Name: 13379-98-1|N-(3-Hydroxypropyl)-4-methylbenzenesulfonamide|95%
Brand: Ambeed
SKU: A609669
Rating: 98 (40 reviews)

1
[ 13379-98-1 ]
[ 3245-95-2 ]

Yield	Reaction Conditions	Operation in experiment
29%
	With hydrogen bromide In acetic acid

Reference： [1]Schirrmacher, Ralf; Mathiasch, Bernd; Schirrmacher, Esther; Radnic, Dragana; Roesch, Frank [Journal of labelled compounds and radiopharmaceuticals, 2003, vol. 46, # 10, p. 959 - 977]
[2]Augstein,J. et al. [Journal of Medicinal Chemistry, 1965, vol. 8, p. 356 - 367]

2
[ 98-59-9 ]
[ 156-87-6 ]
[ 13379-98-1 ]

Yield	Reaction Conditions	Operation in experiment
100%	With triethylamine In dichloromethane at 20℃; for 1h; Inert atmosphere;
99%	With triethylamine In dichloromethane at 0℃; for 17h;
99%	With triethylamine In chloroform at 0 - 20℃; for 18h; Inert atmosphere;

99%	With triethylamine In chloroform at 0 - 20℃; for 18h; Inert atmosphere;	1 N-(3-Hydroxypropyl)-4-methylbenzenesulfonamide (I) [00029] To a cooled (0 °C) mixture of 3-aminopropan-1-ol (1.9 mL, 24.8 mmol) and Et3N (6.9 mL, 49.6 mmol, 2.0 equiv) in chloroform (4.0 mL) was added a solution ofptoluenesulfonyl chloride (5.21 g, 14.38 mmol, 1.1 equiv) in chloroform (6.0 mL, 2.5 M overall). The mixture was allowed to slowly warm to ambient temperature and stir under inert atmosphere for 18 h. The reaction was then quenched with 5% NaHCO3, and the mixture was extracted with EtOAc (x3). The combined organic layers were washed successively with 5% citric acid, water, 5% NaHCO3, and brine. Then the organic layers were dried over Mg504, filtered, and concentrated in vacuo to provide N-(3-hydroxypropyl)-4-methylbenzenesulfonamide (5.70 g, 24.8 mmol, 99% yield). Carried on to next step without further purification.[00030] Analytical data for I: ‘HNMR (400 MFIz, CDC13) 7.76 (d, J 8.3 Hz, 2H), 7.35-7.29 (m, 2H), 5.62 (t, J 6.1 Hz, 1H), 3.70 (t, J= 5.8 Hz, 2H), 3.07 (q, J= 6.3 Hz, 2H),2.74 (s, 1H), 2.43 (s, 3H), 1.71 (ap p, J= 6.0 Hz, 2H). ‘HNMR data for this product corresponds with literature values.
91%	With triethylamine In chloroform at 0 - 20℃; for 19h;
90%	With triethylamine In dichloromethane at 0℃; for 5h;
90%	With triethylamine at 20℃;
88%	With triethylamine In dichloromethane
84%	With anhydrous sodium carbonate In water monomer for 6.5h;
80%	With triethylamine In dichloromethane at 0 - 20℃;
80%	With triethylamine In dichloromethane at 0 - 20℃;
79%	With triethylamine In dichloromethane at 0℃; for 0.25h;
78%
68%	With triethylamine In dichloromethane at 0 - 25℃; for 1h;
68%	With triethylamine In dichloromethane at 0℃; for 0.5h;
68%	With triethylamine In dichloromethane at 0℃; for 0.5h;
	With potassium carbonate In N,N-dimethyl-formamide at 125℃;
	With triethylamine In tetrahydrofuran; water monomer at 0 - 20℃;
	With triethylamine In dichloromethane at 20℃; for 16h;
	With triethylamine In dichloromethane at 5℃; for 24h;
	With triethylamine In dichloromethane at 0 - 20℃; for 13h;
	With triethylamine In chloroform at 0 - 20℃;
	In ethyl acetate at 20℃; for 2h;	Typical procedure for the synthesis of starting materials General procedure: Tosylation: To a solution of p-toluenesulfonyl chloride (5 mmol, 1.0 equiv) in EtOAc (10 mL) was added proper alkanolamine (10 mmol, 2.0 equiv). The reaction mixture was stirred for 2 hours at room temperature. After completion of the reaction, the mixture was filtered through silica and washed with EtOAc. The residue was concentrated to give products, which were used to next step without further purification.
	With triethylamine at 0 - 20℃; for 24h;
	With triethylamine In dichloromethane at 0 - 20℃; for 10h;
	With triethylamine In dichloromethane at 0 - 20℃; Inert atmosphere;
	With pyridine In dichloromethane at 0 - 20℃; for 1h;

