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Chemical Structure| 1260865-91-5
Chemical Structure| 1260865-91-5
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Product Details of [ 1260865-91-5 ]

CAS No. :1260865-91-5 MDL No. :MFCD31697651
Formula : C32H31BO2 Boiling Point : -
Linear Structure Formula :- InChI Key :XIPGCKFASRXQSN-UHFFFAOYSA-N
M.W : 458.40 Pubchem ID :70944631
Synonyms :

Calculated chemistry of [ 1260865-91-5 ]

Physicochemical Properties

Num. heavy atoms : 35
Num. arom. heavy atoms : 24
Fraction Csp3 : 0.19
Num. rotatable bonds : 5
Num. H-bond acceptors : 2.0
Num. H-bond donors : 0.0
Molar Refractivity : 147.26
TPSA : 18.46 Ų

Pharmacokinetics

GI absorption : Low
BBB permeant : No
P-gp substrate : Yes
CYP1A2 inhibitor : Yes
CYP2C19 inhibitor : No
CYP2C9 inhibitor : No
CYP2D6 inhibitor : Yes
CYP3A4 inhibitor : Yes
Log Kp (skin permeation) : -2.74 cm/s

Lipophilicity

Log Po/w (iLOGP) : 0.0
Log Po/w (XLOGP3) : 8.95
Log Po/w (WLOGP) : 6.99
Log Po/w (MLOGP) : 5.39
Log Po/w (SILICOS-IT) : 6.63
Consensus Log Po/w : 5.59

Druglikeness

Lipinski : 1.0
Ghose : None
Veber : 0.0
Egan : 1.0
Muegge : 1.0
Bioavailability Score : 0.55

Water Solubility

Log S (ESOL) : -8.5
Solubility : 0.00000146 mg/ml ; 0.0000000032 mol/l
Class : Poorly soluble
Log S (Ali) : -9.23
Solubility : 0.000000272 mg/ml ; 0.0000000006 mol/l
Class : Poorly soluble
Log S (SILICOS-IT) : -11.5
Solubility : 0.0000000014 mg/ml ; 0.0 mol/l
Class : Insoluble

Medicinal Chemistry

PAINS : 0.0 alert
Brenk : 2.0 alert
Leadlikeness : 2.0
Synthetic accessibility : 4.12

Safety of [ 1260865-91-5 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P261-P280-P301+P312-P302+P352-P305+P351+P338 UN#:N/A
Hazard Statements:H302-H315-H319-H335 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 1260865-91-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1260865-91-5 ]

