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Type HazMat fee for 500 gram (Estimated)
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Chemical Structure| 1217800-70-8 Chemical Structure| 1217800-70-8

Structure of 1217800-70-8

Chemical Structure| 1217800-70-8

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Product Details of [ 1217800-70-8 ]

CAS No. :1217800-70-8
Formula : C7H3Cl2FO
M.W : 193.00
SMILES Code : O=CC1=CC(Cl)=C(Cl)C=C1F
MDL No. :MFCD28785955

Safety of [ 1217800-70-8 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H301-H311-H331
Precautionary Statements:P261-P264-P270-P271-P280-P302+P352-P304+P340-P310-P330-P361-P403+P233-P405-P501
Class:6.1
UN#:2811
Packing Group:

Application In Synthesis of [ 1217800-70-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1217800-70-8 ]

[ 1217800-70-8 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 13472-83-8 ]
  • [ 1217800-70-8 ]
  • 4,5-dichloro-2-[(2-methoxy-3-pyridyl)oxy]benzaldehyde [ No CAS ]
YieldReaction ConditionsOperation in experiment
84% With caesium carbonate; In N,N-dimethyl-formamide; at 75℃; for 0.166667h; A mixture of 4,5-dichloro-2-fluoro-benzaldehyde (502 mg, 2.60 mmol), 2-methoxypyridin-3- ol (325 mg, 2.60 mmol) and cesium carbonate (1.02 g, 3.12 mmol) in DMF (4 mL) was heated at 75 C for 10 minutes. The cooled reaction mixture was diluted with ethyl acetate (50 mL) then partitioned with water (50 mL). The aqueous portion was extracted with ethyl acetate (2 x 25 mL) and the combined organics were washed with saturated sodium chloride solution (2 x 25 mL), dried over sodium sulfate concentrated in vacuo. The product was purified by silica gel chromatography (0-100% ethyl acetate/hexanes) to provide 4,5-dichloro-2-[(2-methoxy-3-pyridyl)oxy]benzaldehyde (650 mg, 84%). ESI-MS m/z calc. 297.00, found 298.1 (M+l)+; Retention time (Method A): 0.68 minutes (1 minutes run). 1H NMR (400 MHz, DMSO-d6) 5 10.35 (s, 1H), 8.12 (dd, J = 5.0, 1.6 Hz, 1H), 7.97 (s, 1H), 7.70 (dd, J = 7.7, 1.6 Hz, 1H), 7.14 - 7.08 (m, 2H), 3.87 (s, 3H) ppm
 

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