Reference： [1]Beltran, Frédéric; Fabre, Indira; Ciofini, Ilaria; Miesch, Laurence [Organic Letters, 2017, vol. 19, # 19, p. 5042 - 5045]
[2]Ohno, Hiroaki; Miyamura, Kumiko; Tanaka, Tetsuaki; Oishi, Shinya; Toda, Ayako; Takemoto, Yoshiji; Fujii, Nobutaka; Ibuka, Toshiro [Journal of Organic Chemistry, 2002, vol. 67, # 4, p. 1359 - 1367]
[3]Younai, Ashkaan; Zeng, Bi-Shun; Meltzer, Herbert Y.; Scheidt, Karl A. [Angewandte Chemie - International Edition, 2015, vol. 54, # 23, p. 6900 - 6904][Angew. Chem., 2015, vol. 54-127, # 23, p. 7004 - 7008]
[4]Current Patent Assignee: NORTHWESTERN UNIVERSITY (ILLINOIS) - WO2016/179184, 2016, A2 Location in patent: Paragraph 00029; 00030
[5]Kokotos, Christoforos G.; Aggarwal, Varinder K. [Chemical Communications, 2006, # 20, p. 2156 - 2158]
[6]Poloukhtine, Andrei; Popik, Vladimir V. [Journal of the American Chemical Society, 2007, vol. 129, # 40, p. 12062 - 12063]
[7]Comito, Robert J.; Finelli, Fernanda G.; Macmillan, David W. C. [Journal of the American Chemical Society, 2013, vol. 135, # 25, p. 9358 - 9361]
[8]Greenaway, Rebecca L.; Campbell, Craig D.; Chapman, Helen A.; Anderson, Edward A. [Advanced Synthesis and Catalysis, 2012, vol. 354, # 17, p. 3187 - 3194]
[9]Angle, Steven R.; Belanger, Dominique S. [Journal of Organic Chemistry, 2004, vol. 69, # 13, p. 4361 - 4368]
[10]Elliott, Luke D.; Wrigglesworth, Joe W.; Cox, Brian; Lloyd-Jones, Guy C.; Booker-Milburn, Kevin I. [Organic Letters, 2011, vol. 13, # 4, p. 728 - 731]
[11]He, Tian; Gao, Wen-Chao; Wang, Wei-Kun; Zhang, Chi [Advanced Synthesis and Catalysis, 2014, vol. 356, # 5, p. 1113 - 1118]
[12]Bailey, Thomas R.; Garigipati, Ravi S.; Morton, Judith A.; Weinreb, Steven M. [Journal of the American Chemical Society, 1984, vol. 106, # 11, p. 3240 - 3245]
[13]Schirrmacher, Ralf; Mathiasch, Bernd; Schirrmacher, Esther; Radnic, Dragana; Roesch, Frank [Journal of labelled compounds and radiopharmaceuticals, 2003, vol. 46, # 10, p. 959 - 977]
[14]Walker, Stephen M.; Williams, Jodi T.; Russell, Alexander G.; Snaith, John S. [Tetrahedron Letters, 2005, vol. 46, # 39, p. 6611 - 6615]