[ 1260865-91-5 ] Synthesis Path-Downstream   1~85

  • 1
  • [ 61676-62-8 ]
  • [ 34699-28-0 ]
  • [ 1260865-91-5 ]
YieldReaction ConditionsOperation in experiment
64% M1 (10.29g, 25mmol) was dissolved in 120mL of freshly steamed tetrahydrofuran and placed in a low temperature reactor at -78 C for 10 min. After degassing three times, 16.6 mL of n-butyllithium (2.40 M, 40 mmol) was slowly added dropwise, and activated for 4 h. After that, 8 mL of isopropanol pinacol borate (40 mmol) was slowly added dropwise, and the mixture was stirred at room temperature for 48 h. The mixture was extracted with dichloromethane and concentrated to give a thickThe product was purified by column chromatography (yield: petroleum ether: methylene chloride = 3:1) to afford white solid (7.33 g, yield: 64%).
50% To a solution of compound 5 (3.22 g, 10 mmol) in anhydrous THF(15 mL), n-Butyllithium (1.6 mol/L, 7.5 mL, 12 mmol) was addeddropwise at -78 C. The reaction mixture was stirred for 0.5 h beforeisopropoxyboronic acid pinacol ester (2.5 mL, 12 mmol) was added inone portion. The mixture was warmed to room temperature and stirredfor 12 h. Then the mixture was poured into water while stirring. Theorganic phase was separated and the aqueous phase was extracted withdichloromethane (3 × 30 mL). The combined organic layers were driedover MgSO4 and evaporated to remove the solvents under vacuum. Theresidue was purified by column chromatography (petroleum ether/dichloromethane= 8/1) to provide 6 (1.6 g) as white solid in 50% yield.mp 203-205 C. 1H NMR (400 MHz, CDCl3) delta (ppm): 7.54-7.52(d,J = 8.04 Hz, 2H), 7.09-7.07(m, 8H), 7.04-6.98 (m, 9H). 13C NMR(100 MHz, CDCl3), delta (ppm): 148.26, 143.49, 143.44, 143.39, 141.75,140.73, 134.92, 132.82, 131.30, 130.98, 130.89, 127.71, 127.65,126.66, 126.53, 84.11, 22.99. Anal. Calcd for C32H31BO2: C, 83.84; H,6.82. Found: C, 83.06; H, 7.03.
  • 5
  • [ 1260865-91-5 ]
  • [ 1147081-43-3 ]
  • [ 1619222-83-1 ]
  • 6
  • [ 1260865-91-5 ]
  • [ 1619222-82-0 ]
  • [ 1619222-84-2 ]
  • 7
  • [ 34699-28-0 ]
  • [ 73183-34-3 ]
  • [ 1260865-91-5 ]
YieldReaction ConditionsOperation in experiment
83.6% With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; In 1,4-dioxane; at 80℃; for 12h;Inert atmosphere; 2.7.82 g (30 mmol) of bis(pinacolato)diboron,<strong>[34699-28-0]1-(4-bromophenyl)-1,2,2-triphenylethylene</strong> 10.5g(25mmol) and potassium acetate 7.35g (75mmol) are dissolved in 60mLIn a 100 mL three-necked flask of dioxane,0.54 g (0.75 mmol) of [1,1'-bis(diphenylphosphino)ferrocene]palladium dichloride was added under N2 protection.After stirring at room temperature for 10 min, the temperature was raised to 80 C and the reaction was continued for 12 h.The reaction mixture was then suction filtered with silica gel and the filtrate was collected.The dioxane is distilled off under reduced pressure to obtain a crude product.Using petroleum ether/ethyl acetate (v/v=30:1) as the eluent,The crude product was separated by silica gel column chromatography.9.6 g of pale yellow solid 1-(4-phenylboronic acid sterol ester)-1,2,2-tristyrene,The yield was 83.6%.
79% With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; In 1,4-dioxane; for 24h;Reflux; Inert atmosphere; A mixture of <strong>[34699-28-0]1-(4-bromophenyl)-1,2,2-triphenylethylene</strong> (4.0 g,9.8 mmol), bis(pinacolato)diboron (3.7 g, 14.6 mmol), CH3COOK (4.8 g, 48.8 mmol) and 1,1'-bis(diphenylphosphino)ferrocenepalladium dichloride (214 mg, 0.3 mmol) in 1,4-dioxane (100 mL) was refluxed for 24 h under nitrogen. After cooling to room temperature, the mixture was poured into water and extracted with CH2Cl2 (3 20 mL). The organic phase was collected and washed with water (3 x 20 mL) and dried with anhydrous Na2SO4. Thesolvent was removed under vacuum, and then the residue was purified by column chromatography with petroleum ether (PE)/CH2Cl2 (4:1) as an eluent to give compound 3 (3.6 g, yield: 79%) as a green solid. 1H NMR (400 MHz, CDCl3), delta: 7.54 (d, J = 8.0 Hz, 2H),7.09-7.01 (m, 17H), 1.32 (s, 12H).
76% With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; potassium acetate; In 1,4-dioxane; at 80℃; for 24h;Inert atmosphere; General procedure: In a 250 mL single-necked flask,Followed by addition of tetramethylene bromide 4 or 6 (1 eq)Diclofenac borate (1 eq or 2 eq),KOAc (4eq or 8eq),PdCl2 (dppf) 2 · CH2Cl2 (0.03 eq or 0.06 eq),Treated with 1,4-dioxane,Under nitrogen protection, heated to 80 reaction 24hCooled to room temperature, 1,4-dioxane was removed by distillation,And then extracted with CH2Cl2The solution was washed with water and dried over anhydrous magnesium sulfate.
  • 8
  • (S)-(-)-6,6'-dibromo-2,2'-dihexyloxy-[1,1'-binaphthalene] [ No CAS ]
  • [ 1260865-91-5 ]
  • (S)-(+)-2,2'-bis(hexyloxy)-6,6'-bis(4-(1,2,2-triphenylvinyl)phenyl)-1,1'-binaphthyl [ No CAS ]
  • 9
  • [ 1260865-91-5 ]
  • (R)-(+)-3,3'-dibromo-2,2'-bis(hexyloxy)-1,1'-binaphthyl [ No CAS ]
  • (R)-(+)-2,2'-bis(hexyloxy)-3,3'-bis(4-(1,2,2-triphenylvinyl)phenyl)-1,1'-binaphthyl [ No CAS ]
  • 10
  • [ 1260865-91-5 ]
  • (R)-(-)-6,6'-dibromo-2,2'-bis(hexyloxy)-1,1'-binaphthyl [ No CAS ]
  • (R)-(-)-2,2'-bis(hexyloxy)-6,6'-bis(4-(1,2,2-triphenylvinyl)phenyl)-1,1'-binaphthyl [ No CAS ]
  • 11
  • [ 1260865-91-5 ]
  • [ 4316-58-9 ]
  • N,N-bis(4-bromophenyl)-4'-(1,2,2-triphenylvinyl)[1,1'-biphenyl]-4-amine [ No CAS ]
  • 12
  • [ 1260865-91-5 ]
  • [ 22901-00-4 ]
  • C39H27NS [ No CAS ]
  • 13
  • [ 1260865-91-5 ]
  • [ 19654-14-9 ]
  • C39H27NS [ No CAS ]
  • 14
  • [ 1260865-91-5 ]
  • [ 19654-19-4 ]
  • C39H27NS [ No CAS ]
  • 15
  • [ 1260865-91-5 ]
  • [ 83834-12-2 ]
  • C64H44O2S [ No CAS ]
YieldReaction ConditionsOperation in experiment
78% With tetrakis(triphenylphosphine) palladium(0); potassium carbonate; In tetrahydrofuran; water; for 24h;Reflux; Inert atmosphere; To a mixture of 3,7-dibromodibenzothiophene-S,S-dioxide (374 mg,1.0 mmol), <strong>[1260865-91-5]4,4,5,5-tetramethyl-2-(4-(1,2,2-triphenylvinyl)phenyl)-1,3,2-dioxaborolane</strong> (1.15 g, 2.5 mmol), THF (60.0 mL) and aq. 2.0 MK2CO3 solution (20.0 mL), Pd(PPh3)4 (58 mg) was added after degassing.The mixture was heated to refllux with vigorously stirring for 24 hunder an N2 flow protection. After cooling to RT, the mixture waspoured into water and extracted with DCM. The organic layer was driedover anhydrous MgSO4 and evaporated to remove the solvent. Theresulted crude product was purified by column chromatography on silicagel (hexane/DCM 25/1) to give TPE-FSO-TPE (684 mg) in a yieldof 78%. 1H NMR (400 MHz, CDCl3) (ppm): 7.98 (s, 2H), 7.80 (s, 4H),7.38 (d, J 8.3 Hz, 4H), 7.17-7.09 (m, 22H), 7.09-7.01 (m, 12H). 13CNMR (CDCl3, 100 MHz) (ppm): 144.2, 143.4, 143.3, 143.1, 141.7,140.0, 138.5, 13 6.4, 132.1, 131.3, 129.9, 127.8, 127.6, 126.7, 126.6,126.5, 126.1, 121.7, 120.4. Anal. Calcd. for C64H44O2S: C, 87.64; H,5.06; S, 3.66; Found: C, 87.68; H, 5.08; S, 3.69. HRMS (ESI): calcd forC64H44O2S: 876.3062, found 876.3069.
  • 16
  • [ 15155-41-6 ]
  • [ 1260865-91-5 ]
  • 4-bromo-7-(4-(1,2,2-triphenylvinyl)phenyl)benzo[c][1,2,5]thiadiazole [ No CAS ]
  • 17
  • [ 1260865-91-5 ]
  • 10-(4-bromophenyl)-9-phenyl-9H-pyreno[4,5-d]imidazole [ No CAS ]
  • 9-phenyl-10-(4'-(1,2,2-triphenylvinyl)-[1,1'-biphenyl]-4-yl)-9H-pyreno[4,5-d]imidazole [ No CAS ]
  • 18
  • [ 1260865-91-5 ]
  • [ 1192270-02-2 ]
  • C74H78B2N4 [ No CAS ]
  • 19
  • [ 1260865-91-5 ]
  • C36H40Br2 [ No CAS ]
  • C88H78 [ No CAS ]
YieldReaction ConditionsOperation in experiment
