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Chemical Structure| 121194-51-2 Chemical Structure| 121194-51-2

Structure of 121194-51-2

Chemical Structure| 121194-51-2

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Product Details of [ 121194-51-2 ]

CAS No. :121194-51-2
Formula : C15H13N
M.W : 207.27
SMILES Code : C1(NCC#CC2=CC=CC=C2)=CC=CC=C1

Safety of [ 121194-51-2 ]

Application In Synthesis of [ 121194-51-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 121194-51-2 ]

[ 121194-51-2 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 1195-33-1 ]
  • [ 121194-51-2 ]
  • 3-((4-bromophenyl)sulfonyl)-4-phenylquinoline [ No CAS ]
  • 2
  • [ 121194-51-2 ]
  • [ 14752-66-0 ]
  • 3-((4-chlorophenyl)sulfonyl)-4-phenylquinoline [ No CAS ]
YieldReaction ConditionsOperation in experiment
80% With tert.-butylhydroperoxide; copper(l) iodide; tetra(n-butyl)ammonium hydrogensulfate; In acetic acid; 1,2-dichloro-ethane; at 70℃; for 12h; 41.4 mg (0.2 mmol) of N- (3-phenylprop-2-yn-1-yl) aniline, 59.6 mg (0.3 mmol) of <strong>[14752-66-0]sodium 4-chlorobenzenesulfinate</strong>, 3.8 mg (10% mol) of iodination Cuprous, 36.0 mg (2 equivalents) of t-butyl hydroperoxide, 13.6 mg (20% mol) of tetrabutylammonium hydrogen sulfate, 60 mg (5 equivalents) of glacial acetic acid in 2 mL of solvent 1,2-dichloroethane . The reaction was stirred at 70 C for 12 hours. After the reaction was completed, the reaction solution was cooled, the reaction solution was filtered to obtain a filtrate, and the filtrate was subjected to rotary evaporation.The solvent was removed to obtain a residue, and the residue was subjected to silica gel column chromatography.Rinse with a mixed solution of petroleum ether and ethyl acetate in a volume ratio of 6: 1, collect the effluent according to the actual gradient, and detect by TLC.Combine the product-containing effluents,The solvent was distilled off on a rotary evaporator,Vacuum drying gave a white solid,3-((4-chlorophenyl) sulfonyl) -4-phenylquinoline 60.6 mg,Yield 80%
 

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