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Chemical Structure| 1204501-41-6 Chemical Structure| 1204501-41-6

Structure of 1204501-41-6

Chemical Structure| 1204501-41-6

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Product Details of [ 1204501-41-6 ]

CAS No. :1204501-41-6
Formula : C13H9ClN2O2S
M.W : 292.74
SMILES Code : O=S(N1C=CC2=CC(Cl)=NC=C12)(C3=CC=CC=C3)=O

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Application In Synthesis of [ 1204501-41-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1204501-41-6 ]

[ 1204501-41-6 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 1204501-41-6 ]
  • [ 503184-35-8 ]
  • [ 1612287-86-1 ]
YieldReaction ConditionsOperation in experiment
72% With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; caesium carbonate; In 1,4-dioxane; at 100℃; for 6h;Schlenk technique; Inert atmosphere; General procedure: An oven dried resealable Schlenk tube was charged with 5-bromo-2-chloro-1H-pyrrolo[2,3-b]pyridine (Preparation 1c, 0.5 g, 2.07 mmol), <strong>[503184-35-8](6-methoxy-4-methylpyridin-3-yl)boronic acid</strong> (Preparation 2, 0.35 g, 2.08 mmol), cesium carbonate (2.027 g, 6.22 mmol), 5.5 ml dioxane and 5.5 ml water. The Schlenk tube was subjected to three cycles of evacuation-backfilling with argon, and 1,1'-bis(diphenylphosphino)ferrocene-palladium(II) dichloride dichloromethane complex (0.085 g, 0.10 mmol) was added. After three further cycles of evacuation-backfilling with argon, the Schlenk tube was capped and placed in an oil bath at 100 C. After 6h, the mixture was cooled and the solvent was removed in vacuo. Water was added and product was extracted with dichloromethane and organic layer was dried (Na2SO4). The residue was purified by flash chromatography (10%, dichloromethane-methanol) to give the title compound (0.353 g, 62% yield) as a solid. LRMS (m/z):274 (M+1)+. 5-Chloro-1-(phenylsulfonyl)-1H-pyrrolo[2,3-c]pyridine (Preparation 52a) was treated with <strong>[503184-35-8](6-methoxy-4-methylpyridin-3-yl)boronic acid</strong>, 2M cesium carbonate, [1,1'-bis(diphenylphosphino)ferrocene]dichloropalladium(II) complex with dichloromethane and dioxane as a solvent according to the method described in Preparation 3a. The crude was purified by flash chromatography using SP1 Purification System (0% to 100%, hexane-diethyl ether) to give the title compound (72% yield) as a yellow solid. LRMS (m/z): 380 (M+1)+
 

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