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Chemical Structure| 131472-28-1 Chemical Structure| 131472-28-1

Structure of 131472-28-1

Chemical Structure| 131472-28-1

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Product Details of [ 131472-28-1 ]

CAS No. :131472-28-1
Formula : C8H7F3N2
M.W : 188.15
SMILES Code : N=C(N)C1=CC=C(C(F)(F)F)C=C1
MDL No. :MFCD05663380
InChI Key :XFLGYXVBXUAGQV-UHFFFAOYSA-N
Pubchem ID :2777390

Safety of [ 131472-28-1 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H317-H319
Precautionary Statements:P280-P305+P351+P338

Application In Synthesis of [ 131472-28-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 131472-28-1 ]

[ 131472-28-1 ] Synthesis Path-Downstream   1~3

  • 1
  • [ 57611-47-9 ]
  • [ 131472-28-1 ]
  • 6-benzyl-2-(4-trifluoromethylphenyl)-3,4,5,6,7,8-hexahydropyrido[4,3-d]pyrimidin-4-one [ No CAS ]
YieldReaction ConditionsOperation in experiment
60% With sodium methylate; In methanol; for 10h;Reflux; General procedure: Compound 46 (1.42 g, 5.0 mmol) was boiled under reflux with45a (600 mg, 5.0 mmol) and NaOMe (from Na (690 mg, 30 mmol))in dry MeOH (30 mL) for 10 h, then cooled. The evaporation residue,in water, was sonicated for 5 min. The suspension was keptat 2-8 C for 1 h. The solid was collected, washed (water, EtOAc)and dried to give 47a (840 mg, 53%) as an off-white powder.
  • 2
  • [ 57611-47-9 ]
  • [ 131472-28-1 ]
  • 4-oxo-2-(4-trifluoromethylphenyl)-3,4,5,6,7,8-hexahydropyrido[4,3-d]pyrimidin formate [ No CAS ]
  • 3
  • [ 38980-96-0 ]
  • [ 131472-28-1 ]
YieldReaction ConditionsOperation in experiment
With sodium hydroxide; In water; at 20℃; for 1h; General procedure: A 100 mL flask was charged with 30 mL of anhydrous MeOH, 10 mmol of the arylnitrile, and 1.0 mmol of sodium methoxide. The complex was protected from moisture and stirred for 48 h. Then, 10 mmol of NH4Cl was added and stirring was continued for 24 h. Unreacted NH4Cl was filtered, and methanol was stripped from the filtrate to afford the product aryl amidine hydrochlorides, which was dissolved in 2.5 mL 8M sodium hydroxide aqueous solution and stirred for 1 h. Then chloroform (20 ml x 3) and H2O (20 ml x 3) were added successively to extract the product, and the combined organic layer was dried with anhydrous MgSO4 and then evaporated under vacuum to remove the organic solvent to give the desired arylamidine.
 

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