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Chemical Structure| 1235406-89-9 Chemical Structure| 1235406-89-9

Structure of 1235406-89-9

Chemical Structure| 1235406-89-9

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Product Details of [ 1235406-89-9 ]

CAS No. :1235406-89-9
Formula : C17H14F3N3O4S2
M.W : 445.44
SMILES Code : O=S(C1=CC(F)=C(F)C=C1F)(N(CC2=CC=C(OC)C=C2OC)C3=NC=NS3)=O
MDL No. :MFCD22201200

Safety of [ 1235406-89-9 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P280-P301+P312-P302+P352-P305+P351+P338

Application In Synthesis of [ 1235406-89-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1235406-89-9 ]

[ 1235406-89-9 ] Synthesis Path-Downstream   1~4

  • 1
  • [ 349-58-6 ]
  • [ 1235406-89-9 ]
  • 4-[3,5-bis(trifluoromethyl)phenoxy]-N-[(2,4-dimethoxyphenyl)methyl]-2,5-difluoro-N-(1,2,4-thiadiazol-5-yl)benzene-1-sulfonamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
45% With caesium carbonate; In dimethyl sulfoxide; at 25℃; for 2h; N-[(2,4-dimethoxyphenyl)methyl]-2,4,5-trifluoro-N-(1 ,2, 4-thiadiazol-5-yl)benzene-1 -sulfonamide (150 mg, 0.34 mmol, 1 .00 equiv), 3,5-bis(trifluoromethyl)phenol (77.5 mg, 0.34 mmol, 1 .00 equiv), and Cs2C03 (164.8 mg, 0.51 mmol, 1 .50 equiv) were dissolved in 3 mL of DMSO. The resulting reaction was stirred for 2 hours at 25 °C and then quenched by the addition of water. The mixture was then extracted with ethyl acetate and the combined organic layers were washed with brine, dried over anhydrous sodium sulfate and concentrated in vacuo. This resulted in 100 mg (45percent) of 4-[3,5-bis(trifluoromethyl)phenoxy]- N-[(2,4-dimethoxyphenyl)methyl]-2,5-difluoro-N-(1 ,2,4-thiadiazol-5-yl)benzene-1 -sulfonamide as a yellow oil.
  • 2
  • [ 349-58-6 ]
  • [ 1235406-89-9 ]
  • 4-[3,5-bis(trifluoromethyl)phenoxy]-2,5-difluoro-N-(1,2,4-thiadiazol-5-yl)benzene-1-sulfonamide trifluoroacetate [ No CAS ]
  • 3
  • [ 1025718-84-6 ]
  • [ 1235406-89-9 ]
  • 4-[3-bromo-5-(trifluoromethyl)phenoxy]-N-[(2,4-dimethoxyphenyl)methyl]-2,5-difluoro-N-(1,2,4-thiadiazol-5-yl)benzene-1-sulfonamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
76% With caesium carbonate; In N,N-dimethyl-formamide; at 20℃; for 16.0h; Into a 50-m L round-bottom flask, was placed a solution of N-[(2,4-dimethoxyphenyl)methyl]-2,4,5- trifluoro-N-(1 ,2,4-thiadiazol-5-yl)benzene-1 -sulfonamide (150 mg, 0.34 mmol, 1 .00 equiv) in N,N- dimethylformamide (20 mL). To the solution were added <strong>[1025718-84-6]3-bromo-5-(trifluoromethyl)phenol</strong> (81 mg, 0.34 mmol, 1 .00 equiv) and Cs2C03 (220 mg, 0.67 mmol, 2.00 equiv). The resulting solution was stirred for 16 h at room temperature. The resulting solution was extracted with ethyl acetate (3x20 m L) and the organic layers combined and concentrated under vacuum . The residue was applied onto a silica gel column with ethyl acetate/petroleum ether (1 :5). This resulted in 170 mg (76%) of 4-[3-bromo-5- (0624) (trifluoromethyl)phenoxy]-N-[(2,4-dimethoxyphenyl)methyl]-2,5-difluoro-N-(1 ,2,4-thiadiazol-5-yl)benzene- 1 -sulfonamide as a white solid.
  • 4
  • [ 1025718-84-6 ]
  • [ 1235406-89-9 ]
  • 4-[3-bromo-5-(trifluoromethyl)phenoxy]-2,5-difluoro-N-(1,2,4-thiadiazol-5-yl)benzene-1-sulfonamide [ No CAS ]
 

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