84% With tetrakis(triphenylphosphine) palladium(0); potassium carbonate; In tetrahydrofuran; water; for 24h;Inert atmosphere; Schlenk technique; Reflux; A mixture of compound 1 (350mg, 0.56mmol), 4-Bpin-tetraphenylethene (769mg, 1.68mmol), Pd(PPh3)4 (40mg) and potassium carbonate (1.54g, 11.2mmol) in THF (15mL) and distilled water (5.6mL) was refluxed for 24h under nitrogen in a 100mL Schlenk tube. The mixture was extracted with dichloromethane for several times, the combined organic extracts were dried over anhydrous Na2SO4 and concentrated by rotary evaporation. The crude product was purified by column chromatography on silica gel using dichloromethane/petroleum ether as eluent to afford the product as light green powder in the yield of 84% (533mg). 1H NMR (300MHz, CDCl3) δ (ppm): 7.44 (s, 1H), 6.87-7.09 (m, 38H), 6.78-6.80 (m, 6H), 6.67 (d, J=7.8Hz, 4H), 6.56 (d, J=8.1Hz, 2H), 1.19 (s, 18H), 1.10 (s, 9H). 13C NMR (75MHz, CDCl3) δ (ppm): 148.0, 147.5, 143.8, 143.7, 143.6, 142.1, 141.3, 140.8, 140.6, 140.1, 140.0, 139.3, 137.5, 137.0, 131.6, 131.5, 131.3, 131.1, 131.0, 130.4, 129.3, 127.5, 126.3, 126.2, 123.3, 123.0, 34.1, 34.0, 31.3, 31.2. MS (MALDI-TOF), m/z: 1135.59 ([M+H]+, calcd for C88H78, 1134.61). Anal. Calcd for C88H78: C, 93.08; H, 6.92. Found: C, 92.87; H, 7.11.
  • 20
  • [ 1260865-91-5 ]
  • C37H39Br2N [ No CAS ]
  • C89H77N [ No CAS ]
YieldReaction ConditionsOperation in experiment
76% With tetrakis(triphenylphosphine) palladium(0); potassium carbonate; In tetrahydrofuran; water; for 24h;Inert atmosphere; Schlenk technique; Reflux; A mixture of compound 2 (216mg, 0.33mmol), 4-Bpin-tetraphenylethene (453mg, 0.99mmol), Pd(PPh3)4 (40mg) and potassium carbonate (910mg, 6.6mmol) in THF (10mL) and distilled water (3.3mL) was refluxed for 24h under nitrogen in a 100mL Schlenk tube. The mixture was extracted with dichloromethane for several times, the combined organic extracts were dried over anhydrous Na2SO4 and concentrated by rotary evaporation. The crude product was purified by column chromatography on silica gel using dichloromethane/petroleum ether as eluent to afford the product as a light green powder in the yield of 76% (291mg). 1H NMR (300MHz, CDCl3) δ (ppm): 6.78-7.08 (m, 44H), 6.62 (d, J=7.5Hz, 4H), 6.56 (d, J=7.8Hz, 2H), 1.18 (s, 18H), 1.07 (s, 9H). 13C NMR (75MHz, CDCl3) δ (ppm): 148.5, 148.3, 145.9, 144.3, 143.7, 143.5, 143.3, 142.7, 141.1, 140.9, 140.4, 136.6, 136.2, 135.6, 131.4, 131.3, 130.7, 130.6, 130.3, 129.5, 127.5, 127.4, 126.4, 126.3, 126.2, 123.4, 123.2, 117.4, 112.9, 34.1, 34.0, 31.2, 31.0. MS (MALDI-TOF), m/z: 1160.60 ([M+H]+, calcd for C89H77N, 1159.61). Anal. Calcd for C89H77N: C, 92.11; H, 6.69; N, 1.21. Found: C, 91.91; H, 6.92; N, 1.05.
  • 21
  • [ 1260865-91-5 ]
  • [ 6575-12-8 ]
  • C59H41N [ No CAS ]
  • 22
  • [ 1260865-91-5 ]
  • 2-bromo-6,7,8,9-tetrapropylpyrido[1,2-a]indole-10-carbaldehyde [ No CAS ]
  • 6,7,8,9-tetrapropyl-2-(4-(1,2,2-triphenylvinyl)phenyl)pyrido[1,2-a]indole-10-carbaldehyde [ No CAS ]
  • 23
  • [ 1260865-91-5 ]
  • [ 1399666-24-0 ]
  • 3-(4-methoxyphenyl)-2,5-bis(4-(1,2,2-triphenylvinyl)phenyl)thieno[3,2-b]thiophene [ No CAS ]
YieldReaction ConditionsOperation in experiment
78% With tetrakis(triphenylphosphine) palladium(0); potassium carbonate; In tetrahydrofuran; water; at 75℃; for 48h;Inert atmosphere; Schlenk technique; In a Schlenk tube, 2,5-dibromo-3-(4-methoxyphenyl)thieno[3,2- b]thiophene (0.5 g, 1.24 mmol), 4,4,5, 5-tetramethyl-2-(4-(l,2,2triphenylvinyl)phenyl)-l, 3,2- dioxaborolane ( 1.421 g, 3.1 mmol) and K2C03 (0.856 g, 6.2 mmol) was degassed under high vacuum. Degassed THF (18 mL) and water (2 mL) were added to the mixture and the solution was degassed with nitrogen. Tetrakis(triphenylphosphine)palladium(0) (72 mg, 0.062 mmol) was then added under nitrogen atmosphere. The mixture was stirred at 75 C for 2 days and allowed to cooled to room temperature. To the reaction mixture was added to water (150 mL) and extracted with dichloromethane (DCM) (3 x 50 mL). The collected organic layers was washed with water and brine twice, and then dried over NaS04. After removal of the solvent under reduced pressure, the crude product was purified by column chromatography over silica gel using a mixture of -hexane/dichloromethane (5: 1) as eluent. The product was obtained as a yellow solid in 78 % yield; 1H MR (500 MHz, CDC13) δ 7.42 (s, 1H), 7.37 (d, J = 8.28 Hz, 2H), 7.34 (d, J = 8.75 Hz, 2H), 7.11 (m, 34H), 6.94 (d, J = 8.32 Hz, 2H), 6.89 (d, J = 8.77 Hz, 2H), 3.87 (s, 3H) ppm; 13C MR (125 MHz, CDC13): δ 144.83, 143.68, 143.62, 143.58, 143.53, 143.36, 143.29, 143.06, 141.36, 140.92, 140.49, 140.30, 138.80, 137.02, 132.76, 132.63, 131.95, 131.45, 131.43, 131.40, 131.38, 131.34, 131.08, 128.42, 127.85, 127.76, 127.71, 127.69, 127.66, 127.60, 126.64, 126.57, 126.55, 126.50, 124.80, 115.44, 114.14, 55.24 ppm.
  • 24
  • [ 1260865-91-5 ]
  • Ν,N-bis(4-bromophenyl)-4-nitrobenzamide [ No CAS ]
  • N,N-bis(4'-(1,2,2-triphenylvinyl)-[1,1'-biphenyl]-4-yl)-4-nitrobenzamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
89% With tetrakis(triphenylphosphine) palladium(0); potassium carbonate; In tetrahydrofuran; at 70℃; for 24h;Inert atmosphere; A solution of 9.54 g (20 mmol) 4,4'-Bisbromophenyl Amine and 40 mmol (18.34 g) of tetraphenylborate were added to a 500 ml three-necked flask, 200 ml of tetrahydrofuran was added as a solvent, and 60 ml of a 2 M potassium carbonate solution was further added thereto. The mixture was stirred under argon, After the bath temperature was raised to 70 C, a catalytic amount of tetrakistriphenylphosphine palladium was added. After 24 hours of refluxing, the reaction mixture was spin-dried and purified by column chromatography. The product was collected to give a pale yellow solid, which was dried in vacuo at 60 C Overnight to give the product 17. 43 g, Yield 89%. The chemical formula for the intermediate C71H5003N2, molecular weight of 979. 17, the knot
  • 25
  • [ 3141-26-2 ]
  • [ 1260865-91-5 ]
  • 3,4-bis(4-(1,2,2-triphenylvinyl)phenyl)thiophene [ No CAS ]
  • 26
  • [ 3140-93-0 ]
  • [ 1260865-91-5 ]
  • 2,3-bis(4-(1,2,2-triphenylvinyl)phenyl)thiophene [ No CAS ]
  • 27
  • [ 3140-92-9 ]
  • [ 1260865-91-5 ]
  • 2,4-bis(4-(1,2,2-triphenylvinyl)phenyl)thiophene [ No CAS ]
  • 28
  • [ 3141-27-3 ]
  • [ 1260865-91-5 ]
  • 2,5-bis(4-(1,2,2-triphenylethenyl)phenyl)thiophene [ No CAS ]
  • 29
  • [ 1260865-91-5 ]
  • [ 880800-04-4 ]
  • C57H38BrN [ No CAS ]
YieldReaction ConditionsOperation in experiment
42% With tetrakis(triphenylphosphine) palladium(0); potassium carbonate; In tetrahydrofuran; for 24h;Reflux; Inert atmosphere; To a dry round bottom flask was added compound 2 (2.2 g,3.8 mmol), compound 3 (1.6 g, 3.5 mmol), tetrakis(-triphenylphosphine)palladium (120 mg, 0.1 mmol), potassiumcarbonate solution (2 M, 25 mL) and THF (80 mL). The mixture was refluxed for 24 h under nitrogen. After cooling to room temperature, the mixture was then poured into water and extracted withCH2Cl2 (3 x 20 mL). The organic phase was washed with water (3 x 20 mL) and dried with anhydrous Na2SO4. After Removing the solvent under vacuum, the residue was purified by column chromatography with PE/CH2Cl2 (4:1) as an eluent to get the compound 4 as a green solid (1.2 g, yield: 42%). 1H NMR (400 MHz, CDCl3), δ:7.82 (d, J = 8.4 Hz, 1H), 7.74 (t, J = 7.6 Hz, 2H), 7.68-7.55 (m, 5H), 7.49 (d, J = 8.0 Hz, 3H), 7.33 (d, J = 8.4 Hz, 2H), 7.21-7.05 (m, 16H),6.97 (t, J = 8.4 Hz, 3H), 6.62 (t, J = 7.6 Hz, 2H), 6.45 (d, J = 7.6 Hz 2H),6.39 (d, J = 7.6 Hz, 2H).
  • 30
  • [ 1260865-91-5 ]
  • C31H29BrN2O2 [ No CAS ]
  • C57H48N2O2 [ No CAS ]
YieldReaction ConditionsOperation in experiment