[15]Williams, Jodi T.; Bahia, Perdip S.; Kariuki, Benson M.; Spencer, Neil; Philp, Douglas; Snaith, John S. [Journal of Organic Chemistry, 2006, vol. 71, # 6, p. 2460 - 2471]
[16]Williams, Jodi T.; Bahia, Perdip Singh; Snaith, John S. [Organic Letters, 2002, vol. 4, # 21, p. 3727 - 3730]
[17]Lee; Hashimoto; Ohta; Shudo; Okamoto [Chemical and Pharmaceutical Bulletin, 1982, vol. 30, # 8, p. 3046 - 3049]
[18]Augstein,J. et al. [Journal of Medicinal Chemistry, 1965, vol. 8, p. 356 - 367] Drandarov, Konstantin; Guggisberg, Armin; Hesse, Manfred [Helvetica Chimica Acta, 2002, vol. 85, # 4, p. 979 - 989]
[19]Zhao, Yu-Jun; Loh, Teck-Peng [Journal of the American Chemical Society, 2008, vol. 130, # 30, p. 10024 - 10029]
[20]Bandini, Marco; Monari, Magda; Romaniello, Alessandro; Tragni, Michele [Chemistry - A European Journal, 2010, vol. 16, # 48, p. 14272 - 14277]
[21]Location in patent: experimental part Nan; David; Tintas; Lar; Grosu [Letters in Organic Chemistry, 2011, vol. 8, # 1, p. 16 - 21]
[22]Babu, Beneesh P.; Endo, Yoshinori; Baeckvall, Jan-E. [Chemistry - A European Journal, 2012, vol. 18, # 37, p. 11524 - 11527,4]
[23]Campbell, Craig D.; Greenaway, Rebecca L.; Holton, Oliver T.; Walker, P. Ross; Chapman, Helen A.; Russell, C. Adam; Carr, Greg; Thomson, Amber L.; Anderson, Edward A. [Chemistry - A European Journal, 2015, vol. 21, # 36, p. 12627 - 12639]
[24]Hwang, Joon Young; Shin, Jung Ha; Seong, Eun Young; Kang, Eun Joo [Bulletin of the Korean Chemical Society, 2018, vol. 39, # 5, p. 695 - 698]
[25]Chen, Anrong; Yu, Houjian; Yan, Jiaqi; Huang, Hanmin [Organic Letters, 2020, vol. 22, # 2, p. 755 - 759]
[26]Chen, Yang-Bo; Sun, Zhou; Wang, Ze-Shu; Ye, Long-Wu; Zhang, Hao-Wen; Zhu, Chunyin [Journal of the American Chemical Society, 2020, vol. 142, # 7, p. 3636 - 3644]
[27]Lorton, Charlotte; Saleh, Nidal; Voituriez, Arnaud [European Journal of Organic Chemistry, 2021, vol. 2021, # 22, p. 3340 - 3344]
[28]Hashimoto, Hisashi; Kawabata, Takeo; Takasu, Kiyosei; Ueda, Yoshihiro [Angewandte Chemie - International Edition, 2022, vol. 61, # 18][Angew. Chem., 2022, vol. 61, # 18]

