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Chemical Structure| 1229224-93-4 Chemical Structure| 1229224-93-4

Structure of 1229224-93-4

Chemical Structure| 1229224-93-4

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Product Details of [ 1229224-93-4 ]

CAS No. :1229224-93-4
Formula : C22H26F3N
M.W : 361.44
SMILES Code : FC(C1=CC(CCCN[C@@H](C2=C3CCCCC3=CC=C2)C)=CC=C1)(F)F
MDL No. :MFCD28167920
InChI Key :DYEQMULKZQBEKD-MRXNPFEDSA-N
Pubchem ID :46234195

Safety of [ 1229224-93-4 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P280-P301+P312-P302+P352-P305+P351+P338

Application In Synthesis of [ 1229224-93-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1229224-93-4 ]

[ 1229224-93-4 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 226256-56-0 ]
  • [ 1229224-93-4 ]
YieldReaction ConditionsOperation in experiment
With hydrogen;Raney-Ni; In methanol; at 75 - 80℃; under 8826.87 - 11033.6 Torr; for 16.0h; Example 14; Preparation of (R)-α-methyl-N-[3-[3-(trifluoromethyl)phenyl]propyl]-l-(5,6,7,8- tetrahydronaphthalene)methane amine hydrochloride (Tetrahydro Cinacalcet hydrochloride) A solution of cinacalcet base (15 g) in methanol (150 ml) was hydrogenated with raney-Ni catalyst (10 g) at 12-15 kg pressure at 75-8O0C for 16 hours. The catalyst was filtered off and the filtrate was concentrated under vacuum at below 500C to get crude product (16 g). The crude product was crystallized from heptane (100 ml) to obtain the free base of tetrahydro cinacalcet. The base was dissolved in acetonitrile (25 ml) and a mixture of concentrated hydrochloric acid (3 g) and water (50 ml) was added at 25-3O0C. The reaction mixture was cooled to 0-50C and the precipitated product was filtered and washed with water and then dried under vacuum at 45-500C to provide 0.75 g of tetrahydro cinacalcet hydrochloride (Purity by HPLC: 96.5%).
  • 2
  • [ 1229224-93-4 ]
  • [ 1229225-43-7 ]
YieldReaction ConditionsOperation in experiment
With hydrogenchloride; In water; acetonitrile; at 25 - 30℃; Example 14; Preparation of (R)-α-methyl-N-[3-[3-(trifluoromethyl)phenyl]propyl]-l-(5,6,7,8- tetrahydronaphthalene)methane amine hydrochloride (Tetrahydro Cinacalcet hydrochloride) A solution of cinacalcet base (15 g) in methanol (150 ml) was hydrogenated with raney-Ni catalyst (10 g) at 12-15 kg pressure at 75-8O0C for 16 hours. The catalyst was filtered off and the filtrate was concentrated under vacuum at below 500C to get crude product (16 g). The crude product was crystallized from heptane (100 ml) to obtain the free base of tetrahydro cinacalcet. The base was dissolved in acetonitrile (25 ml) and a mixture of concentrated hydrochloric acid (3 g) and water (50 ml) was added at 25-3O0C. The reaction mixture was cooled to 0-50C and the precipitated product was filtered and washed with water and then dried under vacuum at 45-500C to provide 0.75 g of tetrahydro cinacalcet hydrochloride (Purity by HPLC: 96.5%).
 

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