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CAS No. :127406-55-7 MDL No. :MFCD01631910
Formula : C12H9NO Boiling Point : -
Linear Structure Formula :- InChI Key :NXZUVHZZIZHEOP-UHFFFAOYSA-N
M.W : 183.21 Pubchem ID :3693046
Synonyms :

Safety of [ 127406-55-7 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P261-P305+P351+P338 UN#:N/A
Hazard Statements:H315-H319-H335 Packing Group:N/A
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Application In Synthesis of [ 127406-55-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 127406-55-7 ]
  • Downstream synthetic route of [ 127406-55-7 ]

[ 127406-55-7 ] Synthesis Path-Upstream   1~15

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Reference: [1] Bioorganic and Medicinal Chemistry Letters, 2005, vol. 15, # 3, p. 631 - 634
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YieldReaction ConditionsOperation in experiment
87% With potassium phosphate tribasic heptahydrate; C18H24N3O2Pd In ethanol; water at 60℃; for 4 h; General procedure: The reaction vessel was charged with heteroaryl bromides (1.0mmol), arylboronic acid (1.2mmol), K3PO4·7H2O (1.5mmol), and the catalyst 1 (0.5molpercent) in EtOH/H2O (1:2, v/v 3mL). The reaction mixture was heated at 60°C in air and the progress of the reaction was monitored by TLC. At the end of the reaction, the reaction mixture was diluted with water (20mL) and then extracted with EtOAc (2×20mL). The combined organic layers were washed with brine (10mL) and then dried over anhydrous Na2SO4. After removal of the solvent, the crude product was purified by flash chromatography over silica gel using ethyl acetate/hexane as an eluent to afford the pure product.
25% With sodium carbonate In ethanol; water; toluene for 8 h; Heating / reflux Tetrakis (TRIPHENYLPHOSPHINE) palladium (0. 65 g, 0. 56 MMOL), 4-FORMYLPHENYLBORIC acid (2. 81 g, 18. 7 MMOL), 2M aqueous sodium carbonate (18. 7 ml, 37. 4 mmol) and ethanol were added to the nitrogen-saturated solution of 3-bromopyridine (2. 66 g, 16. 8 mmol) in toluene and refluxed under nitrogen for 8 hrs. Water was added to the solution and extracted with ethyl acetate, washed with water and brine and dried. Solvents were removed under reduced pressure and the residue was purified by silica gel column chromatography (eluent ; hexane/ethyl acetate = 1/1. 5) to give 4- (3-PYRIDYL) benzaldehyde (0. 78 g, 25percent).
Reference: [1] Patent: US6548494, 2003, B1,
[2] Polyhedron, 2016, vol. 120, p. 150 - 153
[3] ACS Catalysis, 2013, vol. 3, # 12, p. 2776 - 2789
[4] Organic Letters, 2004, vol. 6, # 19, p. 3337 - 3340
[5] Patent: WO2004/85408, 2004, A1, . Location in patent: Page 265
[6] Journal of Medicinal Chemistry, 2013, vol. 56, # 20, p. 8049 - 8065
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YieldReaction ConditionsOperation in experiment
93% With copper(l) iodide; C37H51ClFeNPPd; cesium fluoride In N,N-dimethyl-formamide at 80℃; for 12 h; Inert atmosphere General procedure: 4.3.10
4-(Pyridin-3-yl)benzaldehyde (3ja)
White solid, mp 50-51 °C; 1H NMR (400 MHz, CDCl3): δ=10.09 (s, 1H), 8.90 (d, J=1.76 Hz, 1HAryl halide (0.5 mmol), base (1 mmol), CuI (20 mol percent), alkylstannylpyridine(0.75 mmol), and catalyst (1 mol percent) were dissolvedin DMF (2 mL) in a 10 mL vial and heated at a specific temperatureunder N2 for 12 h. After the reaction was complete, and thenquenched with water. The mixture was diluted with ethyl acetate(10 mL), filtered through a pad of Celite, and followed by extractionwith ethyl acetate for three times. The combined organic layer wasdried over anhydrous Na2SO4, filtered, and evaporated under reducedpressure. The residual was purified by flash chromatographyon silica gel (ethyl acetate/hexane) to give the desired product.), 8.68-8.66 (m, 1H), 8.00 (d, J=8.24 Hz, 2H), 7.93 (d, J=7.88 Hz, 1H), 7.76 (d, J=8.20 Hz, 2H), 7.41-7.44 (m, 1H); 13C NMR (100 MHz, CDCl3): δ=123.8, 127.8, 127.8, 130.5, 130.5, 134.6, 135.3, 135.8, 143.8, 148.4, 149.6, 191.8; HRMS-ESI (m/z): [M+H]+ calcd for C12H10NO+: 184.0757, found: 184.0758.
