-phenylethanone
Similarity: 0.96
[ 62762-70-3 ]
1-(3,4-Dimethoxyphenyl)-2-hydroxy-2-phenylethanone
Similarity: 0.94
[ 7467-90-5 ]
2-Hydroxy-1,2-bis(3,4,5-trimethoxyphenyl)ethanone
Similarity: 0.92
Precautionary Statements-General | |
Code | Phrase |
P101 | If medical advice is needed,have product container or label at hand. |
P102 | Keep out of reach of children. |
P103 | Read label before use |
Prevention | |
Code | Phrase |
P201 | Obtain special instructions before use. |
P202 | Do not handle until all safety precautions have been read and understood. |
P210 | Keep away from heat/sparks/open flames/hot surfaces. - No smoking. |
P211 | Do not spray on an open flame or other ignition source. |
P220 | Keep/Store away from clothing/combustible materials. |
P221 | Take any precaution to avoid mixing with combustibles |
P222 | Do not allow contact with air. |
P223 | Keep away from any possible contact with water, because of violent reaction and possible flash fire. |
P230 | Keep wetted |
P231 | Handle under inert gas. |
P232 | Protect from moisture. |
P233 | Keep container tightly closed. |
P234 | Keep only in original container. |
P235 | Keep cool |
P240 | Ground/bond container and receiving equipment. |
P241 | Use explosion-proof electrical/ventilating/lighting/equipment. |
P242 | Use only non-sparking tools. |
P243 | Take precautionary measures against static discharge. |
P244 | Keep reduction valves free from grease and oil. |
P250 | Do not subject to grinding/shock/friction. |
P251 | Pressurized container: Do not pierce or burn, even after use. |
P260 | Do not breathe dust/fume/gas/mist/vapours/spray. |
P261 | Avoid breathing dust/fume/gas/mist/vapours/spray. |
P262 | Do not get in eyes, on skin, or on clothing. |
P263 | Avoid contact during pregnancy/while nursing. |
P264 | Wash hands thoroughly after handling. |
P265 | Wash skin thouroughly after handling. |
P270 | Do not eat, drink or smoke when using this product. |
P271 | Use only outdoors or in a well-ventilated area. |
P272 | Contaminated work clothing should not be allowed out of the workplace. |
P273 | Avoid release to the environment. |
P280 | Wear protective gloves/protective clothing/eye protection/face protection. |
P281 | Use personal protective equipment as required. |
P282 | Wear cold insulating gloves/face shield/eye protection. |
P283 | Wear fire/flame resistant/retardant clothing. |
P284 | Wear respiratory protection. |
P285 | In case of inadequate ventilation wear respiratory protection. |
P231 + P232 | Handle under inert gas. Protect from moisture. |
P235 + P410 | Keep cool. Protect from sunlight. |
Response | |
Code | Phrase |
P301 | IF SWALLOWED: |
P304 | IF INHALED: |
P305 | IF IN EYES: |
P306 | IF ON CLOTHING: |
P307 | IF exposed: |
P308 | IF exposed or concerned: |
P309 | IF exposed or if you feel unwell: |
P310 | Immediately call a POISON CENTER or doctor/physician. |
P311 | Call a POISON CENTER or doctor/physician. |
P312 | Call a POISON CENTER or doctor/physician if you feel unwell. |
P313 | Get medical advice/attention. |
P314 | Get medical advice/attention if you feel unwell. |
P315 | Get immediate medical advice/attention. |
P320 | |
P302 + P352 | IF ON SKIN: wash with plenty of soap and water. |
P321 | |
P322 | |
P330 | Rinse mouth. |
P331 | Do NOT induce vomiting. |
P332 | IF SKIN irritation occurs: |
P333 | If skin irritation or rash occurs: |
P334 | Immerse in cool water/wrap n wet bandages. |
P335 | Brush off loose particles from skin. |
P336 | Thaw frosted parts with lukewarm water. Do not rub affected area. |
P337 | If eye irritation persists: |
P338 | Remove contact lenses, if present and easy to do. Continue rinsing. |
P340 | Remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P341 | If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P342 | If experiencing respiratory symptoms: |
P350 | Gently wash with plenty of soap and water. |
P351 | Rinse cautiously with water for several minutes. |
P352 | Wash with plenty of soap and water. |
P353 | Rinse skin with water/shower. |
P360 | Rinse immediately contaminated clothing and skin with plenty of water before removing clothes. |
P361 | Remove/Take off immediately all contaminated clothing. |
P362 | Take off contaminated clothing and wash before reuse. |
P363 | Wash contaminated clothing before reuse. |
P370 | In case of fire: |
P371 | In case of major fire and large quantities: |
P372 | Explosion risk in case of fire. |
P373 | DO NOT fight fire when fire reaches explosives. |
P374 | Fight fire with normal precautions from a reasonable distance. |
P376 | Stop leak if safe to do so. Oxidising gases (section 2.4) 1 |
P377 | Leaking gas fire: Do not extinguish, unless leak can be stopped safely. |
P378 | |
P380 | Evacuate area. |
P381 | Eliminate all ignition sources if safe to do so. |
P390 | Absorb spillage to prevent material damage. |
P391 | Collect spillage. Hazardous to the aquatic environment |
P301 + P310 | IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. |
P301 + P312 | IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. |
P301 + P330 + P331 | IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. |
P302 + P334 | IF ON SKIN: Immerse in cool water/wrap in wet bandages. |
P302 + P350 | IF ON SKIN: Gently wash with plenty of soap and water. |
P303 + P361 + P353 | IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. |
P304 + P312 | IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell. |
P304 + P340 | IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. |
P304 + P341 | IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P305 + P351 + P338 | IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. |