67% With tetrakis(triphenylphosphine) palladium(0); potassium carbonate; In tetrahydrofuran; at 65℃; for 24h;Inert atmosphere; General procedure: In a 250 mL single-necked flask,Add white solid 5 or 7 (1 eq) in turn,Light yellow solid 3 (1 eq or 2 eq),2M potassium carbonate solution (4eq or 8eq),Tetrakis (triphenylphosphine) palladium (0.03 eq or 0.06 eq),Dissolved in tetrahydrofuran,Under nitrogen protection, heated to 65 reaction 24hCooled to room temperature, tetrahydrofuran was removed by distillation,And then extracted with CH2Cl2 (3 x 20 mL). The extract was washed with water (3 x 20 mL)Dried over anhydrous magnesium sulfate.
  • 31
  • [ 1260865-91-5 ]
  • 4-(2-bromothieno[3,2-b]thiophen-3-yl)benzonitrile [ No CAS ]
  • 4-(2-(4-(1,2,2-triphenylvinyl)phenyl) thieno[3,2-b]-thiophen-3-yl)benzonitrile [ No CAS ]
  • 32
  • [ 1260865-91-5 ]
  • 4-(2,5-dibromothieno[3,2-b]thiophen-3-yl)benzonitrile [ No CAS ]
  • 4-(2,5-bis(4-(1,2,2-triphenylvinyl)phenyl)thieno-[3,2-b]thiophen-3-yl)benzonitrile [ No CAS ]
  • 33
  • [ 875314-58-2 ]
  • [ 1260865-91-5 ]
  • 4-(N,N-diphenylamino)phenyl-7-(1,2,2-triphenylvinyl)phenyl-(2,1,3)-benzoselenazole [ No CAS ]
YieldReaction ConditionsOperation in experiment
82% With tetrakis(triphenylphosphine) palladium(0); potassium carbonate; In tetrahydrofuran; for 24h;Inert atmosphere; Reflux; Pd(PPh3)4 (120 mg) was added to a mixture of 8 (1.05 g,1.77 mmol), 6 (959 mg, 2.1 mmol), THF (50.0 mL) and 2.0 M K2CO3solution (10.0 mL). The reaction mixture was degassed and heatedunder reflux with vigorously stirring for 24 h under N2 flow protection.After cooling to room temperature, the mixture was poured into waterand extracted with dichloromethane (3 × 30 mL). The combined organiclayers were collected, dried over anhydrous MgSO4, filtered andevaporated to remove the solvent. The resulted crude product waschromatographed on a silica gel column (petroleum ether/dichloromethane= 12/1) to give TPA-Se-TPE (1.09 g) in a yield of 82%.1H NMR (400 MHz, CDCl3) δ (ppm): 7.88-7.86 (d, J = 8.72 Hz, 2H),7.78-7.76 (d, J = 8.32 Hz, 2H), 7.69-7.64 (t, J = 9.28 Hz, 2H),7.37-7.33 (t, J = 7.92 Hz, 4H), 7.19-7.03 (m, 23H), 7.01-6.99 (d,J=7.96 Hz, 2H). 13C NMR (CDCl3, 100 MHz) δ (ppm): 147.51, 131.52,131.38, 130.21, 129.36, 128.62, 127.73, 127.65, 126.51, 124.89,123.27, 122.85, 122.81, 122.07. Anal. Calcd. for C50H35N3Se: C, 79.35;H, 4.66; N, 5.55; Found: C, 79.42; H, 4.73; N, 5.59. MALDI-TOF (m/z):calcd for TPA-Se-TPE: 757.2, found 757.212.
82% With tetrakis(triphenylphosphine) palladium(0); potassium carbonate; In tetrahydrofuran; water; for 24h;Inert atmosphere; Reflux; 1.05 g (1.77 mmol) of 4-bromo-7-(1,2,2-triphenylvinyl)phenyl-(2,1,3)-benzoselenadiazole,959 mg (2.1 mmol) of 4-(1,2,2-tristyryl)-phenylboronic acid pinacol ester and 10 mL of a 2.0 M aqueous potassium carbonate solution, and50 mL of THF was added to a 100 mL two-neck flask and 120 mg (0.105 mmol) of tetrakis(triphenylphosphine)palladium was added under nitrogen protection to heat it.Reflux, reaction 24h. After cooling to room temperature, the reaction solution was poured into deionized water and extracted three times with dichloromethane. The organic phases were combined and used.Washed. The organic phase was dried over anhydrous MgSO4 overnight and the volatile solvent was evaporated off on a rotary evaporator. Crude product separation and purification(Silicone is the stationary phase and petroleum ether/dichloromethane = 12/1 is used as eluent). Vacuum drying gave 1.09 g of an orange solid.82%.
  • 34
  • [ 63224-42-0 ]
  • [ 1260865-91-5 ]
  • 4,7-bis((1,2,2-triphenylvinyl)phenyl)-(2,1,3)-benzoselenadiazole [ No CAS ]
YieldReaction ConditionsOperation in experiment
67% With tetrakis(triphenylphosphine) palladium(0); potassium carbonate; In tetrahydrofuran; for 24h;Inert atmosphere; Reflux; Pd(PPh3)4 (143 mg) was added to a mixture of 3 (340 mg,1.0 mmol), 6 (1.14 g, 2.5 mmol), THF (50.0 mL) and 2.0 M K2CO3solution (10.0 mL). The mixture was degassed and heated under refluxwith vigorously stirring for 24 h under N2 flow protection. After cooledto room temperature, the mixture was poured into water and extractedwith dichloromethane (3 × 30 mL). The combined organic layers werecollected, dried over anhydrous MgSO4, filtered and evaporated to removethe solvent. The resulted crude product was chromatographed ona silica gel column (petroleum ether/dichloromethane = 10/1) to giveTPE-Se-TPE (565 mg) in a yield of 67%. 1H NMR (400 MHz, CDCl3) δ(ppm): 7.68-7.66 (d, J = 8.28 Hz, 4H), 7.56 (s, 2H), 7.19-7.16 (d,J = 8.32 Hz, 4H), 7.13-7.09 (m, 26H), 7.06-7.04 (m, 4H). 13C NMR(100 MHz, CDCl3) δ (ppm): 159.66, 143.80, 143.68, 143.62, 141.42,140.57, 135.97, 134.37, 131.51, 131.38, 128.65, 127.88, 127.73, 127.65, 126.59, 126.51. Anal. Calcd. for C58H40N2Se: C, 82.55; H, 4.78;N, 3.32; Found: C, 82.59; H, 7.75; N, 3.39. MALDI-TOF (m/z): calcd forTPE-Se-TPE: 844.236, found 844.239.
67% With tetrakis(triphenylphosphine) palladium(0); potassium carbonate; In tetrahydrofuran; water; for 24h;Inert atmosphere; Reflux; 340 mg (1.0 mmol) of 4,7-dibromo-(2,1,3)-benzoselenadiazole,1.145 g (2.5 mmol) 4-(1,2,2-tristyryl)-phenylboronic acid pinacol ester and 10 mL 2.0MAn aqueous solution of potassium carbonate and 50 mL of THF were added to a 100 mL three-necked bottle and after exhausting for 30 minutes,143 mg of Pd(PPh3)4 was added to the reaction system. Stir and stop at reflux for 24 hoursThe reaction was cooled to room temperature. The cooled reaction solution was poured into 40 mL of distilled water and extracted twice with DCM to obtain the organic layer.Dry over anhydrous MgSO4. The crude product was purified by column chromatography (petroleum ether: dichloromethane = 10:1) to give a yellow solid product.565 mg (yield: 67%).
  • 35
  • [ 1260865-91-5 ]
  • C28H16BrN3 [ No CAS ]
  • C54H35N3 [ No CAS ]
  • 36
  • [ 1260865-91-5 ]
  • C28H16BrN3 [ No CAS ]
  • [ 1619222-84-2 ]
  • 37
  • [ 1260865-91-5 ]
  • 4-(2-(2-bromophenyl)-1H-phenanthro[9,10-d]imidazol-1-yl)benzonitrile [ No CAS ]
  • C54H35N3 [ No CAS ]
  • 38
  • [ 1260865-91-5 ]
  • C39H26BrN3 [ No CAS ]
  • C65H45N3 [ No CAS ]
  • 39
  • [ 1260865-91-5 ]
  • C39H26IN3 [ No CAS ]
  • C65H45N3 [ No CAS ]
  • 40
  • [ 1260865-91-5 ]
  • [ 1295502-53-2 ]
  • 5,6-difluoro-4,7-bis(4-(1,2,2-triphenylvinyl)phenyl)benzo[c][1,2,5]thiadiazole [ No CAS ]
  • 41
  • [ 15155-41-6 ]
  • [ 1260865-91-5 ]
  • [ 1332644-19-5 ]
  • 42
  • [ 1260865-91-5 ]
  • [ 1347736-74-6 ]
  • 5-fluoro-4,7-bis(4-(1,2,2-triphenylvinyl)phenyl)benzo[c][1,2,5]thiadiazole [ No CAS ]
  • 43
  • [ 54286-63-4 ]
  • [ 1260865-91-5 ]
  • C58H40N2O [ No CAS ]
  • 44
  • [ 1260865-91-5 ]
  • 4,4'-(3,4-dinitrothiophene-2,5-diyl)bis(N,N-bis(4-bromophenyl)aniline) [ No CAS ]
  • N,N'-((3,4-dinitrothiophene-2,5-diyl)bis(4,1-phenylene))bis(4'-(1,2,2-triphenylvinyl)-N-(4'-(1,2,2-triphenylvinyl)-[1,1'-biphenyl]-4-yl)-[1,1'-biphenyl]-4-amine) [ No CAS ]
YieldReaction ConditionsOperation in experiment
78% With tetrakis(triphenylphosphine) palladium(0); potassium carbonate; In tetrahydrofuran; water; for 24h;Inert atmosphere; Reflux; Darkness; 4, 4'- (3, 4-Dinitrothiophene-2, 5-diyl) bis (N, N-bis (4-bromophenyl) aniline) (2.44 g, 2.5 mmol) , 4, 4, 5, 5-tetramethyl-2- (4- (1, 2, 2-triphenylvinyl) phenyl) -1, 3, 2-dioxaborolane (5.50 g, 12 mmol) , Pd (PPh3)4(230 mg, 0.2 mmol) , and K2CO3(4.14 g, 30 mmol) were added into a 250 mL two-necked round-bottom flask. The flask was vacuumed and purged with dry nitrogen three times. Then anhydrous tetrahydrofuran (60 mL) and water (15 mL) were added, and the mixture was heated to reflux and stirred under nitrogen atmosphere for 24 hours in the absence of light. After cooling to room temperature, water was added, and the mixture was extracted with dichloromethane three times. The organic phase was combined, and dried with MgSO4. After the removal of the solvent under reduced pressure, the residue was purified by silica gel column chromatography using dichloromethane/hexane (v/v 1: 4) as the eluent to result in N, N'- ( (3, 4-dinitrothiophene-2, 5-diyl) bis (4, 1-phenylene) ) bis (4'- (1, 2, 2-triphenylvinyl) -N- (4'- (1, 2, 2 -triphenylvinyl) - [1, 1'-biphenyl] -4-yl) - [1, 1'-biphenyl] -4-amine) as a red solid (78%yield) .