Reference: [1] Tetrahedron, 2013, vol. 69, # 2, p. 902 - 909
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YieldReaction ConditionsOperation in experiment
84%
Stage #1: With iodine; magnesium In tetrahydrofuran at 30 - 35℃; for 2 h;
Stage #2: at 50℃; for 2.5 h;
Anhydrous zinc chloride (6.8 g, 0.05.0 moles) and then 3-bromopyridine (26.4 g, 0.167 mol) are added with agitation under an inert atmosphere, to a solution constituted by toluene (78 g) and tetrahydrofuran (66 g). [00117] Palladium tetrakistriphenylphosphine (0.102 g, 0.089 mmol) and then, over a period of 2 hours, a solution of the Grignard reagent of 4-bromobenzaldehyde dimethyl acetal (169.3 g of solution, equal to 0.197 mol), prepared analogously to Example 1, are added to the suspension maintained at 50° C. with agitation and under an inert atmosphere. [00118] The reaction mixture is maintained at 50° C. for 30 minutes and then cooled to 25° C. [00119] 4-(3'-pyridyl)benzaldehyde (25.6 g, 0.14 mol) is obtained with a yield of 84percent in moles relative to the 3-bromopyridine added, turnover of the catalyst (Pd): 1576. [00120] IR: 1701.6 cm-1 (aldehyde C-O stretching) [00121] m.p.: 52°-53° C. [00122] 1H-NMR (300 MHz, CDCl3): ppm 10.1 (1H, s); 8.9 (1H, d, J=2.2 Hz); 8.7 (1H, dd, J=1.6 Hz, J=4.9 Hz); 8.02 (2H, part A of an AB system, J=8.2 Hz); 7.97 (1H, ddd, J=2.2 Hz, J=7.9 Hz, J=1.6 Hz); 7.78 (2H, part B of an AB system, J=8.2 Hz); 7.45 (1H, dd, J=4.9 Hz, J=7.9 Hz)
3%
Stage #1: With iodine; magnesium In tetrahydrofuran at 30 - 35℃; for 2 h;
Stage #2: at 50℃; for 2.5 h;
Example 24 was repeated but in the absence of zinc chloride. The yield in moles of 4-(3'-pyridyl)benzaldehyde relative to the 3-bromopyridine added was 3percent, turnover of the catalyst (Pd) 56.
Reference: [1] Patent: US6765097, 2004, B1, . Location in patent: Page column 14
[2] Patent: US6765097, 2004, B1, . Location in patent: Page column 14
[3] Patent: US5849911, 1998, A,
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Reference: [1] European Journal of Organic Chemistry, 2009, # 13, p. 2051 - 2054
[2] Journal of Medicinal Chemistry, 2005, vol. 48, # 1, p. 224 - 239
[3] Dalton Transactions, 2007, # 35, p. 3952 - 3958
[4] European Journal of Medicinal Chemistry, 2016, vol. 115, p. 453 - 462
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YieldReaction ConditionsOperation in experiment
45% With copper(I) oxide; tetrakis(triphenylphosphine) palladium(0); 1,10-Phenanthroline In N,N-dimethyl acetamide at 60 - 180℃; for 4 h; Inert atmosphere; Glovebox; Microwave irradiation General procedure: In an argon-filled glovebox, a 10 mL microwave vial was charged with Pd(PPh3)4 (14.35 mg,0.0125 mmol), Cu2O (21.3 mg, 0.15 mmol), 1,10-phenanthroline (8.95 mg,0.05 mmol), the potassium pyridylcarboxylate (0.50 mmol), aryl bromide(0.75 mmol) and anhydrous DMA (3.0 mL). The resulting solution wasirradiated in a microwave reactor (Biotage Initiator Eight EXP) with a 2 minprestirring period, followed by 10 min at 60 C. The reaction was then heatedat 180 C for 3 h 50 min. The maximum pressure noted was 3 bar. Aftercompletion of the reaction, H2O was added to the mixture which was thenextracted with EtOAc (3 10 mL). The combined organic layers were washedwith brine (5 mL), dried over Na2SO4, filtered, and the volatiles removed invacuo. The residue was purified by column chromatography on silica gel,yielding the corresponding biaryl product.