3
[ 110-87-2 ]
[ 13379-98-1 ]
[ 109774-82-5 ]

Yield	Reaction Conditions	Operation in experiment
95%	With toluene-4-sulfonic acid In diethyl ether for 3h;
	Yield given;

Reference： [1]Bailey, Thomas R.; Garigipati, Ravi S.; Morton, Judith A.; Weinreb, Steven M. [Journal of the American Chemical Society, 1984, vol. 106, # 11, p. 3240 - 3245]
[2]Heyer, Dennis; Lehn, Jean-Marie [Tetrahedron Letters, 1986, vol. 27, # 48, p. 5869 - 5872]

4
[ 358-23-6 ]
[ 13379-98-1 ]
[ 264218-69-1 ]

Yield	Reaction Conditions	Operation in experiment
	With pyridine In dichloromethane at 0℃; for 0.333333h;

Reference： [1]Bailey, Thomas R.; Garigipati, Ravi S.; Morton, Judith A.; Weinreb, Steven M. [Journal of the American Chemical Society, 1984, vol. 106, # 11, p. 3240 - 3245]

5
[ 13379-98-1 ]
[ 718633-51-3 ]

Yield	Reaction Conditions	Operation in experiment
79%	With sodium periodate; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; sodium bromide In dichloromethane; water at 35℃; Inert atmosphere;
79%	With sodium periodate; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; sodium bromide In dichloromethane; water at 35℃; for 18h; Inert atmosphere;	2 4-Methyl-N-(3-oxopropyl)benzenesulfonamide (II) [00031] To a mixture of N-(3 -hydroxypropyl)-4-methylbenzenesulfonamide (1.15 g, 5.00 mmol), TEMPO (0.078 g, 0.50 mmol, 0.10 equiv), NaTO4 (1.77 g, 8.25 mmol, 1.65 equiv) and NaBr (0.085 g, 0.825 mmol, 0.165 equiv) was added CH2C12/H20 (45:55, 20.0 mL, 0.25 M). The resulting biphasic mixture was heated to 35 °C. Upon completion of the reaction (18 h; monitored by TLC), the organic layer was separated, and the aqueous layer was extracted with CH2C12. The combined organic layers were concentrated in vacuo, and the residue was partitioned between EtOAc and sat. aq. Na2 S203. The organic layer was then washed successively with H20 and brine, dried over MgSO4, filtered, and concentrated in vacuo. Purification by column chromatography (40:60 to 50:50 EtOAc/hexanes) provided 4-methyl-N- (3-oxopropyl)benzenesulfonamide (0.903 g, 3.97 mmol, 79% yield) as a yellow oil.[00032] Analytical data for II: ‘HNMR (500 IVIFIz, CDC13) 9.73 (s, 1H), 7.74 (d, J 8.3 Hz, 2H), 7.32 (d, J= 8.0 Hz, 2H), 4.92 (t, J= 6.6 Hz, 1H), 3.21 (q, J 6.1 Hz, 2H), 2.75 (t, J = 5.8 Hz, 2H), 2.43 (s, 3H). ‘H NMR data for this product corresponds with literature values.
78%	With Dess-Martin periodane In dichloromethane for 5h;

66%	With Dess-Martin periodane In dichloromethane at 0 - 20℃; for 16h; Inert atmosphere;
65%	With oxalyl dichloride; dimethyl sulfoxide; diisopropylamine In dichloromethane at -78 - 0℃; for 1.33333h;
	With oxalyl dichloride; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine In dichloromethane at -78℃; for 1.33333h;
	With pyridinium chlorochromate In dichloromethane at 0℃; for 2h; Molecular sieve;
2.15 g	With oxalyl dichloride; dimethyl sulfoxide; triethylamine In dichloromethane at -78 - 20℃; Inert atmosphere;

Reference： [1]Younai, Ashkaan; Zeng, Bi-Shun; Meltzer, Herbert Y.; Scheidt, Karl A. [Angewandte Chemie - International Edition, 2015, vol. 54, # 23, p. 6900 - 6904][Angew. Chem., 2015, vol. 54-127, # 23, p. 7004 - 7008]
[2]Current Patent Assignee: NORTHWESTERN UNIVERSITY (ILLINOIS) - WO2016/179184, 2016, A2 Location in patent: Paragraph 00031; 00032
[3]Angle, Steven R.; Belanger, Dominique S. [Journal of Organic Chemistry, 2004, vol. 69, # 13, p. 4361 - 4368]
[4]Serpier, Fabien; Flamme, Benjamin; Brayer, Jean-Louis; Folléas, Benoît; Darses, Sylvain [Organic Letters, 2015, vol. 17, # 7, p. 1720 - 1723]
[5]Kokotos, Christoforos G.; Aggarwal, Varinder K. [Chemical Communications, 2006, # 20, p. 2156 - 2158]
[6]Ohno, Hiroaki; Miyamura, Kumiko; Tanaka, Tetsuaki; Oishi, Shinya; Toda, Ayako; Takemoto, Yoshiji; Fujii, Nobutaka; Ibuka, Toshiro [Journal of Organic Chemistry, 2002, vol. 67, # 4, p. 1359 - 1367]
[7]Okano, Akinori; Tsukamoto, Koji; Kosaka, Shohei; Maeda, Hatsuo; Oishi, Shinya; Tanaka, Tetsuaki; Fujii, Nobutaka; Ohno, Hiroaki [Chemistry - A European Journal, 2010, vol. 16, # 28, p. 8410 - 8418]
[8]Lorton, Charlotte; Saleh, Nidal; Voituriez, Arnaud [European Journal of Organic Chemistry, 2021, vol. 2021, # 22, p. 3340 - 3344]

