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Chemical Structure| 127350-92-9 Chemical Structure| 127350-92-9

Structure of 127350-92-9

Chemical Structure| 127350-92-9

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Product Details of [ 127350-92-9 ]

CAS No. :127350-92-9
Formula : C6H6FN3O2
M.W : 171.13
SMILES Code : NNC1=CC=C([N+]([O-])=O)C=C1F
MDL No. :MFCD00498970

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* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 127350-92-9 ]

[ 127350-92-9 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 80370-42-9 ]
  • [ 127350-92-9 ]
  • [ 219664-16-1 ]
YieldReaction ConditionsOperation in experiment
49% With sodium acetate; In ethanol; at 20 - 80℃; for 3.5h; To a solution of 2-fluoro-4-nitro-phenyl)-hydrazine (17.0 grams, 99.4 mmol) in ethanol (350 mL) were added ethyl 2-formyl-3-oxo-propionate' (18.6 grams, 129.2 mmol) and sodium acetate (8.2 grams, 99.4 mmol) and stirred at room temperature for half an hour and then at 80 0C for 3 hours. Ethanol was removed in rotavapor and the residue obtained was dissolved in ethyl <n="52"/>acetate. Ethyl acetate portion was washed successively with water (100 mL x 2), saturated sodium bicarbonate solution (50 mL) and brine (100 mL). Organic layer was then dried over anhydrous sodium sulfate and concentrated to obtain a brown solid. Triturated with diethyl ether and filtered to get 13.6 grams of free flowing solid.Yield: 49percent,MS (m/z): 280 (M++ 1),1H NMR (300 MHz, CDCl3): delta 8.64 (d, J= 2.5 Hz, IH), 8.18-8.30 (m, 4H), 4.36 (q, J= 7.1 Hz,2H), 1.39 (t, J= 7.1 Hz, 3H).
 

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