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Chemical Structure| 1225346-74-6 Chemical Structure| 1225346-74-6

Structure of 1225346-74-6

Chemical Structure| 1225346-74-6

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Product Details of [ 1225346-74-6 ]

CAS No. :1225346-74-6
Formula : C14H13NO3
M.W : 243.26
SMILES Code : O=C1OC[C@@](C)(C2=CC=C3C=C(O)C=CC3=C2)N1
MDL No. :MFCD13180458

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Application In Synthesis of [ 1225346-74-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1225346-74-6 ]

[ 1225346-74-6 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 1225346-74-6 ]
  • [ 54410-90-1 ]
  • [ 1226494-75-2 ]
YieldReaction ConditionsOperation in experiment
68% (R)-4-(6-Hydroxnaphthalen-2-yl)-4-methyl-oxazolidin-2-one (Example 4, 0.3303 g, 0.001358 mol) was added to a capped 40 mL vial equipped with a magnetic stir bar. 4-o Pentyl-cyclohexanol (0.277 g, 0.00163 mol) was added, followed by tetrahydrofuran (6.00 mL, 0.0740 mol). Triphenylphosphine polymer-bound (1.17 g, 0.00217 mol) was then added and the mixture was stirred for 5 minutes. Diisopropyl azodicarboxylate (0.428 mL, 0.00217 mol) was then added and the mixture was stirred for 48 hours at room temperature. The mixture was diluted in ethyl acetate, filtered through CELITE, concentrated unders vacuum and purified by flash chromatography (0-5% MeOH in dichloromethane) to give 0.3672 g of the title compound (68% yield).
 

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