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Chemical Structure| 1310383-78-8 Chemical Structure| 1310383-78-8

Structure of 1310383-78-8

Chemical Structure| 1310383-78-8

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Product Details of [ 1310383-78-8 ]

CAS No. :1310383-78-8
Formula : C14H16BNO5S
M.W : 321.16
SMILES Code : COC1=CC=C(B(O)O)C=C1S(=O)(NCC2=CC=CC=C2)=O
MDL No. :MFCD08235069

Safety of [ 1310383-78-8 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319
Precautionary Statements:P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330

Application In Synthesis of [ 1310383-78-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1310383-78-8 ]

[ 1310383-78-8 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 33930-63-1 ]
  • [ 1310383-78-8 ]
  • N-benzyl-2-methoxy-5-(2-methyl-1-oxoisoquinolin-4-yl)benzenesulfonamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
58% With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate; In 1,4-dioxane; water; at 120℃; for 1.0h;Inert atmosphere; Microwave irradiation; For about 3 min, N2 was bubbled through the mixture of <strong>[33930-63-1]4-bromo-2-methylisoquinolin-1(2H)-one</strong> (56 mg, 0.24 mmol), [3-(benzylsulfamoyl)-4-methoxyphenyl]boronic acid (83 mg, 0.26 mmol), aqueous 2M Na2CO3 (0.375 mL) and Pd(dppf)Cl2 (9 mg, 0.001 mmol) in dioxane (1.5 mL) which was then microwaved at 120° C. for 1 h and then filtered through a plug of anhydrous Na2SO4 using ethyl acetate to transfer and rinse. Silica gel chromatography, eluting with 0-60percent EA in hexane over 6 min and continuing 60percent isocratic EA gave the title compound (60 mg, 0.14 mmol) as a white solid in 58percent yield. 1H NMR (400 MHz, DMSO-d6) delta 3.57 (s, 3H), 3.89 (s, 3H), 4.11 (d, J=6.32 Hz, 2H), 7.16-7.23 (m, 6H), 7.34 (d, J=8.08 Hz, 1H), 7.47 (s, 1H), 7.53-7.59 (m, 2H), 7.65 (d, J=2.27 Hz, 1H), 7.72-7.77 (m, 1H), 7.94 (t, J=6.32 Hz, 1H), 8.34 (d, J=7.33 Hz, 1H). LCMS (M+H)+ 435.
 

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