Home Cart Sign in  
HazMat Fee +

There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.

Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
Inaccessible (Haz class 6.1), Domestic USD 80+
Inaccessible (Haz class 6.1), International USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic USD 100+
Accessible (Haz class 3, 4, 5 or 8), International USD 200+
Chemical Structure| 120-18-3 Chemical Structure| 120-18-3

Structure of 120-18-3

Chemical Structure| 120-18-3

*Storage: {[sel_prStorage]}

*Shipping: {[sel_prShipping]}

,{[proInfo.pro_purity]}

4.5 *For Research Use Only !

{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]} Purity: {[proInfo.pro_purity]}

Change View

Size Price VIP Price

US Stock

Global Stock

In Stock
{[ item.pr_size ]} Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}

US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days

  • {[ item.pr_size ]}

In Stock

- +

Please Login or Create an Account to: See VIP prices and availability

US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks

  • 1-2 Day Shipping
  • High Quality
  • Technical Support
Product Citations

Alternative Products

Product Details of [ 120-18-3 ]

CAS No. :120-18-3
Formula : C10H8O3S
M.W : 208.23
SMILES Code : O=S(C1=CC=C2C=CC=CC2=C1)(O)=O
MDL No. :MFCD00004089
Boiling Point : No data available
InChI Key :KVBGVZZKJNLNJU-UHFFFAOYSA-N
Pubchem ID :8420

Safety of [ 120-18-3 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H290-H314
Precautionary Statements:P234-P260-P264-P280-P301+P330+P331+P310-P303+P361+P353+P310+P363-P304+P340+P310-P305+P351+P338+P310-P390-P405-P406-P501
Class:8
UN#:2585
Packing Group:

Application In Synthesis of [ 120-18-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 120-18-3 ]

