* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
2,6-Bis-tert-butoxycarbonylamino-hexanoic acid[ No CAS ]
2-[2-(2-{(S)-2,6-Bis-[(S)-2,6-bis-((S)-2,6-diamino-hexanoylamino)-hexanoylamino]-hexanoylamino}-tetradecanoylamino)-tetradecanoylamino]-tetradecanoic acid amide[ No CAS ]
2-tert-Butoxycarbonylamino-tetradecanoic acid (3aR,6aR,7aS,8S,11aS,11bS,11cS)-2-methoxy-3,8,11a,11c-tetramethyl-1,5,11-trioxo-1,3a,4,5,6a,7,7a,8,11,11a,11b,11c-dodecahydro-6-oxa-benzo[de]anthracen-10-yl ester[ No CAS ]
2-{(S)-2,6-Bis-[(S)-2,6-bis-((S)-2,6-diamino-hexanoylamino)-hexanoylamino]-hexanoylamino}-tetradecanoic acid [1-(carbamoylmethyl-carbamoyl)-tridecyl]-amide[ No CAS ]
2-{(S)-2,6-Bis-[(S)-2,6-bis-((S)-2-amino-5-guanidino-pentanoylamino)-hexanoylamino]-hexanoylamino}-tetradecanoic acid [1-(carbamoylmethyl-carbamoyl)-tridecyl]-amide[ No CAS ]
2-tert-Butoxycarbonylamino-tetradecanoic acid (3aR,6aR,7aS,8S,11aS,11bS,11cS)-5-hydroxy-2-methoxy-3,8,11a,11c-tetramethyl-1,11-dioxo-1,3a,4,5,6a,7,7a,8,11,11a,11b,11c-dodecahydro-6-oxa-benzo[de]anthracen-10-yl ester[ No CAS ]
(6R,7R)-7-<2-<(2R,2S)-2-aminotetradecanoylamino>(thiazol-4-ylacetamido)>-3-carbamoyloxymethyl-2,3-didehydro-8-oxo-5-thia-1-azabicyclo<4.2.0>octane-2-carboxylic acid[ No CAS ]
(6R,7R)-diphenylmethyl 7-<2-<(2R,2S)-2-(tertbutoxycarbamido)tetradecanamido>(thiazol-4-ylacetamido)>-3-carbamoyloxymethyl-2,3-didehydro-8-oxo-5-thia-1-azabicyclo<4.2.0>octane-2-carboxylate[ No CAS ]
With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20℃; for 12h;
General procedure: 2-(Nα-Boc)amino-d,l-heptanoic acid 1a7 (1.11 g, 4.28 mmol), HBTU (0.97 g, 5.14 mmol) and DIPEA (1.49 ml, 8.52 mmol) were dissolved in dry DCM (50 ml) followed by the addition of dimethyl glutamic acid 214 (0.75 g, 4.28 mmol). The reaction mixture was stirred at room temperature for 12 h, then washed with 5% HCl (2×50 mL) and a saturated solution of NaHCO3 (2×50 mL), and dried over MgSO4. The residual solvent was evaporated under vacuum and the crude product was purified by column chromatography (Rf=0.3 ethyl acetate/hexane, 1:2 (v/v)) to produce pure compound 3a (1.15 g, 2.76 mmol, 65%) as a colourless oil (1:1 mixture of diastereomers).