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Type | HazMat fee for 500 gram (Estimated) |
Excepted Quantity | USD 0.00 |
Limited Quantity | USD 15-60 |
Inaccessible (Haz class 6.1), Domestic | USD 80+ |
Inaccessible (Haz class 6.1), International | USD 150+ |
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Accessible (Haz class 3, 4, 5 or 8), International | USD 200+ |
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CAS No. : | 1208-87-3 | MDL No. : | MFCD09907764 |
Formula : | C13H11ClS | Boiling Point : | - |
Linear Structure Formula : | - | InChI Key : | RLFHPRWHJYDGSD-UHFFFAOYSA-N |
M.W : | 234.74 | Pubchem ID : | 71022 |
Synonyms : |
|
Num. heavy atoms : | 15 |
Num. arom. heavy atoms : | 12 |
Fraction Csp3 : | 0.08 |
Num. rotatable bonds : | 3 |
Num. H-bond acceptors : | 0.0 |
Num. H-bond donors : | 0.0 |
Molar Refractivity : | 66.77 |
TPSA : | 25.3 Ų |
GI absorption : | High |
BBB permeant : | Yes |
P-gp substrate : | No |
CYP1A2 inhibitor : | Yes |
CYP2C19 inhibitor : | Yes |
CYP2C9 inhibitor : | Yes |
CYP2D6 inhibitor : | No |
CYP3A4 inhibitor : | No |
Log Kp (skin permeation) : | -4.62 cm/s |
Log Po/w (iLOGP) : | 2.89 |
Log Po/w (XLOGP3) : | 4.38 |
Log Po/w (WLOGP) : | 4.42 |
Log Po/w (MLOGP) : | 4.95 |
Log Po/w (SILICOS-IT) : | 4.59 |
Consensus Log Po/w : | 4.25 |
Lipinski : | 1.0 |
Ghose : | None |
Veber : | 0.0 |
Egan : | 0.0 |
Muegge : | 1.0 |
Bioavailability Score : | 0.55 |
Log S (ESOL) : | -4.45 |
Solubility : | 0.00835 mg/ml ; 0.0000356 mol/l |
Class : | Moderately soluble |
Log S (Ali) : | -4.63 |
Solubility : | 0.00553 mg/ml ; 0.0000236 mol/l |
Class : | Moderately soluble |
Log S (SILICOS-IT) : | -6.05 |
Solubility : | 0.000208 mg/ml ; 0.000000887 mol/l |
Class : | Poorly soluble |
PAINS : | 0.0 alert |
Brenk : | 1.0 alert |
Leadlikeness : | 2.0 |
Synthetic accessibility : | 1.69 |
Signal Word: | Danger | Class: | 8 |
Precautionary Statements: | P260-P264-P270-P280-P301+P330+P331-P303+P361+P353-P304+P340-P305+P351+P338-P310-P363-P405-P501 | UN#: | 3265 |
Hazard Statements: | H302-H314 | Packing Group: | Ⅱ |
GHS Pictogram: |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
97.7% | With pyridine; thionyl chloride In dichloromethane at 20 - 25℃; for 2 h; Cooling with ice | 518.0 g of 4-phenylmercaptobenzyl alcohol, 147 ml of pyridine and 2444 ml of dichloromethane were charged into a 5000 mL reaction flask at room temperature (25 ° C.), and the mixture was cooled in ice water to control the temperatureThionyl chloride was added dropwise at 20-24 ° C and the mixture was stirred at room temperature (25 ° C) for 2 hours. TLC (n-hexane: ethyl acetate = 10: 1) was carried out to the end of the reaction. Washed with water, neutralized with water, dried over anhydrous magnesium sulfate, filtered and the filtrate was concentrated under reduced pressure (pressure 1720 Pa, temperature 25 ° C) to dryness. Methylene chloride was recovered to obtain 548.0 g of brownish red oil with a yield of 97.7percent and HPLC purity of 99.66 percent. (Frozen to about -10 curable). |
96.7% | With pyridine; thionyl chloride In dichloromethane at 20 - 24℃; for 2.5 h; | The 4-benzoquinone benzyl alcohol, pyridine, and dichloromethane were put into the reaction flask at room temperature (25 °C), ice-cooled and cooled at 20-24 °C, thionyl chloride was added dropwise, and the mixture was stirred at 25° C for 2 hours. Thin layer detection (n-hexane:ethyl acetate=10:1) to the end of the reaction, washing with water to neutrality, drying the dichloromethane layer over anhydrous magnesium sulfate, filtering, and depressurizing the filtrate (pressure 1720 Pa, temperature 25 °C) To dryness, the methylene chloride was recovered to give a brown-red oil (frozen to about -10 °C or so). See Table 4 for details |
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