  • 45
  • [ 1260865-91-5 ]
  • [ 76186-72-6 ]
  • [ 1378502-40-9 ]
YieldReaction ConditionsOperation in experiment
80% With tetrakis(triphenylphosphine) palladium(0); potassium carbonate; In tetrahydrofuran; for 24h;Inert atmosphere; Reflux; Darkness; 4, 4, 5, 5-Tetramethyl-2- (4- (1, 2, 2-triphenylvinyl) phenyl) -1, 3, 2-dioxaborolane (2.29 g, 5 mmol) , 4, 7-dibromo-5, 6-dinitrobenzo [c] [1, 2, 5] thiadiazole (0.77 g, 2 mmol) , and Pd (PPh3)4(60 mg, 0.05 mmol) were added into a 100 mL two-necked round-bottom flask. The flask was vacuumed and purged with dry nitrogen three times. Then anhydrous tetrahydrofuran (40 mL) was added, and the mixture was heated to reflux and stirred for 24 hours in the absence of light. After cooling to room temperature, water was added, and the mixture was extracted with dichloromethane three times. The organic phase was combined and dried with MgSO4. After removal of the solvent under reduced pressure, the residue was purified by column chromatography on silica gel using dichloromethane/hexane (v/v 1: 4) as the eluent to result in 5, 6-dinitro-4, 7-bis (4- (1, 2, 2-triphenylvinyl) phenyl) benzo [c] [1, 2, 5] thiadiazole as a red solid (80%yield) .
  • 46
  • [ 90224-73-0 ]
  • [ 1260865-91-5 ]
  • 5-(4-(1,2,2-triphenylethenyl)phenyl)-N-methylphthalimide [ No CAS ]
YieldReaction ConditionsOperation in experiment
92.6% With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium hydrogencarbonate; In water; toluene; at 80℃; for 3h; 4. In a 100 mL three-necked flask,1-(4-phenylboronic acid sterol ester)-1,2,2-triphenylethylene 4.79 g (20.9 mmol),4-bromo-N-methylphthalimide 2.64g (11mmol) and NaHCO3 1.76g (20.9mmol) were dissolved in a mixed solvent of 60mL toluene/water (V/V=3:1), then [1,1'-bis(diphenylphosphino)ferrocene]palladium dichloride 0.23 g (0.33 mmol) was added under N2 protection.After stirring at room temperature for 10 min, the temperature was raised to 80 C and the reaction was continued for 3 h.The solvent is distilled off to obtain a crude product.Using petroleum ether/ethyl acetate (100:1 to 4:1, v/v) as the eluent,The crude product was roughly separated by silica gel column chromatography and then recrystallized from 50 mL of methanol.5.01 g of white solid 5-(4-(1,2,2-triphenylethenyl)phenyl)-N-methylphthalimide,The yield was 92.6% and this product was used directly in the next step.
  • 47
  • 2,7-dibromotriphenylene [ No CAS ]
  • [ 1260865-91-5 ]
  • C70H48 [ No CAS ]
YieldReaction ConditionsOperation in experiment
70% With tetrakis(triphenylphosphine) palladium(0); sodium hydroxide; In tetrahydrofuran; water;Reflux; 2,7-dibromotriphenylene (7.7 g, 20 mmol) was dissolved in THF and then 4,4,5,5-tetramethyl-2- (4- (1,2,2-triphenylvinyl) dioxaborolane (18.3g, 40mmol), Pd (PPh3) 4 (0.7g, 0.6mmol), NaOH (2.4g, 60mmol) and water were added and then stirred and refluxed.After completion of the reaction, the reaction mixture was extracted with ether and water. The organic layer was dried over MgSO 4 and concentrated. The resulting organic material was subjected to silicagel column and recrystallization to obtain 12 g (yield: 70%) of final product P-38.
  • 48
  • [ 1260865-91-5 ]
  • 1,4-dibromotriphenylene [ No CAS ]
  • C70H48 [ No CAS ]
YieldReaction ConditionsOperation in experiment
72% With tetrakis(triphenylphosphine) palladium(0); sodium hydroxide; In tetrahydrofuran; water;Reflux; 1,4-dibromotriphenylene (7.7 g, 20 mmol) was dissolved in THF, <strong>[1260865-91-5]4,4,5,5-tetramethyl-2-(4-(1,2,2-triphenylvinyl)phenyl)-1,3,2-dioxaborolane</strong> (18.3 g, 40 mmol)Pd(PPh3)4 (0.7 g, 0.6 mmol), NaOH (2.4 g, 60 mmol) and water are added, and the mixture is refluxed with stirring. After completion of the reaction, the reaction mixture was extracted with ether and water. The organic layer was dried over MgSO 4 and concentrated. The resulting organic material was subjected to silicagel column and recrystallization to obtain 12.8 g (yield: 72%) of final product P-92.
  • 49
  • [ 1260865-91-5 ]
  • 7,10-dibromo-2,3-diphenyltriphenylene [ No CAS ]
  • C82H56 [ No CAS ]
YieldReaction ConditionsOperation in experiment
68% With tetrakis(triphenylphosphine) palladium(0); sodium hydroxide; In tetrahydrofuran; water;Reflux; After dissolving 7,10-dibromo-2,3-diphenyltriphenylene (10.8 g, 20 mmol) in THF, 4,4,5,5-tetramethyl-2-(4-(1,2,2-triphenylvinyl)1,3,2-dioxaborolane (18.3 g, 40 mmol), Pd(PPh3)4 (0.7 g, 0.6 mmol), NaOH (2.4 g, 60 mmol) and water were added and stirred and refluxed. After completion of the reaction, the reaction mixture was extracted with ether and water. The organic layer was dried over MgSO4 and concentrated. The resultant organic material was subjected to silicagel column and recrystallization to obtain 14.2 g (yield: 68%) of final product P-81.
  • 50
  • [ 1260865-91-5 ]
  • [ 1575-37-7 ]
  • C32H26N2 [ No CAS ]
YieldReaction ConditionsOperation in experiment
76% With potassium carbonate; In water; toluene; at 80℃; for 24h;Inert atmosphere; The 4-bromo-benzene-1,2-diamine (2mmol, 376mg), 4,4,5,5 -tetramethyl-2-(4-triphenylvinyl-phenyl)- [1-3]dioxaborolane (1) (2.4mmol, 1.1g), Pd(PPh3)4 (0.2mmol, 230mg) and K2CO3 (6mmol, 829mg) were dissolved in a mixture of toluene (20mL)/ethanol (8mL)/H2O (1mL). The mixture was stirred at 80C for 24h under nitrogen atmosphere. Then, the reaction mixture was allowed to cool to room temperature, and vapored to dryness. The residue was subjected to column chromatography on silica (petroleum ether/CH2Cl2 1:1 in vol.) to yield the desired product 2 (shown in Scheme 1) as brown yellow solid. Yield: 76%. 1H NMR (600MHz, CDCl3, δ[ppm]): 7.27 (s, 1H), 7.13-7.04 (m, 14H), 7.04-7.00 (m, 4H), 6.94-6.90 (m, 2H), 6.72 (d, J=7.8Hz, 1H)·13C NMR (150MHz, CDCl3, δ[ppm]): 143.9, 141.8, 140.8, 134.9, 134.3, 131.7, 131.5, 131.5, 127.8, 127.7, 126.5, 126.4, 125.6, 118.9, 117.0, 115.3. MALDI-TOF-MS [m/z]: 438.4372 [M]+.
  • 51
  • [ 1260865-91-5 ]
  • 3,3'-(9H-fluorene-9,9-diyl)bis(9-(4-bromophenyl)-9H-carbazole) [ No CAS ]
  • 3,3'-(9H-fluorene-9,9-diyl)bis(9-(4'-(1,2,2-triphenylvinyl)-[1,1'-biphenyl]-4-yl)-9H-carbazole) [ No CAS ]
  • 52
  • [ 1260865-91-5 ]
  • 6,6'-(9H-fluorene-9,9-diyl)bis(3-bromo-9-phenyl-9H-carbazole) [ No CAS ]
  • 6,6'-(9H-fluorene-9,9-diyl)bis(9-phenyl-3-(4-(1,2,2-triphenylvinyl)phenyl)-9H-carbazole) [ No CAS ]
  • 53
  • [ 523-27-3 ]
  • [ 1260865-91-5 ]
  • C40H27Br [ No CAS ]
YieldReaction ConditionsOperation in experiment
46% With tetrakis(triphenylphosphine) palladium(0); potassium carbonate; In water; toluene; for 24h;Reflux; Inert atmosphere; 250mL round-bottomed flask, 9,10-dibromo-anthracene (3.33g, 10mmol), M2 ( 4.6g, 10mmol),tetrakis(triphenylphosphine)palladium (240mg, 0.21mmol), potassium carbonate (13.8 g, 100 mmol) was dissolved in 100mL toluene and 50mL aqueous solution under nitrogen atmosphere at reflux for 90 C for 24 hours.Liquid separation was extracted with dichloromethane, and concentrated to give the crude product purified by column chromatography (petroleum ether: dichloromethane = 1: 1) to give a white solid (2.70 g of, yield: 46%).
