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Chemical Structure| 1331786-28-7 Chemical Structure| 1331786-28-7

Structure of 1331786-28-7

Chemical Structure| 1331786-28-7

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Product Details of [ 1331786-28-7 ]

CAS No. :1331786-28-7
Formula : C8H6BrCl2F
M.W : 271.94
SMILES Code : FC1=CC=C(Cl)C(C(Br)C)=C1Cl
MDL No. :MFCD21332768

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Application In Synthesis of [ 1331786-28-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1331786-28-7 ]

[ 1331786-28-7 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 1331786-28-7 ]
  • [ 39903-01-0 ]
  • [ 756503-69-2 ]
YieldReaction ConditionsOperation in experiment
42% With potassium carbonate; In N,N-dimethyl-formamide; for 6h;Inert atmosphere; Step 2: 5-bromo-3-(1-(2,6-dichloro-3-fluorophenyl)ethyoxyl)-2-aminopyridine 1,3-Dichloro-2-(1-bromoethyl)-4-fluorobenzene (25.8 g, 95 mmol), <strong>[39903-01-0]2-amino-5-bromo-pyridin-3-ol</strong> (28.7 g, 152 mmol), and K2CO3 (26.2 g, 190 mmol) were added into DMF (400 mL) at room temperature. Upon completion of the addition, the resultant was reacted for 6 hours under a nitrogen atmosphere. The solution was concentrated, CH2Cl2 was added, and the resultant was washed with water, dried, concentrated, and purified by silica gel column chromatography to give 5-bromo-3-(1-(2,6-dichloro-3-fluorophenyl)ethyoxyl)-2-aminopyridine (15.2 g, 42percent yield). MS m/z [ESI]: 380.9 [M+1].
 

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