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Chemical Structure| 1243245-69-3 Chemical Structure| 1243245-69-3

Structure of 1243245-69-3

Chemical Structure| 1243245-69-3

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Product Details of [ 1243245-69-3 ]

CAS No. :1243245-69-3
Formula : C14H13NO2
M.W : 227.26
SMILES Code : O=C(O)CC1=CC=C(C2=CC(C)=NC=C2)C=C1
MDL No. :MFCD22201168

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Application In Synthesis of [ 1243245-69-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1243245-69-3 ]

[ 1243245-69-3 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 52023-68-4 ]
  • [ 1243245-69-3 ]
  • [ 1243244-02-1 ]
YieldReaction ConditionsOperation in experiment
With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20℃; for 2h; A mixture of 2-(4-(2-methylpyridin-4-yl)phenyl)acetic acid 73-1 (40 mg, 0.18 mmol), 6-morpholinopyridin-3-amine (40 mg, 0.22 mmol) and HATU (80 mg, 0.21 mmol) in 2 mL DMF was added DIEA (104 muL, 0.6 mmol) at room temperature. The mixture was stirred at room temperature for 2 hours. The solvent was removed by rotary evaporation. The crude product was purified by reverse phase HPLC to give the title compound 73 as white solid. MS m/z 389.19 (M + 1); 1H NMR 400 MHz (DMSO-d6) deltal l.30(s, IH), 8.82(d, IH, J = 6.4Hz), 8.57 (d, IH, J = 2.4Hz), 8.35(m, IH), 8.24(dd, IH, Ji = 6.4 Hz, J2 = 1.6 Hz), 8.19(dd, IH, Ji = 10.0 Hz, J2 = 2.8 Hz), 8.02(m, 2H), 7.63(m, 2H), 7.42(d, 2H, J = 9.6 Hz), 3.87(s, 2H), 3.75(m, 4H), 3.66(m, 4H), 2.80(s, 3H).
 

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