[ CAS No. 1256345-69-3 ] {[proInfo.proName]}

Name: 1256345-69-3|(3-(2-Ethoxy-2-oxoethyl)phenyl)boronic acid|95%
Brand: Ambeed
SKU: A257556
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2D 3D

Structure of 1256345-69-3 * Storage: {[proInfo.prStorage]}

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Quality Control of [ 1256345-69-3 ]

COA NMR CNMR HPLC LC-MS

Related Doc. of [ 1256345-69-3 ]

SDS Specification

Alternatived Products of [ 1256345-69-3 ]

Product Details of [ 1256345-69-3 ]

CAS No. :	1256345-69-3	MDL No. :	MFCD08704681
Formula :	C₁₀H₁₃BO₄	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	GDWZKERCECMYJX-UHFFFAOYSA-N
M.W :	208.02	Pubchem ID :	53216302
Synonyms :

Calculated chemistry of [ 1256345-69-3 ]

Physicochemical Properties

Num. heavy atoms :	15
Num. arom. heavy atoms :	6
Fraction Csp3 :	0.3
Num. rotatable bonds :	5
Num. H-bond acceptors :	4.0
Num. H-bond donors :	2.0
Molar Refractivity :	56.94
TPSA :	66.76 Å²

Pharmacokinetics

GI absorption :	High
BBB permeant :	No
P-gp substrate :	No
CYP1A2 inhibitor :	No
CYP2C19 inhibitor :	No
CYP2C9 inhibitor :	No
CYP2D6 inhibitor :	No
CYP3A4 inhibitor :	No
Log Kp (skin permeation) :	-6.87 cm/s

Lipophilicity

Log Po/w (iLOGP) :	0.0
Log Po/w (XLOGP3) :	0.98
Log Po/w (WLOGP) :	-0.53
Log Po/w (MLOGP) :	0.55
Log Po/w (SILICOS-IT) :	-0.16
Consensus Log Po/w :	0.17

Druglikeness

Lipinski :	0.0
Ghose :	None
Veber :	0.0
Egan :	0.0
Muegge :	0.0
Bioavailability Score :	0.55

Water Solubility

Log S (ESOL) :	-1.71
Solubility :	4.03 mg/ml ; 0.0194 mol/l
Class :	Very soluble
Log S (Ali) :	-1.97
Solubility :	2.23 mg/ml ; 0.0107 mol/l
Class :	Very soluble
Log S (SILICOS-IT) :	-2.18
Solubility :	1.37 mg/ml ; 0.00659 mol/l
Class :	Soluble

Medicinal Chemistry

PAINS :	0.0 alert
Brenk :	1.0 alert
Leadlikeness :	1.0
Synthetic accessibility :	2.19

Safety of [ 1256345-69-3 ]

Signal Word:	Warning	Class:	N/A
Precautionary Statements:	P280-P305+P351+P338	UN#:	N/A
Hazard Statements:	H302	Packing Group:	N/A
GHS Pictogram:

Application In Synthesis of [ 1256345-69-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 1256345-69-3 ]

[ 1256345-69-3 ] Synthesis Path-Downstream 1~5

1
[ 1256345-69-3 ]
[ 1454928-46-1 ]
[ 589-15-1 ]
[ 1454928-59-6 ]

Yield	Reaction Conditions	Operation in experiment
		Under a nitrogen atmosphere, 3-(3-(4-bromophenyl)propyl)-4-ethyl-lH-l,2,4-triazol-5(4H)- one (0.20 g, 0.65 mmol), Pd(PPh)4 (0.056 g, 0.065 mmol), KF (0.17 g, 2.84 mmol), (3-(2-ethoxy-2- oxoethyl)phenyl)boronic acid (0.296 g, 1.42 mmol), toluene (4 mL) and water (4 mL) were combined and the resulting mixture was stirred under nitrogen at 100 C for 16 hrs. The reaction mixture was then cooled to rt, diluted with EtOAc and washed with a 50% brine/50% water solution. The organic phase was separated, washed once more with brine, filtered through a Na2S04/paper plug, and the filtrate concentrated in vacuo. The residue was thus obtained was purified by column chromatography using a l%>-9%> gradient MeOH/DCM as eluent to afford 0.190 g of ethyl 2-(4'-(3-(4-ethyl-5-oxo-4,5-dihydro-lH-l,2,4-triazol-3- yl)propyl)-[l,l'-biphenyl]-3-yl)acetate (contaminated with unreacted starting material which coeluted). This was used as is in the next step. [00154] Step 2; To a solution of ethyl 2-(4'-(3-(4-ethyl-5-oxo-4,5-dihydro-lH-l,2,4-triazol-3-yl)propyl)- [l,l'-biphenyl]-3-yl)acetate (0.10 g, 0.25 mmol) in anhydrous CH3CN (4 mL) and Cs2C03 (0.25 g, 0.72 mmol) at rt was added 4-bromobenzyl bromide (0.076 g, 0.31 mmol). The resulting mixture was stirred at 65 C for 16 hrs. The mixture was diluted with EtOAc and a 50%> brine/50%) water solution. The organic extract was separated, washed once more with brine, filtered through a Na2S04/paper plug, and the filtrate concentrated in vacuo. The crude product thus obtained was used as is in the next step.

