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Chemical Structure| 132234-68-5 Chemical Structure| 132234-68-5

Structure of 132234-68-5

Chemical Structure| 132234-68-5

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Product Details of [ 132234-68-5 ]

CAS No. :132234-68-5
Formula : C12H22N2O2
M.W : 226.32
SMILES Code : N(C(OC(C)(C)C)=O)[C@H]1C[C@H]2N[C@@H](C1)CC2
MDL No. :MFCD16661075
InChI Key :UUHPKKKRSZBQIG-ULKQDVFKSA-N
Pubchem ID :14774663

Safety of [ 132234-68-5 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501

Application In Synthesis of [ 132234-68-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 132234-68-5 ]

[ 132234-68-5 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 42860-10-6 ]
  • [ 132234-68-5 ]
  • tert-butyl N-[(3-exo)-8-(3-bromo-4-chlorobenzoyl)-8-azabicyclo[3.2.1]octan-3-yl]carbamate [ No CAS ]
YieldReaction ConditionsOperation in experiment
With triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl acetamide; at 20℃; for 1h; <strong>[42860-10-6]3-bromo-4-chlorobenzoic acid</strong> (500 mg) was dissolved in DMA (5.3 mL). At room temperature, HATU (1 g),TEA (0.59 mL), and tert-butyl N-[(3-exo)-8-azabicyclo[3.2.1]octan-3-yl]carbamate (480 mg) were added thereto, followedby stirring at room temperature for 1 hour. Ethyl acetate was added thereto, and the resulting mixture was washedsequentially with water and saturated brine. After the organic layer was dried over anhydrous sodium sulfate, the solventwas distilled off. The residue was purified by silica gel column chromatography (mobile phase: hexane/ethyl acetate) togive tert-butyl N-[(3-exo)-8-(3-bromo-4-chlorobenzoyl)-8-azabicyclo[3.2.1]octan-3-yl]carbamate.
 

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