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Type | HazMat fee for 500 gram (Estimated) |
Excepted Quantity | USD 0.00 |
Limited Quantity | USD 15-60 |
Inaccessible (Haz class 6.1), Domestic | USD 80+ |
Inaccessible (Haz class 6.1), International | USD 150+ |
Accessible (Haz class 3, 4, 5 or 8), Domestic | USD 100+ |
Accessible (Haz class 3, 4, 5 or 8), International | USD 200+ |
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CAS No. : | 1256806-53-7 | MDL No. : | MFCD18256598 |
Formula : | C6H4FNO3 | Boiling Point : | - |
Linear Structure Formula : | - | InChI Key : | ZIUMHELXLSUNJQ-UHFFFAOYSA-N |
M.W : | 157.10 | Pubchem ID : | 58449071 |
Synonyms : |
|
Signal Word: | Danger | Class: | 6.1 |
Precautionary Statements: | P261-P264-P270-P271-P280-P302+P352-P304+P340-P310-P330-P361-P403+P233-P405-P501 | UN#: | 2811 |
Hazard Statements: | H301-H311-H331 | Packing Group: | Ⅲ |
GHS Pictogram: |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With lithium hydroxide monohydrate; In water; at 100℃; for 20h;Sealed tube; | To a sealable tube was added <strong>[745784-04-7]3,5-difluoropyridine-2-carboxylic acid</strong> (2.0 g, 12.57 mmol, Lancaster Synthesis Ltd.), lithium hydroxide hydrate (5.28 g, 126 mmol, Aldrich), and water (50 mL). The resulting mixture was stirred at 100 C for 20 h. Then the mixture was cooled to RT and TFA (5.0 mL, 67.3 mmol, Aldrich) was added to the A-1813-WO-PCT - 185 - mixture. The mixture was concentrated and dried in vacuo overnight to provide 12.6 g of a crude product mixture of 3-fluoro-5-hydroxypicolinic acid and 5-fluoro-3- hydroxypicolinic acid, as a white solid, used directly in the next step. MS (ESI, positive ion) m/z: 158.1 (M+H) observed for both isomers |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With lithium hydroxide; In tetrahydrofuran; water; at 100℃; for 18h; | Step 1: (0542) To <strong>[745784-04-7]3,5-difluoropyridine-2-carboxylic acid</strong> (3.0 g, 19 mmol) in THF (30 mL) in a glass tube reaction vessel was added 2N LiOH(aq). The reaction mixture was capped and warmed to 100 C. The reaction was stirred for 18 h and then cooled to room temperature. TFA (5 mL) was added and the reaction was concentrated in vacuo. The residue was purified by reverse phase chromatography [C18 (360 g) 0.1% formic acid/water for 20 minutes followed by 0-100% 0.1% formic acid/acetonitrile//0.1% formic acid/water] to provide the hydroxy pyridine (2.1 g) as a 1:1 mixture of starting material and product. The mixture was carried on directly. |
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