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Chemical Structure| 131511-13-2 Chemical Structure| 131511-13-2

Structure of 131511-13-2

Chemical Structure| 131511-13-2

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Product Details of [ 131511-13-2 ]

CAS No. :131511-13-2
Formula : C15H21NO2
M.W : 247.33
SMILES Code : C1(NCC2=CC=CC=C2)CCC3(OCCO3)CC1
MDL No. :MFCD09037841

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Application In Synthesis of [ 131511-13-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 131511-13-2 ]

[ 131511-13-2 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 131511-13-2 ]
  • [ 142009-99-2 ]
YieldReaction ConditionsOperation in experiment
95.6% With hydrogenchloride; In water; at 20℃; for 22h; Loaded with N-benzyl-1,4-dioxaspiro[4.5]silane-8-amine (16g, 64.69mmol, 1eq.)Of single-mouth bottle with 2mol/L HCl(81ml, 161.72mmol, 2.5eq.), stirred at room temperature overnight (12h),TLC (DCM:MeOH=25:1, 2 times) about half of the raw materials remained.After adding 2mol/L HCl (16ml, 0.5 eq.) for 10hTLC showed that the reaction was basically complete. Under the ice bath, Add NaOH (8g, about 3eq.) in water (about 24ml) solution,Adjust pH 910 with 2mol/L NaOH solution.Extract with dichloromethane (150+75+30 ml). The organic phase is combined,Wash with saturated sodium chloride (30ml), dry with anhydrous magnesium sulfate, filter with suction,The filtrate was evaporated under reduced pressure to obtain 12.57g of light brown liquid.The yield was 95.6%.
 

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