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Chemical Structure| 122483-59-4 Chemical Structure| 122483-59-4

Structure of 122483-59-4

Chemical Structure| 122483-59-4

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Product Details of [ 122483-59-4 ]

CAS No. :122483-59-4
Formula : C8H3Cl2NO
M.W : 200.02
SMILES Code : O=C(Cl)C1=CC(C#N)=CC=C1Cl
MDL No. :MFCD13174395

Safety of [ 122483-59-4 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H302-H314
Precautionary Statements:P264-P270-P271-P280-P303+P361+P353-P304+P340-P305+P351+P338-P310-P330-P331-P363-P403+P233-P501
Class:8
UN#:3261
Packing Group:

Application In Synthesis of [ 122483-59-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 122483-59-4 ]

[ 122483-59-4 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 122483-59-4 ]
  • [ 21203-86-1 ]
  • 2-chloro-5-cyano-N-(2-phenylpyridin-4-yl)benzamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
59.1% With triethylamine; In dichloromethane; at 40℃; 2-chloro-5-cyanobenzoyl chloride (55.1 mg, 0.27 mmol) in dry 113 DCM was added dropwise in a cooling mixture of 16 <strong>[21203-86-1]2-phenylpyridin-4-amine</strong> (42.5 mg, 0.25 mmol), 73 triethylamine (0.05 mL, 0.37 mmol) in 1 mL of dry DCM. The reaction mixture was stirred at 40C overnight. The mixture was extracted with DCM and NaHCO3 saturated. The organic layer was dried (Na2SO4) and concentrated. The crude was purified by CombiFlash column chromatography (Cyclohexane/ethyl acetate) to afford the 114 amide derivative (54.2, 59.1%). 1H-NMR (400 MHz, DMSO-d6): delta = 11.11 (s, 1 H), 8.61 (d, 1 H), 8.29 (d, 1 H), 8.20 (s, 1 H), 8.05 (dd, 1 H), 7.99 (d, 2H), 7.86 (d, 1 H), 7.64 (d, 1 H), 7.52 (t, 2H), 7.46 (t, 1H). HPLC-MS: Rt 4.737; m/z 333.8 (MH+).
 

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