P306 + P360 | IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes. |
P307 + P311 | IF exposed: call a POISON CENTER or doctor/physician. |
P308 + P313 | IF exposed or concerned: Get medical advice/attention. |
P309 + P311 | IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician. |
P332 + P313 | IF SKIN irritation occurs: Get medical advice/attention. |
P333 + P313 | IF SKIN irritation or rash occurs: Get medical advice/attention. |
P335 + P334 | Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages. |
P337 + P313 | IF eye irritation persists: Get medical advice/attention. |
P342 + P311 | IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician. |
P370 + P376 | In case of fire: Stop leak if safe to Do so. |
P370 + P378 | In case of fire: |
P370 + P380 | In case of fire: Evacuate area. |
P370 + P380 + P375 | In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion. |
P371 + P380 + P375 | In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion. |
Storage | |
Code | Phrase |
P401 | |
P402 | Store in a dry place. |
P403 | Store in a well-ventilated place. |
P404 | Store in a closed container. |
P405 | Store locked up. |
P406 | Store in corrosive resistant/ container with a resistant inner liner. |
P407 | Maintain air gap between stacks/pallets. |
P410 | Protect from sunlight. |
P411 | |
P412 | Do not expose to temperatures exceeding 50 oC/ 122 oF. |
P413 | |
P420 | Store away from other materials. |
P422 | |
P402 + P404 | Store in a dry place. Store in a closed container. |
P403 + P233 | Store in a well-ventilated place. Keep container tightly closed. |
P403 + P235 | Store in a well-ventilated place. Keep cool. |
P410 + P403 | Protect from sunlight. Store in a well-ventilated place. |
P410 + P412 | Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF. |
P411 + P235 | Keep cool. |
Disposal | |
Code | Phrase |
P501 | Dispose of contents/container to ... |
P502 | Refer to manufacturer/supplier for information on recovery/recycling |
Physical hazards | |
Code | Phrase |
H200 | Unstable explosive |
H201 | Explosive; mass explosion hazard |
H202 | Explosive; severe projection hazard |
H203 | Explosive; fire, blast or projection hazard |
H204 | Fire or projection hazard |
H205 | May mass explode in fire |
H220 | Extremely flammable gas |
H221 | Flammable gas |
H222 | Extremely flammable aerosol |
H223 | Flammable aerosol |
H224 | Extremely flammable liquid and vapour |
H225 | Highly flammable liquid and vapour |
H226 | Flammable liquid and vapour |
H227 | Combustible liquid |
H228 | Flammable solid |
H229 | Pressurized container: may burst if heated |
H230 | May react explosively even in the absence of air |
H231 | May react explosively even in the absence of air at elevated pressure and/or temperature |
H240 | Heating may cause an explosion |
H241 | Heating may cause a fire or explosion |
H242 | Heating may cause a fire |
H250 | Catches fire spontaneously if exposed to air |
H251 | Self-heating; may catch fire |
H252 | Self-heating in large quantities; may catch fire |
H260 | In contact with water releases flammable gases which may ignite spontaneously |
H261 | In contact with water releases flammable gas |
H270 | May cause or intensify fire; oxidizer |
H271 | May cause fire or explosion; strong oxidizer |
H272 | May intensify fire; oxidizer |
H280 | Contains gas under pressure; may explode if heated |
H281 | Contains refrigerated gas; may cause cryogenic burns or injury |
H290 | May be corrosive to metals |
Health hazards | |
Code | Phrase |
H300 | Fatal if swallowed |
H301 | Toxic if swallowed |
H302 | Harmful if swallowed |
H303 | May be harmful if swallowed |
H304 | May be fatal if swallowed and enters airways |
H305 | May be harmful if swallowed and enters airways |
H310 | Fatal in contact with skin |
H311 | Toxic in contact with skin |
H312 | Harmful in contact with skin |
H313 | May be harmful in contact with skin |
H314 | Causes severe skin burns and eye damage |
H315 | Causes skin irritation |
H316 | Causes mild skin irritation |
H317 | May cause an allergic skin reaction |
H318 | Causes serious eye damage |
H319 | Causes serious eye irritation |
H320 | Causes eye irritation |
H330 | Fatal if inhaled |
H331 | Toxic if inhaled |
H332 | Harmful if inhaled |
H333 | May be harmful if inhaled |
H334 | May cause allergy or asthma symptoms or breathing difficulties if inhaled |
H335 | May cause respiratory irritation |
H336 | May cause drowsiness or dizziness |
H340 | May cause genetic defects |
H341 | Suspected of causing genetic defects |
H350 | May cause cancer |
H351 | Suspected of causing cancer |
H360 | May damage fertility or the unborn child |
H361 | Suspected of damaging fertility or the unborn child |
H361d | Suspected of damaging the unborn child |
H362 | May cause harm to breast-fed children |
H370 | Causes damage to organs |
H371 | May cause damage to organs |
H372 | Causes damage to organs through prolonged or repeated exposure |
H373 | May cause damage to organs through prolonged or repeated exposure |
Environmental hazards | |
Code | Phrase |
H400 | Very toxic to aquatic life |
H401 | Toxic to aquatic life |
H402 | Harmful to aquatic life |
H410 | Very toxic to aquatic life with long-lasting effects |
H411 | Toxic to aquatic life with long-lasting effects |
H412 | Harmful to aquatic life with long-lasting effects |
H413 | May cause long-lasting harmful effects to aquatic life |
H420 | Harms public health and the environment by destroying ozone in the upper atmosphere |
Sorry,this product has been discontinued.
Home
* Country/Region
* Quantity Required :
* Cat. No.:
* CAS No :
* Product Name :
* Additional Information :