Home Cart Sign in  
Chemical Structure| 119062-05-4 Chemical Structure| 119062-05-4

Structure of Fmoc-Asp-OH
CAS No.: 119062-05-4

Chemical Structure| 119062-05-4

*Storage: {[sel_prStorage]}

*Shipping: {[sel_prShipping]}

,{[proInfo.pro_purity]}

Synonyms: (((9H-Fluoren-9-yl)methoxy)carbonyl)-L-aspartic acid

4.5 *For Research Use Only !

{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]} Purity: {[proInfo.pro_purity]}

Change View

Size Price VIP Price

DE Stock

US Stock

Asia Stock

Global Stock

In Stock
{[ item.pr_size ]} Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}

  • {[ item.pr_size ]}

In Stock

- +

Please Login or Create an Account to: See VIP prices and availability

  • 1-2 Day Shipping
  • High Quality
  • Technical Support
Product Citations

Product Citations      Show More

Gorzeń, Oliwia ; Mikołajczyk-Martinez, Agata ; Mamun, Abdulla Al ; Horbach, Natalia ; Severynovska, Olha ; Bereta, Grzegorz , et al.

Abstract: Peptidylarginine deiminases (PADs) catalyze the calcium-dependent conversion of arginine to citrulline, which affects diverse cellular processes. Among the human isoforms, PAD2 and PAD4 are particularly relevant because of their distinct tissue distributions and substrate preferences. However, the lack of isoform-selective substrates has limited our ability to discriminate between their activities in biological systems. In this study, we developed PAD2- and PAD4-selective fluorogenic peptide substrates using the Hybrid Combinatorial Substrate Library (HyCoSuL) strategy, which incorporates both natural and over 100 unnatural amino acids. Substrate specificity profiling at P4–P2 positions revealed that PAD2 tolerates a broader range of residues, particularly at the P2 position, whereas PAD4 displays more selective preferences, favoring aspartic acid at this site. Based on these insights, we designed and validated peptide substrates with high selectivity for PAD2 or PAD4, enabling isoform-specific kinetic analysis in vitro. We demonstrated the utility of these substrates in profiling activity in THP-1 macrophages, revealing dominant PAD2 activity in PMA (phorbol 12-myristate 13-acetate)/LPS (lipopolysaccharide)-stimulated monocytes. Furthermore, PAD4-mediated citrullination of vimentin modulates its susceptibility to and calpain cleavage, potentially altering its function as a damage-associated molecular pattern (DAMP). Our findings provide a framework for the development of PAD-selective inhibitors and chemical probes, enabling the precise dissection of isozyme-specific functions in health and disease.

Purchased from AmBeed: ; ;

Ritchey, Jeremy L ; Filippi, Lindsi ; Ballard, Davis ; Pei, Dehua ;

Abstract: Intracellular delivery of biological cargos, which would yield new research tools and novel therapeutics, remains an active area of research. A convenient and potentially general approach involves the conjugation of a cell-penetrating peptide to a cargo of interest. However, linear CPPs lack sufficient cytosolic entry efficiency and metabolic stability, while previous backbone cyclized CPPs have several drawbacks including the necessity for chemical synthesis and posttranslational conjugation to peptide/protein cargos and epimerization during cyclization. We report here a new class of bismuth cyclized CPPs with excellent cytosolic entry efficiencies, proteolytic stability, and potential compatibility with genetic encoding and recombinant production.

Keywords: bismuth ; cell-penetrating peptides ; drug delivery ; endosomal escape ; peptide cyclization

Purchased from AmBeed: ; 135248-89-4

Alternative Products

Product Details of [ 119062-05-4 ]

CAS No. :119062-05-4
Formula : C19H17NO6
M.W : 355.34
SMILES Code : [H][C@@](CC(O)=O)(NC(=O)OCC1C2=CC=CC=C2C2=CC=CC=C12)C(O)=O
Synonyms :
(((9H-Fluoren-9-yl)methoxy)carbonyl)-L-aspartic acid
MDL No. :MFCD00237654
InChI Key :KSDTXRUIZMTBNV-INIZCTEOSA-N
Pubchem ID :7019016

Safety of [ 119062-05-4 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335
Precautionary Statements:P261-P305+P351+P338
 

Historical Records

Categories

Similar Product of
[ 119062-05-4 ]

Chemical Structure| 287484-33-7

A987328 [287484-33-7]

Fmoc-Asp-OH--15N

Reason: Stable Isotope