Alternatived Products of [ 1312772-66-9 ]
Product Details of [ 1312772-66-9 ]
CAS No. : | 1312772-66-9 |
MDL No. : | MFCD24499931 |
Formula : |
C7H5ClN2O3
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Boiling Point : |
- |
Linear Structure Formula : | - |
InChI Key : | - |
M.W : |
200.58
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Pubchem ID : | - |
Synonyms : |
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Safety of [ 1312772-66-9 ]
Signal Word: | |
Class: | |
Precautionary Statements: | |
UN#: | |
Hazard Statements: | |
Packing Group: | |
Application In Synthesis of [ 1312772-66-9 ]
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
- Upstream synthesis route of [ 1312772-66-9 ]
- Downstream synthetic route of [ 1312772-66-9 ]
- 1
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[ 28900-10-9 ]
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[ 1312772-66-9 ]
Yield | Reaction Conditions | Operation in experiment |
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EXAMPLE 216-(4-chlorobenzylthio)-5-cyanopicolinic acid (52) <n="101"/> Step 1Synthesis of 6-chloro-5-cyanopicolinic acid (51) To a solution of 6-chloro-5-cyano-2-picoline 50 (3.0 g, 20 mmol) in COnC-H2SO4 (20 ml) was added CrO3 (4.9 g, 49 mmol) portionwise over 2 hr period while the reaction mixture was kept below 2O 0 C. After stirring overnight at room temperature, the mixture was poured into ice-water and the resulting solid was collected by filtration to give the crude 6-chloro-5-(aminocarbonyl)-2-picolinic acid which was dissolved in POCl3 (15 ml). After heating at reflux for 30 min, the reaction mixture was concentrated in vacuo and the residue was treated with ice water. The precipitate was collected by filtration to afford 2.5 g (71% for 2 steps) of the desired product 51. 1H NMR (600MHz, DMSO-d6) delta 8.65 (delta, IH, theta= 7.8 Hzeta), 8.17 (delta, IH, theta= 7.8 Hzeta) |
- 2
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[ 1312772-66-9 ]
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[ 53234-56-3 ]
Yield | Reaction Conditions | Operation in experiment |
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EXAMPLE 216-(4-chlorobenzylthio)-5-cyanopicolinic acid (52) <n="101"/> Step 1Synthesis of 6-chloro-5-cyanopicolinic acid (51) To a solution of 6-chloro-5-cyano-2-picoline 50 (3.0 g, 20 mmol) in COnC-H2SO4 (20 ml) was added CrO3 (4.9 g, 49 mmol) portionwise over 2 hr period while the reaction mixture was kept below 2O 0 C. After stirring overnight at room temperature, the mixture was poured into ice-water and the resulting solid was collected by filtration to give the crude 6-chloro-5-(aminocarbonyl)-2-picolinic acid which was dissolved in POCl3 (15 ml). After heating at reflux for 30 min, the reaction mixture was concentrated in vacuo and the residue was treated with ice water. The precipitate was collected by filtration to afford 2.5 g (71% for 2 steps) of the desired product 51. 1H NMR (600MHz, DMSO-d6) delta 8.65 (delta, IH, theta= 7.8 Hzeta), 8.17 (delta, IH, theta= 7.8 Hzeta) |