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Chemical Structure| 1304782-97-5 Chemical Structure| 1304782-97-5

Structure of 1304782-97-5

Chemical Structure| 1304782-97-5

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Product Details of [ 1304782-97-5 ]

CAS No. :1304782-97-5
Formula : C13H16FNO2
M.W : 237.27
SMILES Code : O=C(N1CCC2=C1C=CC(F)=C2)OC(C)(C)C

Safety of [ 1304782-97-5 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H332-H335
Precautionary Statements:P261-P280-P305+P351+P338

Application In Synthesis of [ 1304782-97-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1304782-97-5 ]

[ 1304782-97-5 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 2343-22-8 ]
  • [ 24424-99-5 ]
  • [ 1304782-97-5 ]
YieldReaction ConditionsOperation in experiment
81% In tetrahydrofuran; at 20℃; A procedure similar to that described in Iwao, M.; Kuraishi, T. Heterocycles 1992, 34, 1031 was used. A solution of <strong>[2343-22-8]5-fluoroindoline</strong> (100 mg, 0.73 mmol) and di-tert-butyl dicarbonate (188 mg, 0.86 mmol) in 2 mL THF was stirred at room temperature overnight. At this time, 20 mL saturated NaHC03 solution was added and the mixture was extracted with ethyl acetate (20 mL). The ethyl acetate solution was then dried (Na2S04), filtered and evaporated. Purification of the residue by flash chromatography on silica gel using a Combiflash unit by Teledyne Isco (0% ethyl acetate/hexanes 20%) gave the title compound (140 mg, 81%).
 

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