[ 120-18-3 ] Synthesis Path-Downstream   1~3

  • 1
  • [ 532-02-5 ]
  • [ 120-18-3 ]
YieldReaction ConditionsOperation in experiment
With Ion exchange resin (Amberlite) (H+ form); In methanol; Compound C-8 Ion exchange resin (Amberlite) (H+ form) was added to a solution of sodium 2-naphthalenesulfonate in methanol. The mixture was stirred overnight and filtered and the solvent was evaporated. The residue was lyophilized yielding 2-naphthalenesulfonic acid.
  • 2
  • [ 313368-91-1 ]
  • [ 120-18-3 ]
  • 2C10H8O3S*C24H28FN3O [ No CAS ]
YieldReaction ConditionsOperation in experiment
60% In acetone; at 20℃;Inert atmosphere; 1.5 g (3.81 mmol) of the formula (I) lumateperone base according to example 9 is dissolved in 12 ml acetone. The acetone solution of naphthalene-2-sulfonic acid monohydrate (1.726 g, 7.62 mmol) is prepared separately using 2 ml acetone. The acetone solution of naphthalene-2- sulfonic acid monohydrate is added drop by drop at room temperature to the lumateperone base solution in an argon atmosphere. A white crystalline substance precipitates. The suspension is stirred for 1 day at room temperature, then cooled in a ice and water bath, then the crystalline substance is filtered out. The product is then washed on the filter with a little cold acetone. The filtered lumateperone dinapsylate salt is dried until constant weight at 40 C, 2.5 g (83%). The raw product can be further purified using acetonitrile recrystallization (250 ml). 1.8 g (60%) white crystals, mp: 188-192 C. [OI]D25 = 4.4 (c = 1.00, DMF). HPLC purity: 99.628% (figure 8) IR (KBr): 3006, 2621, 2400, 1678, 1599, 1482, 1237, 1167, 1086, 1026, 676 cm 1. 1H-NMR (DMSO-i/e, 400 MHz): 9.10 (b, 1H), 8.14 (bs, 2* lH), 8.04 (~dd, 7i = 5.6 Hz, 72 = 8.8 Hz, 2H), 7.97 (m, 2* 1H), 7.90 (m, 2* lH), 7.86 (d, 7 = 8.5 Hz, 2* lH), 7.71 (dd, 7i =1.7 Hz, J2 = 8.5 Hz, 2* lH), 7.53 (m, 2* lH), 7.51 (m, 2* lH), 7.37 (~t, J = 8.8 Hz, 2H), 6.61 (m, 1H), 6.53 (m, 1H), 6.44 (m, 1H), 3.60 (m, 1H), 3.46 (m, 1H), 3.45 (m, 1H), 3.45 (m, 1H), 3.41 (m, 1H), 3.35 (m, 1H), 3.33 (m, 1H), 3.23 (m, 1H), 3.13 (m, 2H), 3.11 (m, 1H), 3.08 (m, 1H), 3.03 (m, 1H), 2.81 (m, 3H), 2.70 (m, 1H), 2.57 (m, 1H), 2.26 (m, 1H), 2.06 (m, 1H), 2.03 (m, 1H), 2.00 (m, 1H) ppm. 13C-NMR (DMSO- , 100 MHz): 197.37; 165,25 (d, J = 251.6 Hz); 145.74; l37.67w; l35.46w; 133.27 (d, J = 2.9 Hz); 132,90; 132.32; 131.06 (d, J = 9.5 Hz); 128.63; 127.63; 127.49; 127. l2w; 126.61; 126.47; 124.21; 124.14; l20.87w; 115 92 (d, J = 22.0 Hz); H3.42w; 1 l0.07w; 62.30; 55.72; 52.66; 50.07; 47.93; 43.74; 37.56w; 35.02; 21.88; 18.20 (w: weak) ppm. COSY: 8.14-7.71-7.86, 8.04-7.37, 7.97-7.51-7.53-7.90, 6.53-6.61-6.44, (3.60, 2.57)-3.33- 3.23-(2.26, 2.06)-(3.45, 3.03), (3.46, 3.35)-(3.4l, 2.70), 3.l3-(2.03, 2.00)-(3.l l, 3.08). HSQC (140 Hz): 8.14-124.21, 8.04-131.06, 7.97-128.63, 7.90-127.63, 7.86-127.49, 7.71- 124.14, 7.53-126.61, 7.51-126.47, 7.37-115.92, 6.61-120.87, 6.53-113.42, 6.44-110.07, 3.60- 52.66, 3.46-50.07, 3.45-47.93, 3.41-43.74,3.35-50.07, 3.33-38.81, 3.23-62.30, 3.13-35.02, 3.11-55.72, 3.08-55.72, 2.81-37.56, 2.70-43.74, 2.57-52.66, 2.26-21.88, 3.03-47.93, 2.06- 21.88, 2.03-18.20, 2.00-18.20. HMBC (140 Hz, 8 Hz): 8.14-(132.90, 128.63, 124.14), 8.04-Q97.37, 165.25, 131.06), 7.97- (132.90, 126.61), 7.90-(l32.32, 126.47), 7.86-Q45.74, 132.32), 7.71-Q32.90, 124.21), 7.53- (132.90, 128.63), 7.5l-(l32.32, 127.63), 7.37-Q65.25, 133.27, 115.92), 6.61-135.46, 6.53- 110.07, 6.44-137.67, 3.13-(197.37, 18.20), (3.11, 3.08)-l8.20. X-ray powder diffractogram: figure 7
  • 3
  • [ 313368-91-1 ]
  • [ 120-18-3 ]
  • C10H8O3S*C24H28FN3O [ No CAS ]
YieldReaction ConditionsOperation in experiment
0.92 g In acetone; at 20℃; for 24h;Inert atmosphere; Cooling with ice; 1.00 g (2.54 mmol) formula (I) lumateperone base according to example 9 is dissolved in 6 ml acetone and in an argon atmosphere 0.575 g (2.54 mmol) naphthalene-2-sulfonic acid monohydrate is added to this in a single portion. The salt precipitates almost immediately after the acid has been dissolved. The suspension is stirred at room temperature for 24 hours, then cooled for 30 minutes in an ice and water bath. The salt is filtered using a glass filter, then washed with about 0.5 ml cold acetone. 1.10 g mononapsylate is obtained, which is purified further by recrystallization from 60 ml isopropanol. 0.92 g white crystalline product is obtained, mp: 165-172 C. lHNMR (DMSO- e, 400 MHz): 8.14 (d, J= 0.6 Hz, 1H), 8.04 (~dd, J = 5.5 Hz, j2 = 9.0 Hz, 2H), 7.97 (m, 1H), 7.90 (m, 1H), 7.86 (d, j= 8.6 Hz, 1H), 7.71 (dd, L = 1.6 Hz, j2 = 8.5 Hz, 1H), 7.52 (m, 2H), 7.37 (~t, J= 8.9 Hz, 2H), 6.60 (m, 1H), 6.52 (m, 1H), 6.43 (m, 1H), 3.60 (m, 1H), 3.46 (m, 1H), 3.45 (m, 1H), 3.41 (m, 1H), 3.32 (m, 1H), 3.31 (m, 1H), 3.23 (m, 1H), 3.12 (m, 2H), 3.10 (m, 1H), 3.08 (m, 1H), 3.03 (m, 1H), 2.81 (s, 3H), 2.71 (m, 1H), 2.57 (m, 1H), 2.25 (m, lH), 2.06 (m, 1H), 2.02 (m, 2H) ppm.
 

Historical Records

Technical Information

Categories