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Chemical Structure| 127783-73-7 Chemical Structure| 127783-73-7

Structure of 127783-73-7

Chemical Structure| 127783-73-7

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Product Details of [ 127783-73-7 ]

CAS No. :127783-73-7
Formula : C15H11F3O2
M.W : 280.24
SMILES Code : O=C(C1=CC=C(C2=CC=C(C(F)(F)F)C=C2)C=C1)OC
MDL No. :MFCD06204112

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Application In Synthesis of [ 127783-73-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 127783-73-7 ]

[ 127783-73-7 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 127783-73-7 ]
  • [ 457889-46-2 ]
YieldReaction ConditionsOperation in experiment
93% Example 107; 3-{4-[1-(4'-Trifluoromethyl-biphenyl-4-ylmethyl)-propoxy]-benzoylamino}- propionic acid; Step A. (4'-Trifluoromethyl-biphenyl-4-yl)-methanol; To a solution of 4'-trifluoromethyl-biphenyl-4-carboxylic acid methyl ester (3.71g, 13.3mmol) in tetrahydro-furan (30mL) is added lithium aluminum hydride (14.6 mmol, 1.0 M in tetrahydro-furan) at 0 C under inert atmosphere of nitrogen. After the reaction is stirred at 0 C for 10 minutes following completion of hydride addition, it is quenched with ethyl acetate (lOmL) followed by potassium hydrogen sulfate (1.0 M, 15mmol) slowly at 0 C, diluted mixture with ethyl ether and filtered. Organic layers are washed with brine, dried over sodium sulfate, filtered, and then concentrated under reduced pressure. Column chromatography (silica gel) with 20-80% ethyl acetate/hexane gradient gives 3.1g (12.3mmol, 93%) of title compound.
  • 2
  • [ 588-72-7 ]
  • [ 455-13-0 ]
  • C26H31IN2NiO2 [ No CAS ]
  • [ 127783-73-7 ]
  • [ 581-80-6 ]
  • [ 1149-56-0 ]
  • [ 792-74-5 ]
  • [ 1149-18-4 ]
 

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