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Chemical Structure| 127828-22-2 Chemical Structure| 127828-22-2
Chemical Structure| 127828-22-2

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Amino-PEG2-NH-Boc is a 2-unit PEG derivative with an amino group and a Boc (tert-butoxycarbonyl) protecting group. It is often used in peptide synthesis and bioconjugation.

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Product Details of Amino-PEG2-NH-Boc

CAS No. :127828-22-2
Formula : C9H20N2O3
M.W : 204.27
SMILES Code : O=C(OC(C)(C)C)NCCOCCN
MDL No. :MFCD12031501
InChI Key :VULKFBHOEKTQSF-UHFFFAOYSA-N
Pubchem ID :12106198

Safety of Amino-PEG2-NH-Boc

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H332-H335
Precautionary Statements:P261-P280-P305+P351+P338

Application In Synthesis of Amino-PEG2-NH-Boc

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 127828-22-2 ]

[ 127828-22-2 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 42017-89-0 ]
  • [ 127828-22-2 ]
  • [ 1286173-97-4 ]
YieldReaction ConditionsOperation in experiment
35% With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20℃; for 18h; tert-Butyl 2-(2-aminoethoxy)ethylcarbamate (300 mg, 1.47 mmol) was taken up in CH2Cl2 (15 mL) along with <strong>[42017-89-0]2-(4-(4-chlorobenzoyl)phenoxy)-2-methylpropanoic acid</strong> (<strong>[42017-89-0]fenofibric acid</strong>, 467 mg, 1.47 mmol) and EDCI (310 mg, 1.47 mmol). The resulting reaction mixture was stirred at room temperature for 18 h. It was then brine, dried over Na2SO4, filtered and concentrated under reduced pressure. The resulting residue was purified by silica gel chromatography (9:1 CH2Cl2/MeOH) to afford tert-butyl 2-(2-(2-(4-(4-chlorobenzoyl)phenoxy)-2-methylpropanamido)ethoxy)ethylcarbamate (260 mg, 35%).
 

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