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Chemical Structure| 1312941-98-2 Chemical Structure| 1312941-98-2

Structure of 1312941-98-2

Chemical Structure| 1312941-98-2

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Product Details of [ 1312941-98-2 ]

CAS No. :1312941-98-2
Formula : C14H8BrF2N3O
M.W : 352.13
SMILES Code : O=C(C1=C(F)C=CC(N)=C1F)C2=CNC3=NC=C(Br)C=C32
MDL No. :MFCD28384819

Safety of [ 1312941-98-2 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319
Precautionary Statements:P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313

Application In Synthesis of [ 1312941-98-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1312941-98-2 ]

[ 1312941-98-2 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 6608-47-5 ]
  • [ 1312941-98-2 ]
  • N-(3-[5-bromo-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]-2,4-difluorophenyl)ethene-1-sulfonamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
48% With pyridine; dmap; In dichloromethane; at 20℃; for 0.5h; Intermediate 3: N-(3-[5-bromo-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]-2,4-difluorophenyl)-2-(dimethylamino)ethane-1-sulfonamide Step A: N-(3-[5-bromo-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]-2,4-difluorophenyl)ethene-1-sulfonamide Into a 100 mL round-bottom flask, was placed 3-[5-bromo-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]-2,4-difluoroaniline (500 mg, 1.42 mmol, 1 equiv), pyridine (20 mL, 248.47 mmol, 174.99 equiv), DMAP (35 mg, 0.29 mmol, 0.20 equiv), <strong>[6608-47-5]ethenesulfonyl chloride</strong> (360 mg, 2.84 mmol, 2.00 equiv), dichloromethane (20 mL). The resulting solution was stirred for 0.5 hour at room temperature. The reaction mixture was concentrated under reduced pressure. The residue was applied onto a silica gel column eluting with ethyl acetate/petroleum ether (1:1). This resulted in 300 mg (48%) of N-(3-[5-bromo-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]-2,4-difluorophenyl)ethene-1-sulfonamide as a white solid. LCMS (ES+): m/z 443.80[M+H]+.
 

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