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Chemical Structure| 126052-34-4 Chemical Structure| 126052-34-4

Structure of 126052-34-4

Chemical Structure| 126052-34-4

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Product Details of [ 126052-34-4 ]

CAS No. :126052-34-4
Formula : C12H9N3
M.W : 195.22
SMILES Code : C12=NC(C3=CC=CC=C3)=CN1C=CN=C2
MDL No. :MFCD16659001

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Application In Synthesis of [ 126052-34-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 126052-34-4 ]

[ 126052-34-4 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 126052-34-4 ]
  • [ 3032-81-3 ]
  • 3-(3,5-dichlorophenyl)-2-phenylimidazo[1,2-a]pyrazine [ No CAS ]
YieldReaction ConditionsOperation in experiment
20% With palladium diacetate; potassium carbonate; tricyclohexylphosphine tetrafluoroborate; Trimethylacetic acid; In N,N-dimethyl acetamide; at 100℃; for 28h;Inert atmosphere; Sealed tube; General procedure: 2-Phenylimidazo[1,2-a]pyrazine 2 (1.0 mmol) was introducedinto a 10 mL vial with (hetero)arylhalide (2.0 mmol), palladiumacetate (0.04 mmol), tricyclohexylphosphine tetrafluoroborate(0.08 mmol), pivalic acid (0.6 mmol) and potassium carbonate(3.0 mmol) in N,N-dimethylacetamide (4 mL). The vial was purgedwith argon for 10 min and then sealed. The mixture was heated at100 C for 18e40 h and then it was cooled to room temperature.Water was added and the aqueous layer was extracted with ethylacetate (2 x 10 mL). The combined organic extracts were washedwith brine and water, dried over sodium sulfate, filtered, concentratedin vacuo and purified by silica gel column chromatography.Trituration with diisopropylic ether afforded the compounds 4aeg.
 

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