  • 54
  • [ 1260865-91-5 ]
  • 2-chloro-4-(dibenzo[b,d]furan-3-yl)-6-phenyl-1,3,5-triazine [ No CAS ]
  • 2-(dibenzo[b,d] furan-3-yl)-4-phenyl-6-(4-(1,2,2-triphenylvinyl)phenyl)-1,3,5-triazine [ No CAS ]
YieldReaction ConditionsOperation in experiment
87% With tetrakis(triphenylphosphine) palladium(0); potassium carbonate; In tetrahydrofuran; water; at 75℃; for 66h;Inert atmosphere; Reagents and reaction conditions: 2-chloro-4-(dibenzo [b,d] furan-3-yl)-6-phenyl- 1,3,5- triazine (1.0 eq.), 4,4,5 ,5-tetramethyl-2- (4-( 1 ,2,2-triphenylvinyl)phenyl)- 1,3 ,2-dioxaborolane (1.2 eq.), tetrakistriphenylphosphine palladium (0) (Pd(PPh3)4) (0.02 eq.), potassium carbonate (2.0 eq.). 66h at 75C (l8OmL, THF/H20 2/1).When the reaction was completed according TLC, it was cooled down to 5C. Precipitate was filtered, dissolved in dichloromethane and washed with water. Organic phase was filtered over a pad of florisil and then concentrated. With the addition of hexane, some precipitate was formed, filtered and further recrystallized in toluene. 16.Og (87% yield). MS (ESI): 654 (M+H).
  • 55
  • [ 1260865-91-5 ]
  • [ 1247124-77-1 ]
  • 2,4-di(naphthalen-2-yl)-6-(4-(1,2,2-triphenylvinyl)phenyl)-1,3,5-triazine [ No CAS ]
YieldReaction ConditionsOperation in experiment
90% With tetrakis(triphenylphosphine) palladium(0); potassium carbonate; In tetrahydrofuran; water; at 75℃; for 64h;Inert atmosphere; Reagents and reaction conditions: 2-chloro-4,6-di(naphthalen-2-yl)- 1,3 ,5-triazine (1.0 eq.), 4,4,5 ,5-tetramethyl-2- (4- (1 ,2,2-triphenylvinyl)phenyl)- 1,3 ,2-dioxaborolane (1.2 eq.), tetrakistriphenyiphosphine palladium (0) (Pd(PPh3)4) (0.02 eq.), potassium carbonate (2.0 eq.). 64h at 75C (l8OmL, THF/H20 2/1).When the reaction was completed according TLC, it was cooled down to 5C. Precipitate was filtered, dissolved in chloroform and washed with water. Organic phase was filtered over a pad of florisil and then concentrated. With the addition of hexane, some precipitate was formed, filtered and further triturated in toluene. 16.3g (90% yield). MS (ESI): 664 (M+H).
  • 56
  • [ 1700-02-3 ]
  • [ 1260865-91-5 ]
  • 2-phenyl-4,6-bis(4-(1,2,2-triphenylvinyl)phenyl)-1,3,5-triazine [ No CAS ]
YieldReaction ConditionsOperation in experiment
49% With tetrakis(triphenylphosphine) palladium(0); potassium carbonate; In 1,4-dioxane; water; at 90℃; for 17h;Inert atmosphere; Reagents and reaction conditions: 2,4-dichloro-6-phenyl-1,3,5-triazine (1.0 eq.), 4,4,5,5-tetramethyl-2-(4- (1 ,2,2-triphenylvinyl)phenyl)- 1,3 ,2-dioxaborolane (2.2 eq.),tetrakistriphenylphosphine palladium (0) (Pd(PPh3)4) (0.04 eq.), potassium carbonate (4.0 eq.). 17h at 90C (126 mL, dioxane/H20 2/1).When the reaction was completed according TLC, reaction was cooled down to room temperature and solvent was evaporated. Crude compound was dissolved in chloroform and washed with water. Organic phase was filtered over a pad of silicagel and solvent was then evaporated. Crude solid was recrystallized first in toluene, and then in chlorobenzene. 5.5g (49% yield). MS (ESI): 818 (M+H).
  • 57
  • [ 1260865-91-5 ]
  • 2,4-dichloro-6-(dibenzo[b,d]furan-3-yl)-1,3,5-triazine [ No CAS ]
  • 2-(dibenzo[b,d]furan-3-yl)-4,6-bis(4-(1,2,2-triphenylvinyl)phenyl)-1,3,5-triazine [ No CAS ]
YieldReaction ConditionsOperation in experiment
36% With tetrakis(triphenylphosphine) palladium(0); potassium carbonate; In 1,4-dioxane; water; at 90℃; for 17h;Inert atmosphere; Reagents and reaction conditions: 2,4-dichloro-6-(dibenzo [b,d] furan-3-yl)- 1,3 ,5-triazine (1.0 eq.), 4,4,5 ,5-tetramethyl-2- (4-( 1 ,2,2-triphenylvinyl)phenyl)- 1,3 ,2-dioxaborolane (2.2 eq.), tetrakistriphenyiphosphine palladium (0) (Pd(PPh3)4) (0.04 eq.), potassium carbonate (4.0 eq.). 17h at 90C (1 l2mL, dioxane/H20 2/1).When the reaction was completed according TLC, precipitate was filtered and washed with water. Then it was dissolved in dichloromethane and filtered over a pad of florisil, then concentrated to induce precipitation. Upon addition of cyclohexane, precipitation took place. Solid was filtered and recrystallized in toluene. 4. ig (36% yield). MS (ESI): 908 (M+H).
  • 58
  • [ 1260865-91-5 ]
  • [ 23674-20-6 ]
  • C46H32 [ No CAS ]
  • 59
  • [ 1260865-91-5 ]
  • [ 97094-37-6 ]
  • 4,4″-bis(1,2,2-triphenylvinyl)-[1,1':3′,1″-terphenyl]-4′,6′-dicarbaldehyde [ No CAS ]
YieldReaction ConditionsOperation in experiment
73% With tetrakis(triphenylphosphine) palladium(0); tetra(n-butyl)ammonium hydrogensulfate; sodium carbonate; In water; toluene; at 80℃; for 48h;Inert atmosphere; Compound 1 (2.70 g, 9.25 mmol), 2 (12.72 g, 27.75 mmol), Na2CO3(13.50 g, 127.37 mmol), tetrabutylammonium hydrogen sulfate(TBAHS) (1.00 g, 4.12 mmol) and Pd(PPh3)4 (100 mg, 0.087 mmol)were added into toluene/H2O (360 mL, v/v=5/4). The mixture wasrefluxed with stirring for 48 h under nitrogen atmosphere. After thereaction was complete, the mixture was cooled to room temperature,and then the organic layer was separated, the aqueous layer extractedwith CH2Cl2 (2×100 mL), the combined organic layer dried over anhydrousNa2SO4. Upon evaporating off the solvent, the crude productwas subjected to purification by column chromatography (silica gel;petroleum ether/CH2Cl2, v/v=1/1), affording a light yellow solid(5.40 g). Yield 73%. Mp: 346-348 C. 1H NMR (400 MHz, CDCl3) δ 9.95(s, 2H), 8.61 (s, 1H), 7.50 (s, 1H), 7.18-7.13 (m, 26H), 7.10-7.06 (m,12H) (Fig. S19); 13C NMR (100 MHz, CDCl3) δ 191.10, 149.34, 144.80,143.37, 143.29, 143.21, 142.19, 139.87, 134.41, 132.92, 132.79,131.62, 131.33, 131.26, 129.28, 128.10, 127.86, 127.82, 127.72,126.87, 126.73 (Fig. S20). IR (KBr, cm-1): 623, 700, 754, 823, 857,987, 1030, 1075, 1125, 1300, 1442, 1470, 1492, 1595, 1697. HRMS(MALDI-TOF) m/z: [M+H]+ Calcd for C60H43O2 795.3263; Found795.5409 (Fig. S21). Anal. Calcd (%) for C60H42O2: C 90.65, H 5.33;Found: C 90.69, H 5.39.
  • 60
  • [ 1260865-91-5 ]
  • [ 92874-17-4 ]
  • 2–butyl–6–(4–(1,2,2–triphenylvinyl)phenyl)–1H–benzo[de]isoquinoline–1,3(2H)–dione [ No CAS ]
YieldReaction ConditionsOperation in experiment
56% With sodium carbonate; triphenylphosphine; In tetrahydrofuran; water; at 70℃; for 8h;Inert atmosphere; General procedure: 5-Bromo-2-butyl-1H-benzo[de]isoquinoline-1,3(2H)-dione 7 or 6-bromo-2-butyl-1H-benzo[de]isoquinoline-1,3(2H)-dione 8 (0.2 g, 0.60 mmol), 1-(4-bromophenyl)-1,2,2-triphenylethylene (0.29 g, 0.63 mmol), Pd(PPh3)4 (0.028 g,4 mol%), and 2M sodium carbonate solution (4 mL) were dissolved inTHF (20 mL). The reaction mixture was left for 8 h under a nitrogenatmosphere at 70 C. After completion of the reaction, the reactionmixture was cooled to room temperature and poured into water(50 mL), followed by extraction with diethyl ether (50 mL) for twotimes. Subsequently, the organic layer was separated and washed withsaturated brine solution. After drying it over sodium sulfate (Na2SO4), itwas concentrated under vacuum. The resulting residue was purified by column chromatography on silica gel with hexane/chloroform (3:7, v/v) as the eluent.
  • 61
  • [ 1260865-91-5 ]
  • 5–bromo–2–butyl–1H–benzo[de]isoquinoline–1,3(2H)–dione [ No CAS ]
  • 2–butyl–5–(4–(1,2,2–triphenylvinyl)phenyl)–1H–benzo[de]isoquinoline–1,3(2H)–dione [ No CAS ]
YieldReaction ConditionsOperation in experiment
