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Chemical Structure| 130284-00-3 Chemical Structure| 130284-00-3

Structure of 130284-00-3

Chemical Structure| 130284-00-3

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Product Details of [ 130284-00-3 ]

CAS No. :130284-00-3
Formula : C12H9Br2NO
M.W : 343.01
SMILES Code : BrC1=CN=C(OCC2=CC=CC=C2)C(Br)=C1
MDL No. :MFCD20441927

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Application In Synthesis of [ 130284-00-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 130284-00-3 ]

[ 130284-00-3 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 75806-85-8 ]
  • [ 100-51-6 ]
  • [ 130284-00-3 ]
YieldReaction ConditionsOperation in experiment
55% With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 - 20℃; for 3h; Step 1 : A solution of 2,3,5 -tribromopyridine (1.0 equiv.) in N,N- dimethylformamide (0.2 M) was treated with sodium hydride (60% dispersion in mioei 1.3 equiv.). The mixture was cooled to 0 C and BzOH (1.0 equiv.) was added slowly. The resultant mixture was stirred at 0 C for 2 h and room temperature for 1 hour, then was added to dilute brine solution and was extracted with ethyl acetate. The organic layer was dried over magnesium sulfate, filtered, and the solvent was removed in vacuo. Purified by ISCO(0-100 % EtO Ac/heptane) to yield 2-(betizyloxy)-3,5-dibromopyridine in 55 % yield. LCMS (m/z) (M+H) = 342.0/344.0, Rt = 1.20 mm.
 

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