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Chemical Structure| 1257403-89-6 Chemical Structure| 1257403-89-6

Structure of 1257403-89-6

Chemical Structure| 1257403-89-6

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Product Details of [ 1257403-89-6 ]

CAS No. :1257403-89-6
Formula : C18H25NO5
M.W : 335.40
SMILES Code : O=C(OC(C)(C)C)N(CCC(C)=O)CC1=CC=C(C(OC)=O)C=C1
MDL No. :MFCD29924869

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Application In Synthesis of [ 1257403-89-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1257403-89-6 ]

[ 1257403-89-6 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 1257403-89-6 ]
  • [ 29097-00-5 ]
  • methyl 5-(N-Boc-N-benzyl-2-aminoethyl)-7-oxo-4,7-dihydropyrazolo[1,5-a]pyrimidin-3-carboxylate [ No CAS ]
YieldReaction ConditionsOperation in experiment
95% With acetic acid; at 80℃; for 24h; A mixture of 1 (1.413 g, 10 mmol), 2 (3.694 g, 10mmol), and AcOH (20 mL) was stirred at 80 C for 24 h.Volatile components were evaporated in vacuo and theresidue was purified by FC (EtOAc). Fractions containingthe product were combined and evaporated in vacuo togive 3. Yield: 4.059 g (95%) of pale beige solid; m.p. 161-165 C. 1H NMR (500 MHz, CDCl3): delta 1.30 (9H, s, t-Bu);2.95 (2H, t, J = 10.0 Hz, CH2); 3.54 (2H, t, J = 10.0 Hz,CH2); 3.86 (3H, s, OMe); 4.45 (2H, s, CH2Ph); 5.72 (1H, s,6-H); 7.29 (5H, m, Ph); 8.15 (1H, s, 2-H); 11.45 (1H, s, NH). 13C NMR (126 MHz, CDCl3): delta 27.6, 44.8, 48.3, 51.3,59.7, 78.7, 96.5, 99.4, 127.1, 127.4, 128.3, 138.3, 143.0,143.3, 154.4, 155.1, 162.0, 170.3. m/z (ESI) = 427 (MH+).HRMS-ESI (m/z): [MH+] calcd for C22H27N4O5, 427.1976;found, 427.1971. Anal. Calcd for C22H26N4O5: C 61.96, H6.15, N 13.14. Found: C 61.90, H 6.29, N 13.17. IR (ATR) nu3344, 2963, 1710, 1671, 1620, 1580, 1529, 1495, 1466, 1442,1414, 1365, 1323, 1303, 1259, 1247, 1185, 1167, 1145, 1124,1115, 1051, 1019, 963, 933, 887, 847, 791, 776, 729, 695,683, 657, 632 cm-1.
 

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• Acyl Group Substitution • Baeyer-Villiger Oxidation • Barbier Coupling Reaction • Baylis-Hillman Reaction • Bouveault-Blanc Reduction • Bucherer-Bergs Reaction • Buchwald-Hartwig C-N Bond and C-O Bond Formation Reactions • Catalytic Hydrogenation • Chan-Lam Coupling Reaction • Clemmensen Reduction • Complex Metal Hydride Reductions • Corey-Bakshi-Shibata (CBS) Reduction • Corey-Chaykovsky Reaction • Ester Cleavage • Fischer Indole Synthesis • Grignard Reaction • Henry Nitroaldol Reaction • Horner-Wadsworth-Emmons Reaction • Hydride Reductions • Lawesson's Reagent • Leuckart-Wallach Reaction • Mannich Reaction • McMurry Coupling • Meerwein-Ponndorf-Verley Reduction • Passerini Reaction • Paternò-Büchi Reaction • Petasis Reaction • Peterson Olefination • Pictet-Spengler Tetrahydroisoquinoline Synthesis • Preparation of Aldehydes and Ketones • Preparation of Amines • Prins Reaction • Reactions of Aldehydes and Ketones • Reactions of Amines • Reactions of Benzene and Substituted Benzenes • Reactions with Organometallic Reagents • Reformatsky Reaction • Robinson Annulation • Schlosser Modification of the Wittig Reaction • Schmidt Reaction • Specialized Acylation Reagents-Carbodiimides and Related Reagents • Specialized Acylation Reagents-Ketenes • Specialized Acylation Reagents-Vilsmeier Reagent • Stobbe Condensation • Tebbe Olefination • Ugi Reaction • Wittig Reaction • Wolff-Kishner Reduction

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