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Chemical Structure| 128899-31-0 Chemical Structure| 128899-31-0

Structure of 128899-31-0

Chemical Structure| 128899-31-0

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Product Details of [ 128899-31-0 ]

CAS No. :128899-31-0
Formula : C12H15NO4S
M.W : 269.32
SMILES Code : O=S(C1=CC=C(C)C=C1)(OC[C@@H](CC2)NC2=O)=O
MDL No. :MFCD09864865

Safety of [ 128899-31-0 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501

Application In Synthesis of [ 128899-31-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 128899-31-0 ]
  • Downstream synthetic route of [ 128899-31-0 ]

[ 128899-31-0 ] Synthesis Path-Upstream   1~1

  • 1
  • [ 128899-31-0 ]
  • [ 98612-60-3 ]
YieldReaction ConditionsOperation in experiment
90% With lithium bromide In acetone at 80℃; To a solution of (R)-(5-oxopyrrolidin-2-yl)methyl 4-methylbenzenesulfonate (5.0 g, 18.5 mmol) in acetone (10 mL) was added lithium bromide (4.8 g, 55.6 mmol) and the reaction mixture stirred at 80 00 overnight. The solvent was then removed in vacuo and the reaction mixture partitioned between H20 (50 mL) and EtOAc (100 mL). The aqueous layer was extracted with EtOAc (2 x 100 mL), combined organics dried(Na2504), the solvent removed in vacuo and the residue purified by column chromatography (normal basic activated alumina, at 0.2 to 1.0 percent MeOH in DOM) to give (R)-5-(bromomethyl)pyrrolidin-2-one (3.0 g, 90 percent) as a light yellow liquid.LCMS (Method F): m/z 178/180 (M+H) (ES), at 2.24 mm, UV active
References: [1] Patent: WO2017/21728, 2017, A1, . Location in patent: Page/Page column 45; 46.
 

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