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Chemical Structure| 1203683-50-4 Chemical Structure| 1203683-50-4

Structure of 1203683-50-4

Chemical Structure| 1203683-50-4

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Product Details of [ 1203683-50-4 ]

CAS No. :1203683-50-4
Formula : C13H17NO2
M.W : 219.28
SMILES Code : O=C(C1=CC=CC2=C1CNCC2(C)C)OC
MDL No. :MFCD16619001

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Application In Synthesis of [ 1203683-50-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1203683-50-4 ]

[ 1203683-50-4 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 1235036-15-3 ]
  • [ 1203683-50-4 ]
  • [ 1430845-93-4 ]
YieldReaction ConditionsOperation in experiment
With triethylamine; In dimethyl sulfoxide; at 100℃; Example 14A methyl 2-(5-bromo-6-(tert-butoxycarbonyl)pyridin-2-yl)-4,4-dimethyl-1,2,3,4-tetrahydroisoquinoline-8-carboxylate Methyl 4,4-dimethyl-1,2,3,4-tetrahydroisoquinoline-8-carboxylate (500 mg), EXAMPLE 1D (572 mg), and triethylamine (0.545 mL) in anhydrous dimethylsulfoxide (6.5 mL) was heated to 100 C. overnight, and the mixture was then cooled to room temperature. The reaction was quenched by the addition of saturated aqueous sodium bicarbonate solution (15 mL) and ethyl acetate (15 mL). The layers were separated, and the aqueous layer was extracted with additional ethyl acetate (2*15 mL). The combined organics were dried with anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The residue was purified by chromatography on silica gel with 0-40% ethyl acetate/hexanes to provide the title product.
 

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