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Chemical Structure| 1260088-71-8 Chemical Structure| 1260088-71-8

Structure of 1260088-71-8

Chemical Structure| 1260088-71-8

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Product Details of [ 1260088-71-8 ]

CAS No. :1260088-71-8
Formula : C8H10N2O3
M.W : 182.18
SMILES Code : O=C1NC(C(C)(C)OC2)=C2C(N1)=O
MDL No. :MFCD20728676

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Application In Synthesis of [ 1260088-71-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1260088-71-8 ]

[ 1260088-71-8 ] Synthesis Path-Downstream   1~1

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  • [ 1260088-72-9 ]
YieldReaction ConditionsOperation in experiment
82% Step 3-Synthesis of p: A mixture of 7,7-dimethyl-5,7-dihydrofuro[3,4-d]pyrimidine-2,4(1H,3H)-dione (o) (2.55 g, 14.0 mmol), phosphoryl chloride (15 mL, 160 mmol) and 1,2-dichloroethane (80 mL) was heated at 80 C. for 20 h. The mixture was concentrated to a solid and partitioned between dichloromethane (250 mL) and saturated NaHCO3 (500 mL). The phases were separated and the aq. phase was extracted with dichloromethane (3×50 mL). The combined org. phases were dried (Na2SO4), filtered and concentrated to afford 2.53 g (82%) of 2,4-dichloro-7,7-dimethyl-5,7-dihydrofuro[3,4-d]pyrimidine (p) as a colorless solid: 1H NMR (400 MHz, CDCl3) delta 5.02 (s, 2H), 1.51 (s, 6H); LC-MS: m/z=+219 (M+H)+.
 

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