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Chemical Structure| 1262803-64-4 Chemical Structure| 1262803-64-4

Structure of 1262803-64-4

Chemical Structure| 1262803-64-4

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Product Details of [ 1262803-64-4 ]

CAS No. :1262803-64-4
Formula : C7H8N2O3
M.W : 168.15
SMILES Code : O=C(C1=NC=C(CO)N=C1)OC
MDL No. :MFCD22572544

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Application In Synthesis of [ 1262803-64-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1262803-64-4 ]

[ 1262803-64-4 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 1262803-64-4 ]
  • [ 193966-70-0 ]
YieldReaction ConditionsOperation in experiment
56.5% With N-Bromosuccinimide; triphenylphosphine; In tetrahydrofuran; at 20℃; for 1.5h; A solution of methyl 5-(hydroxymethyl)pyrazine-2-carboxylate (1.65 g, 9.81 mmol) in tetrahydrofuran (THF, 49.1 mL) was treated with triphenylphosphine (3.09 g, 11.78 mmol), followed by N-bromosuccinimide (NBS, 2.096 g, 11.78 mmol) at room temperature (RT). After stirring for 90 min, the reaction was complete. After quenching with water and extraction with EtOAc (3×50 mL), the combined organic extracts were dried over Na2SO4, filtered and concentrated. The crude product was purified on a 40 silica column, eluted with EtOAc:Hexane (0-100% gradient). The desired fractions were concentrated and yield compound 2 (1.28 g, 5.54 mmol, 56.5% yield). LCMS ESI: calculated for C7H7BrN2O2=230.0, 232.0 (M+H+), found 230.9, 232.9 (M+H+).
 

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