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Chemical Structure| 125035-34-9 Chemical Structure| 125035-34-9

Structure of 125035-34-9

Chemical Structure| 125035-34-9

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Product Details of [ 125035-34-9 ]

CAS No. :125035-34-9
Formula : C10H6ClNOS
M.W : 223.68
SMILES Code : O=C(C1=CC=CN=C1Cl)C2=CC=CS2
MDL No. :MFCD02260467

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Application In Synthesis of [ 125035-34-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 125035-34-9 ]

[ 125035-34-9 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 125035-34-9 ]
  • [ 539-15-1 ]
  • [ 110-17-8 ]
  • [ 129182-57-6 ]
YieldReaction ConditionsOperation in experiment
In N-methyl-acetamide; ethanol; ethyl acetate; EXAMPLE 1 In 10 ml of dimethylformamide is suspended 0.82 g of 60% sodium hydride, and a solution of 3.4 g of 4-[2-(dimethylamino)ethyl]phenol in 10 ml of dimethylformamide is added dropwise to the suspension. The mixture is stirred at 60 C. for 2 hours. Thereto, a solution of 3.8 g of 2-chloro-3-(2-thenoyl)pyridine in 10 ml of dimethylformamide is added dropwise under ice-cooling. The mixture is stirred at 70 C. for 2 hours, and then is poured into ice-water, whereto ethyl acetate is added. The ethyl acetate layer is extracted with a dilute hydrochloric acid and the extract is rendered alkaline with potassium carbonate. The isolated oily substance is extracted with ethyl acetate. After the extract is washed with water and dried over anhydrous magnesium sulfate, the solvent is distilled off. The obtained residue is converted into its salt with fumaric acid in ethanol, and the salt is recrystallized from ethanol to give 2-[4-(2-dimethylaminoethyl)phenoxy]-3-(2-thenoyl)pyridine 1/2 fumarate, m.p. 147-150 C.
 

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