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Chemical Structure| 1198355-16-6 Chemical Structure| 1198355-16-6

Structure of 1198355-16-6

Chemical Structure| 1198355-16-6

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Product Details of [ 1198355-16-6 ]

CAS No. :1198355-16-6
Formula : C13H23NO2
M.W : 225.33
SMILES Code : O=C(OC(C)(C)C)N[C@H]1CC[C@H](C=C)CC1
MDL No. :MFCD09055137

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Application In Synthesis of [ 1198355-16-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1198355-16-6 ]

[ 1198355-16-6 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 42881-66-3 ]
  • [ 1198355-16-6 ]
  • tert-butyl (trans-4-(2-(6-methoxyquinolin-4-yl)ethyl)cyclohexyl)carbamate [ No CAS ]
YieldReaction ConditionsOperation in experiment
A 3-necked round bottom flask was charged with alkene 31 (0.87 g, 3.9 mmol, 1.0 equiv) andvacuum/N2 purged. Anhydrous THF (20 mL) was added by syringe and the resulting light yellowsolution was cooled under N2 in an ice bath. 9-BBN (0.5 M in THF, 20 mL, 10 mmol, 2.6 equiv)was added slowly by syringe over 15 min. The ice bath was removed, and the solution was stirredat ambient temperature for 4 h. Excess borane was quenched by addition of water (0.1 mL). <strong>[42881-66-3]4-bromo-6-methoxyquinoline</strong> 3 (0.9347 g, 3.926 mmol, 1.0 equiv), Pd(PPh3)4 (0.55 g, 0.48 mmol,0.12 equiv), K3PO4 (5.8 g, 27 mmol, 7.0 equiv), ethanol (8 mL), and water (2 mL) were added insuccession, and the resulting mixture was heated at reflux under N2 for 16 h, then allowed to coolto room temperature. Solids were removed by decanting, and the supernatant liquid was concentrated and purified by flash chromatography (0 to 50% ethyl acetate in hexanes) to affordthe title compound as a light yellow, somewhat tacky solid (1.05 g, 2.7 mmol, 70%, slightlycontaminated with solvent).
 

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