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Chemical Structure| 1214361-12-2 Chemical Structure| 1214361-12-2

Structure of 1214361-12-2

Chemical Structure| 1214361-12-2

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Product Details of [ 1214361-12-2 ]

CAS No. :1214361-12-2
Formula : C9H6ClF3O2
M.W : 238.59
SMILES Code : COC(=O)C1=CC(Cl)=CC(=C1)C(F)(F)F
MDL No. :MFCD04115849

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Application In Synthesis of [ 1214361-12-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1214361-12-2 ]

[ 1214361-12-2 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 22227-63-0 ]
  • [ 1214361-12-2 ]
  • 2
  • [ 22235-25-2 ]
  • [ 1214361-12-2 ]
YieldReaction ConditionsOperation in experiment
Reference Example 29 Methyl 3-chloro-5-(trifluoromethyl)benzoate To a stirred solution of <strong>[22235-25-2]methyl 3-amino-5-(trifluoromethyl)benzoate</strong> (Reference Example 28, 2.15 g, 9.81 mmol) in acetonitrile (50.0 mL) was added tert-butyl nitrite (3.04 g, 29.48 mmol) at room temperature. After 15 min copper(II) chloride (2.38 g, 17.70 mmol) was added and the reaction mixture was stirred overnight. After this time, the mixture was diluted with ethyl acetate, washed with water, saturated ammonium hydrochloride, and saturated sodium chloride, dried (Na2SO4), filtered and concentrated under reduced pressure to provide methyl 3-chloro-5-(trifluoromethyl)benzoate (2.20 g, 94%) as a brown oil, which was used without further purification or characterization.
 

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