49% With tetrakis(triphenylphosphine) palladium(0); sodium carbonate; In tetrahydrofuran; water; at 70℃; for 8h;Inert atmosphere; General procedure: 5-Bromo-2-butyl-1H-benzo[de]isoquinoline-1,3(2H)-dione 7 or 6-bromo-2-butyl-1H-benzo[de]isoquinoline-1,3(2H)-dione 8 (0.2 g, 0.60 mmol), 1-(4-bromophenyl)-1,2,2-triphenylethylene (0.29 g, 0.63 mmol), Pd(PPh3)4 (0.028 g,4 mol%), and 2M sodium carbonate solution (4 mL) were dissolved inTHF (20 mL). The reaction mixture was left for 8 h under a nitrogenatmosphere at 70 C. After completion of the reaction, the reactionmixture was cooled to room temperature and poured into water(50 mL), followed by extraction with diethyl ether (50 mL) for twotimes. Subsequently, the organic layer was separated and washed withsaturated brine solution. After drying it over sodium sulfate (Na2SO4), itwas concentrated under vacuum. The resulting residue was purified by column chromatography on silica gel with hexane/chloroform (3:7, v/v) as the eluent. 2-Butyl-5-(4-(1,2,2-triphenylvinyl)phenyl)-1H-benzo[de]isoquinoline-1,3(2H)-dione, 1: NTPE 1 was obtained in 49% yield(0.172 g).1H NMR (CDCl3, 600 MHz) δ 8.813 (1H, d, J=1.651 Hz,aromatic), 8.557 (1H, dd, J1-2=1.1 Hz, J1-3=7.153 Hz, aromatic),8.320 (1H, d, J=1.926 Hz, aromatic), 8.202 (1H, dd, J1-2=1.1 Hz,J1-3=8.528 Hz, aromatic), 7.742 (1H, t, J=8.253 Hz, aromatic),7.526 (2H, d, J=8.528 Hz, aromatic), 7.188 (2H, d, J=8.528 Hz,aromatic), 7.169-7.050 (15H, m, aromatic), 4.203 (2H, t, J=7.428 Hz,-NCH2), 1.756-1.705 (2H, m, -CH2), 1.491-1.429 (2H, m, -CH2),0.987 (3H, t, J=7.153 Hz, -CH3).13C NMR (CDCl3, 150 MHz) δ164.24, 164.21, 144.03, 143.56, 143.50, 141.7, 140.14, 139.62,136.92, 133.90, 132.19, 132.10, 131.39, 131.34, 131.31, 130.82,130.77, 130.56, 127.86, 127.79, 127.68, 127.25, 127.18, 126.70,126.63, 126.59, 126.56, 123.11, 122.67, 40.28, 30.24, 20.39, 13.86.HRMS (ESI-TOF): m/Z calculated for C42H34NO2 584.2584 [M+H]+,measured 584.2578 [M+H]+.
  • 62
  • [ 1260865-91-5 ]
  • [ 1422738-41-7 ]
  • 7-tert-butyl-1,3,5,9-tetrakis(4-(1,2,2-triphenylvinyl)phenyl)pyrene [ No CAS ]
YieldReaction ConditionsOperation in experiment
78% With tetrakis(triphenylphosphine) palladium(0); potassium carbonate; In ethanol; water; toluene; at 20 - 90℃; for 24h;Inert atmosphere; 7-tert-butyl-1,3,6,8-tetrabromoindole (0.15 g, 0.26 mmol) under nitrogen.<strong>[1260865-91-5]1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)-1,2,2-triphenylethylene</strong>(0.95 g, 2.07 mmol) and potassium carbonate (0.72 g, 5.18 mmol) in a solution of degassed toluene/ethanol/water mixture (8:2:2 = v/v/v) (32/8/8 mL) Stir at room temperature,The catalyst Pd(PPh3)4 (0.12 g, 0.10 mmol) was added after vacuuming three times with nitrogen.The mixture was heated to reflux at 90 C and stirred for 24 h. The reaction system was then cooled to room temperature.Extract with dichloromethane, wash with saturated sodium chloride solution, dry over anhydrous magnesium sulfate and filtered. The solvent was evaporated to dryness After vacuum drying, purification by vacuum sublimation gave a yellow solid, which was converted to 7-tert-butyl-1,3,6,8-tetrabromoindole.The yield of the final product was 78% (0.32 g).
  • 63
  • [ 940274-68-0 ]
  • [ 1260865-91-5 ]
  • C86H68N4O4 [ No CAS ]
YieldReaction ConditionsOperation in experiment
85% With tetrakis(triphenylphosphine) palladium(0); In ethanol; water; toluene; at 90℃; for 24h;Schlenk technique; Inert atmosphere; Alkaline conditions; PDIN-2Br (1.56 g, 2.18 mmol), compound 5a (2.50 g, 5.46 mmol),Sodium carbonate (2.31 g, 21.80 mmol) and Pd(PPh3) 4 (catalytic amount) were added to a Schlenk (250 mL) bottle. Under a nitrogen atmosphere, toluene (40 mL), ethanol (20 mL) and water (10 mL) were added separately. the temperature was then raised to 90 C and refluxed for 24 h. After cooling to room temperature, concentrate under reduced pressure the reaction solution. diluted with methylene chloride, water was added, and dichloromethane was evaporated. Purified by silica gel column with dichloromethane: triethylamine (400:1) as eluent. the compound P4P-N was obtained.It was a purple solid with a yield of 85%.
  • 64
  • [ 1260865-91-5 ]
  • C10H5Br2N3 [ No CAS ]
  • C62H43N3 [ No CAS ]
YieldReaction ConditionsOperation in experiment
58% With palladium diacetate; caesium carbonate; XPhos; In ethanol; water; toluene; at 110℃; for 6h;Inert atmosphere; Target Compound J-5 (4.81 g, yield 58%) was obtained in the same manner as in Synthesis Example 1 except that A-5 (3.26 g, 10.0 mmol) was used instead of A-1, and <strong>[1260865-91-5]4,4,5,5-tetramethyl-2-(4-(1,2,2-triphenylvinyl)phenyl)-1,3,2-dioxaborolane</strong> (9.16 g, 20.0 mmol) was used instead of 2,4-diphenyl-6-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)-1,3,5-triazine. (0250) [LCMS]: 830
  • 65
  • [ 1260865-91-5 ]
  • 7-tert-butyl-1,3-diphenyl-5,9-dibromopyrene [ No CAS ]
  • 7-tert-butyl-1,3-diphenyl-5,9-bis(4-(1,2,2-triphenylvinyl)phenyl)pyrene [ No CAS ]
YieldReaction ConditionsOperation in experiment
58% With tetrakis(triphenylphosphine) palladium(0); potassium carbonate; In ethanol; water; toluene; at 90℃; for 24h;Inert atmosphere; A solution of 2 (1.04 g, 1.83 mmol), <strong>[1260865-91-5]4,4,5,5-tetramethyl-2-(4-(1,2,2-triphenylvinyl)phenyl)-1,3,2-dioxaborolane</strong> (2.50 g, 5.50 mmol), Pd(PPh3)4 (0.32 g,0.28 mmol), and potassium carbonate (3.80 g, 27.50 mmol) in degassedtoluene/ethanol/water mixture (8:2:2: v/v/v 120 mL) was heated toreflux for 24 h under nitrogen. The precipitate was washed with water,acetone and collected by filtration. After drying under vacuum, thecrude products were purified by sublimation under vacuum gave Py(5,9)BTPE (1.14 g, 58%) as a yellow solid. Mp. 290 C. νmax (KBr)/cm-1: ν=3025 (=C-H), 1590 (C]C). 1H NMR (400 MHz, CDCl3,50 C): δ=8.17 (s, 2H), 8.08 (s, 2H), 7.92 (s, 1H), 7.66 (d, J=8 Hz,4H), 7.51 (t, J=16 Hz, 6H), 7.41 (t, J=16 Hz, 2H), 7.34 (d, J=8 Hz,4H), 7.19-7.09 (m, 32H), 1.47 (s, 9H). MS (MALDI-TOF): m/z calcd. forC84H62 1070.49; Found 1070.58 [M+H]+. Anal. Calcd for C84H62: C,94.17; H, 5.83%. Found: C, 94.15; H, 5.84%.
  • 66
  • [ 1260865-91-5 ]
  • 4-bromo-7-(2-nitrophenyl)benzo[c][1,2,5]thiadiazole [ No CAS ]
  • 4-(2-nitrophenyl)-7-(4-(1,2,2-triphenylvinyl)phenyl)benzo[c][1,2,5]thiadiazole [ No CAS ]
YieldReaction ConditionsOperation in experiment
60% With tetrakis(triphenylphosphine) palladium(0); potassium carbonate; In tetrahydrofuran; water; at 80℃; for 24h;Inert atmosphere; 1 mmol compound 1, 1.1 mmol <strong>[1260865-91-5]4,4,5,5-tetramethyl-2-(4-(1,2,2-triphenylvinyl)phenyl)-1,3,2-dioxaborolane</strong>, 0.05 mmol Pd(PPh3)4 and 2mmol K2CO3 were added into a mixture of THF (70 mL)/H2O (10 mL).The mixture was stirred at 80 C for 24 h under protection of N2 atmosphere.After cooling to room temperature, the solvent was removed under vacuum. The residue was purified by silica gel flash columnchromatography. Yield: 60%. 1H NMR (600 MHz, DMSO) 8.21 (d, J 8.4 Hz, 1H), 7.98 (d, J 7.3 Hz, 1H), 7.92 (d, J 7.5 Hz, 1H), 7.90 (s,1H), 7.89-7.86 (m, 2H), 7.78 (dd, J 17.4, 8.1 Hz, 2H), 7.23-7.19 (m,3H), 7.18 (s, 2H), 7.16 (d, J 9.2 Hz, 4H), 7.14-7.10 (m, 2H), 7.08 (dd,J 12.6, 7.6 Hz, 4H), 7.02 (d, J 7.4 Hz, 2H). 13C NMR (150 MHz,DMSO) 154.13, 152.92, 149.52, 144.00, 143.64, 143.60, 143.57,141.84, 140.76, 134.99, 134.01, 133.19, 133.12, 132.22, 131.28,131.11, 131.05, 131.01, 130.52, 130.26, 129.26, 128.88, 128.41,128.32, 128.27, 128.16, 127.12, 127.01, 126.96, 124.96, 40.89, 40.75,40.62, 40.48, 40.34, 40.20, 40.06. Elemental analysis: anal. calcd for C38H25N3O2S: C, 77.66; H, 4.29; N, 7.15, S, 5.46; Found: C, 77.23; H,4.46; N, 7.31, S, 5.18. Found: [M] 587.1638; ‘molecular formulaC38H25N3O2S0 requires [M] 587.1667.
  • 67
  • [ 1260865-91-5 ]
  • 4-bromo-7-(3-nitrophenyl)benzo[c][1,2,5]thiadiazole [ No CAS ]