Reference： [1]Patent: WO2013/134562,2013,A1 .Location in patent: Paragraph 00154

2
[ 1256345-69-3 ]
[ 1454928-46-1 ]
[ 1454928-05-2 ]

Yield	Reaction Conditions	Operation in experiment
	With potassium fluoride; tetrakis(triphenylphosphine) palladium(0); In water; toluene; at 100℃; for 16h;Inert atmosphere;	Under a nitrogen atmosphere, 3-(3-(4-bromophenyl)propyl)-4-ethyl-lH-l,2,4-triazol-5(4H)- one (0.20 g, 0.65 mmol), Pd(PPh)4 (0.056 g, 0.065 mmol), KF (0.17 g, 2.84 mmol), (3-(2-ethoxy-2- oxoethyl)phenyl)boronic acid (0.296 g, 1.42 mmol), toluene (4 mL) and water (4 mL) were combined and the resulting mixture was stirred under nitrogen at 100 C for 16 hrs. The reaction mixture was then cooled to rt, diluted with EtOAc and washed with a 50% brine/50% water solution. The organic phase was separated, washed once more with brine, filtered through a Na2S04/paper plug, and the filtrate concentrated in vacuo. The residue was thus obtained was purified by column chromatography using a l%>-9%> gradient MeOH/DCM as eluent to afford 0.190 g of ethyl 2-(4'-(3-(4-ethyl-5-oxo-4,5-dihydro-lH-l,2,4-triazol-3- yl)propyl)-[l,l'-biphenyl]-3-yl)acetate (contaminated with unreacted starting material which coeluted). This was used as is in the next step.

Reference： [1]Patent: WO2013/134562,2013,A1 .Location in patent: Paragraph 00153

3
[ 1256345-69-3 ]
[ 1616372-71-4 ]
[ 1616372-83-8 ]

Yield	Reaction Conditions	Operation in experiment
	With tetrakis(triphenylphosphine) palladium(0); potassium carbonate; In 1,2-dimethoxyethane; water; at 85℃; for 3h;Inert atmosphere;	General procedure: Step 1: To a solution of 3-(3-(3-bromophenyl)propyl)-l -(4-(tert-butyl)benzyl)-4-ethyl-lH-l ,2,4- triazol-5(4H)-one (250 mg, 0.55 mmol) in a mixture of DME (5 mL) and water (2 mL) was added potassium carbonate (191 mg, 1.38 mmol) and <strong>[1256345-69-3]3-ethoxycarbonylmethylphenylboronic acid</strong> (191 mg, 0.66 mmol). After sparging the mixture with nitrogen, Pd(PPh3)4 (30 mg, cat.) was added and the reaction heated at 85 C for 3 hrs. The reaction as allowed to cool, partitioned between EtOAc and water, the organic phase extracted, dried(MgSO i), filtered and evaporated in vacuo. The residue was purified on silica gel eluting with a gradient of 0 to 60% EtOAc in hexanes to afford the ester of the title compound

Reference： [1]Patent: WO2014/99503,2014,A1 .Location in patent: Paragraph 00120

4
6-bromo-2,3-dimethoxyquinoxaline [ No CAS ]
[ 1256345-69-3 ]
2-(3-(2,3-dioxo-1,2,3,4-tetrahydroquinoxalin-6-yl)phenyl)acetic acid [ No CAS ]

Reference： [1]ACS Chemical Neuroscience,2017,vol. 8,p. 2477 - 2495

5
6-bromo-2,3-dimethoxyquinoxaline [ No CAS ]
[ 1256345-69-3 ]
ethyl 2-(3-(2,3-dimethoxyquinoxalin-6-yl)phenyl)acetate [ No CAS ]

Reference： [1]ACS Chemical Neuroscience,2017,vol. 8,p. 2477 - 2495

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P222	Do not allow contact with air.
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P230	Keep wetted
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P232	Protect from moisture.
P233	Keep container tightly closed.
P234	Keep only in original container.
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Response
Code	Phrase
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P304	IF INHALED:
P305	IF IN EYES:
P306	IF ON CLOTHING:
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P308	IF exposed or concerned:
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P313	Get medical advice/attention.
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P320
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P321
P322
P330	Rinse mouth.
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P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
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P361	Remove/Take off immediately all contaminated clothing.
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P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
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P378
P380	Evacuate area.
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P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
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P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
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P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
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Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
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H228	Flammable solid
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H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
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H290	May be corrosive to metals
Health hazards
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H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
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H351	Suspected of causing cancer
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H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

[ CAS No. 1256345-69-3 ] {[proInfo.proName]}

Quality Control of [ 1256345-69-3 ]

Related Doc. of [ 1256345-69-3 ]

Product Details of [ 1256345-69-3 ]

Calculated chemistry of [ 1256345-69-3 ]

Physicochemical Properties

Pharmacokinetics

Lipophilicity

Druglikeness

Water Solubility

Medicinal Chemistry

Safety of [ 1256345-69-3 ]

Application In Synthesis of [ 1256345-69-3 ]

[ 1256345-69-3 ] Synthesis Path-Downstream 1~5

Related Functional Groups of [ 1256345-69-3 ]

Organoboron

Aryls

Esters

Precautionary Statements-General

Prevention

Response

Storage

Disposal

Physical hazards

Health hazards

Environmental hazards

Inquiry

Related Functional Groups of
[ 1256345-69-3 ]