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Chemical Structure| 1258298-00-8 Chemical Structure| 1258298-00-8

Structure of 1258298-00-8

Chemical Structure| 1258298-00-8

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Product Details of [ 1258298-00-8 ]

CAS No. :1258298-00-8
Formula : C12H7BrCl2N2O
M.W : 346.01
SMILES Code : O=C(NC1=CC(Br)=NC=C1)C2=C(Cl)C=CC=C2Cl
MDL No. :MFCD22690823

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Application In Synthesis of [ 1258298-00-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1258298-00-8 ]

[ 1258298-00-8 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 876343-24-7 ]
  • [ 1258298-00-8 ]
  • [ 1258293-06-9 ]
YieldReaction ConditionsOperation in experiment
With palladium diacetate; caesium carbonate; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene; In 1,4-dioxane; at 150℃; for 0.333333h;Microwave irradiation; Inert atmosphere; Sealed tube; General procedure: A 20mL microwave tube was charged with pyrimidin-4-amine (220mg, 2.3mmol), N-(2-bromopyridin-4-yl)-2,6-dichloro benzamide (1.2g, 0.35mmol), Pd(OAc)2 (52mg, 0.23mmol), 4,5-bis(diphenylphosphino)-9,9-dimethylxantene (Xantphos, 0.27g, 0.46mmol), cesium carbonate (1.5g, 4.6mmol) and 1,4-dioxane (6mL). The mixture was degassed with nitrogen. The tube was sealed, and heated by microwave at 150°C for 20min. The mixture was purified by silica gel column chromatography (0?15percent DCM/MeOH) to afford the desired product (70mg, 8.4percent yield).
 

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