  • 4-(3-nitrophenyl)-7-(4-(1,2,2-triphenylvinyl)phenyl)benzo[c][1,2,5]thiadiazole [ No CAS ]
YieldReaction ConditionsOperation in experiment
73% With tetrakis(triphenylphosphine) palladium(0); potassium carbonate; In tetrahydrofuran; water; at 80℃; for 24h;Inert atmosphere; General procedure: 1 mmol compound 1, 1.1 mmol <strong>[1260865-91-5]4,4,5,5-tetramethyl-2-(4-(1,2,2-triphenylvinyl)phenyl)-1,3,2-dioxaborolane</strong>, 0.05 mmol Pd(PPh3)4 and 2mmol K2CO3 were added into a mixture of THF (70 mL)/H2O (10 mL).The mixture was stirred at 80 C for 24 h under protection of N2 atmosphere.After cooling to room temperature, the solvent was removed under vacuum. The residue was purified by silica gel flash columnchromatography. Yield: 60%.
  • 68
  • [ 1260865-91-5 ]
  • 4-bromo-7-(4-nitrophenyl)benzo[c][1,2,5]thiadiazole [ No CAS ]
  • 4-(4-nitrophenyl)-7-(4-(1,2,2-triphenylvinyl)phenyl)benzo[c][1,2,5]thiadiazole [ No CAS ]
YieldReaction ConditionsOperation in experiment
70% With tetrakis(triphenylphosphine) palladium(0); potassium carbonate; In tetrahydrofuran; water; at 80℃; for 24h;Inert atmosphere; General procedure: 1 mmol compound 1, 1.1 mmol <strong>[1260865-91-5]4,4,5,5-tetramethyl-2-(4-(1,2,2-triphenylvinyl)phenyl)-1,3,2-dioxaborolane</strong>, 0.05 mmol Pd(PPh3)4 and 2mmol K2CO3 were added into a mixture of THF (70 mL)/H2O (10 mL).The mixture was stirred at 80 C for 24 h under protection of N2 atmosphere.After cooling to room temperature, the solvent was removed under vacuum. The residue was purified by silica gel flash columnchromatography. Yield: 60%.
  • 69
  • [ 1260865-91-5 ]
  • C39H26BrN3 [ No CAS ]
  • N-phenyl-N-(4-(1-phenyl-1H-phenanthro[9,10-d]imidazol-2-yl)phenyl)-4'-(1,2,2-triphenylvinyl)-[1,1'-biphenyl]-4-amine [ No CAS ]
  • 70
  • [ 1260865-91-5 ]
  • C20H14BrNO2 [ No CAS ]
  • C46H33NO2 [ No CAS ]
  • 71
  • [ 19063-55-9 ]
  • [ 1260865-91-5 ]
  • 6-(4-(1,2,2-triphenylvinyl)phenyl)-2H-chromen-2-one [ No CAS ]
  • 72
  • [ 19063-56-0 ]
  • [ 1260865-91-5 ]
  • 7-(4-(1,2,2-triphenylvinyl)phenyl)-2H-chromen-2-one [ No CAS ]
  • 73
  • [ 1260865-91-5 ]
  • [ 83834-12-2 ]
  • C38H25BrO2S [ No CAS ]
YieldReaction ConditionsOperation in experiment
58% With tetrakis(triphenylphosphine) palladium(0); potassium carbonate; In tetrahydrofuran; water; for 16h;Reflux; Inert atmosphere; <strong>[1260865-91-5]4,4,5,5-tetramethyl-2-(4-(1,2,2-triphenylvinyl)phenyl)-1,3,2-dioxaborolane</strong>(1.38 g, 3.0 mmol), 3,7-dibromodibenzothiophene-S,S-dioxide(1.12 g, 3.0 mmol), Pd(PPh3)4 (69 mg), THF (70.0 mL) and aq. 2.0 MK2CO3 solution (20.0 mL) were added in a 150 mL flask. The mixturewas heated to refllux for 16 h under argon atmosphere. After cooling toRT, the mixture was poured into brine and extracted twice with DCM.The combined organic layers were dried over MgSO4 and the solventwas removed. The crude product was purified with column chromatographyon silica gel (hexane/DCM 20/1) to yield 1.01 g (58%) of 3as yellow solid. 1H NMR (400 MHz, CDCl3) (ppm): 1H NMR (400 MHz,CDCl3) 7.95 (d, J 11.0 Hz, 2H), 7.83-7.72 (m, 3H), 7.65 (d, J 8.2Hz, 1H), 7.37 (d, J 8.3 Hz, 2H), 7.19-7.09 (m, 11H), 7.09-7.00 (m, 6H).
  • 74
  • [ 1260865-91-5 ]
  • 4,9-bis(5-bromo-3-hexylthiophen-2-yl)naphtho[2,3-c][1,2,5]thiadiazole [ No CAS ]
  • 4,9-bis(3-hexyl-5-(4-(1,2,2-triphenylvinyl)phenyl)thiophen-2-yl)naphtho[2,3-c][1,2,5]thiadiazole [ No CAS ]
  • 75
  • [ 1260865-91-5 ]
  • 4,9-bis(5-bromo-4-hexylthiophen-2-yl)naphtho[2,3-c][1,2,5]thiadiazole [ No CAS ]
  • 4,9-bis(34-hexyl-5-(4-(1,2,2-triphenylvinyl)phenyl)thiophen-2-yl)naphtho[2,3-c][1,2,5]thiadiazole [ No CAS ]
  • 76
  • [ 1260865-91-5 ]
  • C22H14Br2O2S3 [ No CAS ]
  • 3,5-bis-(4-methoxyphenyl)-2,6-bis-(4-triphenylvinylphenyl)dithieno[3,2-b;2',3'-d]thiophene [ No CAS ]
  • 77
  • [ 1260865-91-5 ]
  • C12H5Br3S2 [ No CAS ]
  • 3-(4'-triphenylvinylbiphenyl-4-yl)-2,5-bis-(4-triphenylvinylphenyl)thieno[3,2-b]thiophene [ No CAS ]
  • 78
  • [ 1260865-91-5 ]
  • (E)-3-(5-bromothiophen-2-yl)-3-(5-(pyridin-4-yl)thiophen-2-yl)acrylonitrile [ No CAS ]
  • C42H28N2S2 [ No CAS ]
YieldReaction ConditionsOperation in experiment
45% (3) 90mg (E)-3-(5-bromothiophene-2-)-2-(5-(pyridine-4-)thiophen-2-)acrylonitrile (0.24mmol, compound E1), 142.1mgTetrastyrene pinacol borate(0.31 mmol, compound F5), and 254.2 mg of sodium carbonate (2.4 mmol) were added to a mixed solvent of 20 mL of toluene, 2 mL of ethanol and 1 mL of water, and the mixture was stirred and replaced under argon protection at room temperature for 30 min. Add 6mg of tetrakistriphenylphosphonium palladium (0.005mmol), stir for 5min at room temperature under the protection of argon, and then heat to reflux for 12h. After the reaction solution was cooled to room temperature, 20 mL of dichloromethane was added for extraction three times, the organic phases were combined, washed with saturated brine three times, and dried over anhydrous sodium sulfate. The organic solvent was distilled off under reduced pressure, and the crude product was separated and purified by silica gel column chromatography. The eluent was dichloromethane: ethyl acetate = 10:1 to obtain 67.5 mg
  • 79
  • [ 1260865-91-5 ]
  • [ 89972-76-9 ]
  • [ 1332830-69-9 ]
  • 80
  • [ 1260865-91-5 ]
  • [ 214779-03-0 ]
  • C120H84 [ No CAS ]
  • 81
  • [ 1260865-91-5 ]
  • C28H29BrNO2(1+)*I(1-) [ No CAS ]
  • C54H48NO2(1+) [ No CAS ]
YieldReaction ConditionsOperation in experiment
Ca. 24% With tetrakis(triphenylphosphine) palladium(0); potassium carbonate; In tetrahydrofuran; water; for 24h;Inert atmosphere; Reflux; Synthesis of probeThe synthesis method is shown in Figure 1.Specific steps: Add Intermediate 1 (30 mg, 0.048 mmol) into the reaction flask, 4-(1,2,2-Tristyryl)-phenylboronic acid pinacol ester (40 mg, 0.087 mmol), K2CO3 (0.338 g, 2.45 mmol), vacuum-nitrogen replacement 3 times, adding under nitrogen protection, 4ml THF, Pd(PPh3)4 (5 mg, 0.004 mmol), 1ml H2O were added, heated to reflux, 24 hours later, dichloromethane was added for extraction 4 times, the organic phases were combined and concentrated to obtain a crude product. The crude product was separated and purified by a flash chromatography column (dichloromethane: methanol = 20/1, v/v) to obtain a blue solid compound (yield: about 24%). Characterized by nuclear magnetic and mass spectrometry.
  • 82
  • [ 1260865-91-5 ]
  • 7-bromo-10-propyl-10H-phenothiazine-3-carbonitrile [ No CAS ]
  • C42H32N2S [ No CAS ]
  • 83
  • [ 1260865-91-5 ]
  • 3-(7-bromo-10-propyl-10H-phenothiazin-3-yl)-2-phenylacrylonitrile [ No CAS ]
  • C50H38N2S [ No CAS ]
  • 84
  • [ 1260865-91-5 ]
  • 3-(benzothiazol-2-yl)-5-bromo-2-hydroxybenzaldehyde [ No CAS ]
  • C40H27NO2S [ No CAS ]
YieldReaction ConditionsOperation in experiment
33.6% With tetrakis(triphenylphosphine) palladium(0); potassium carbonate; In water; N,N-dimethyl-formamide; at 75℃; for 12h;Inert atmosphere; Weigh compound HBTBrQ (108.8mg, 0.33mmol) and4,4,5,5-tetramethyl-2-(4-(1,2,2-triphenylvinyl)phenyl)-1,3,2-dioxaborane (149.8mg, 0.33 mmol) dissolved in 5mL DMF,Stir thoroughly at room temperature, and then add 600 μL of an aqueous solution containing 250 mg of K2CO3 to the reaction system, and add 33 mg of catalyst Pd(PPh3)4.The reaction system was fully refluxed for 12 hours at 75C under the protection of nitrogen.After the TLC panel monitors the completion of the reaction, the solvent is distilled off under reduced pressure,The product HBTTPEQ was separated by silica gel column chromatography. The yield was 33.6%.
  • 85
  • [ 1260865-91-5 ]
  • [ 1422738-41-7 ]
  • C124H90 [ No CAS ]
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