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Chemical Structure| 1246891-69-9 Chemical Structure| 1246891-69-9

Structure of 1246891-69-9

Chemical Structure| 1246891-69-9

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Product Details of [ 1246891-69-9 ]

CAS No. :1246891-69-9
Formula : C11H11N3O
M.W : 201.23
SMILES Code : C12=C(OC(C3=NC=CC=C3)=N2)CCNC1

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* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1246891-69-9 ]

[ 1246891-69-9 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 10386-27-3 ]
  • [ 1246891-69-9 ]
  • [ 1247879-35-1 ]
YieldReaction ConditionsOperation in experiment
17% With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 100℃; for 16h; To a solution of 2-(pyridin-2-yl)-4,5,6,7-tetrahydrooxazolo[4,5-c] pyridine (I- 23.4) (40 mg, 0.2 mmol) in DMF (2 mL) was added <strong>[10386-27-3]2-bromoisonicotinonitrile</strong> (54 mg, 0.3 mmol), DIEA (52 mg, 0.4 mmol). The mixture was heated to 1000C and stirred for 16 h. The mixture was cooled to room temperature and poured into water. The mixture was extracted with EtOAc. The combined organic phase was dried over anhydrous Na2SO4 and concentrated. The residue was purified by preparative TLC to afford 2-(2- (pyridin-2-yl)-6,7-dihydrooxazolo[4,5-c]pyridin-5(4H)-yl)isonicotinonitrile (10 mg, 17percent) as a yellow solid. 1H NMR (400 MHz, CDCl3): delta 8.67 (d, IH), 8.25 (d, IH), 8.03 (d, IH), 7.75 (t, IH), 7.30 (t, IH), 6.81 (s, IH), 6.75 (d, IH), 4.52 (s, 2H), 4.07 (t, 2H), 2.91 (t, 2H); LC/MS: m/e = 304 (M+H)+.
 

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