Reference: [1] Tetrahedron Letters, 2015, vol. 56, # 11, p. 1293 - 1296
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YieldReaction ConditionsOperation in experiment
100% Acidic conditions 4-bromobenzaldehyde dimethyl acetal (9.5 g, 41.1 mmoles) and palladium tetrakistriphenyl phosphine (50 mg, 0.04 mmoles) were added to a mixture of anhydrous zinc chloride (2.1 g 15.4 mmoles) in anhydrous tetrahydrofuran (23 g), with stirring, in an inert atmosphere. A solution of Grignard A (40.3 g) was added over 4 hours to the resulting mixture, which was kept at 50°C with stirring, in an inert atmosphere. The reaction mixture was kept at 50°C for 30 minutes and then cooled to 20-25°C. An 85percent yield of 4- (3APOS;-PYRIDYL)- BENZALDEHYDE-DIMETHYL acetal, relative to the 4- bromobenzaldehyde dimethyl acetal loaded, was obtained. After acid hydrolysis, an 85percent yield of 4- (3APOS;-PYRIDYL)- BENZALDEHYDE was obtained.
85% Acidic aqueous solution 4-bromobenzaldehyde dimethyl acetal (9.5 g, 41.1 mmoles) and palladium tetrakistriphenyl phosphine (50 mg, 0.04 mmoles) were added to a mixture of anhydrous zinc chloride (2.1 g 15.4 mmoles) in anhydrous tetrahydrofuran (23 g), with stirring, in an inert atmosphere. A solution of Grignard A (40.3 g) was added over 4 hours to the resulting mixture, which was kept at 50° C. with stirring, in an inert atmosphere. The reaction mixture was kept at 50° C. for 30 minutes and then cooled to 20-25° C. An 85percent yield of 4-(3'-pyridyl)-benzaldehyde-dimethyl acetal, relative to the 4-bromobenzaldehyde dimethyl acetal loaded, was obtained. After acid hydrolysis, an 85percent yield of 4(3'-pyridyl)-benzaldehyde was obtained.
Reference: [1] Patent: WO2004/37790, 2004, A1, . Location in patent: Page 7
[2] Patent: US2006/264640, 2006, A1, . Location in patent: Page/Page column 3
[3] Patent: US5714496, 1998, A,
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Reference: [1] European Journal of Organic Chemistry, 2012, # 31, p. 6248 - 6259,12
[2] European Journal of Organic Chemistry, 2012, # 31, p. 6248 - 6259
[3] Advanced Synthesis and Catalysis, 2017, vol. 359, # 4, p. 616 - 622
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Reference: [1] European Journal of Organic Chemistry, 2009, # 13, p. 2051 - 2054
[2] Advanced Synthesis and Catalysis, 2008, vol. 350, # 6, p. 846 - 862
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  • [ 1120-90-7 ]
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Reference: [1] Advanced Synthesis and Catalysis, 2011, vol. 353, # 11-12, p. 1889 - 1896
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Reference: [1] Journal of Organic Chemistry, 2004, vol. 69, # 6, p. 2210 - 2212
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Reference: [1] Dalton Transactions, 2014, vol. 43, # 26, p. 10235 - 10247
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  • [ 114615-82-6 ]
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Reference: [1] Patent: US5985901, 1999, A,
[2] Patent: US6156772, 2000, A,
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Reference: [1] Tetrahedron Letters, 2004, vol. 45, # 20, p. 3909 - 3912
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Reference: [1] Tetrahedron, 2013, vol. 69, # 2, p. 902 - 909
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