6
[ 13379-98-1 ]
[ 124-63-0 ]
[ 444119-31-7 ]

Yield	Reaction Conditions	Operation in experiment
100%	With triethylamine In chloroform at 0℃; for 0.5h;

Reference： [1]Drandarov, Konstantin; Guggisberg, Armin; Hesse, Manfred [Helvetica Chimica Acta, 2002, vol. 85, # 4, p. 979 - 989]

7
[ 21378-06-3 ]
[ 13379-98-1 ]
[ 686273-50-7 ]

Yield	Reaction Conditions	Operation in experiment
62%	With caesium carbonate In N,N-dimethyl-formamide for 1.5h;
	With caesium carbonate In N,N-dimethyl-formamide at 25℃;

Reference： [1]Williams, Jodi T.; Bahia, Perdip S.; Kariuki, Benson M.; Spencer, Neil; Philp, Douglas; Snaith, John S. [Journal of Organic Chemistry, 2006, vol. 71, # 6, p. 2460 - 2471]
[2]Williams, Jodi T.; Bahia, Perdip Singh; Snaith, John S. [Organic Letters, 2002, vol. 4, # 21, p. 3727 - 3730]

8
[ 931-42-0 ]
[ 13379-98-1 ]
[ 686273-51-8 ]

Yield	Reaction Conditions	Operation in experiment
65%	With caesium carbonate In N,N-dimethyl-formamide for 1.5h;
	With caesium carbonate In N,N-dimethyl-formamide at 25℃;

Reference： [1]Williams, Jodi T.; Bahia, Perdip S.; Kariuki, Benson M.; Spencer, Neil; Philp, Douglas; Snaith, John S. [Journal of Organic Chemistry, 2006, vol. 71, # 6, p. 2460 - 2471]
[2]Williams, Jodi T.; Bahia, Perdip Singh; Snaith, John S. [Organic Letters, 2002, vol. 4, # 21, p. 3727 - 3730]

9
[ 932-86-5 ]
[ 13379-98-1 ]
[ 686273-52-9 ]

Yield	Reaction Conditions	Operation in experiment
60%	With caesium carbonate In N,N-dimethyl-formamide for 1.5h;
	With caesium carbonate In N,N-dimethyl-formamide at 25℃;

Reference： [1]Williams, Jodi T.; Bahia, Perdip S.; Kariuki, Benson M.; Spencer, Neil; Philp, Douglas; Snaith, John S. [Journal of Organic Chemistry, 2006, vol. 71, # 6, p. 2460 - 2471]
[2]Williams, Jodi T.; Bahia, Perdip Singh; Snaith, John S. [Organic Letters, 2002, vol. 4, # 21, p. 3727 - 3730]

10
[ 13379-98-1 ]
[ 90149-86-3 ]
[ 686273-56-3 ]

Yield	Reaction Conditions	Operation in experiment
59%	With caesium carbonate In N,N-dimethyl-formamide for 1.5h;
	With caesium carbonate In N,N-dimethyl-formamide at 25℃;

Reference： [1]Williams, Jodi T.; Bahia, Perdip S.; Kariuki, Benson M.; Spencer, Neil; Philp, Douglas; Snaith, John S. [Journal of Organic Chemistry, 2006, vol. 71, # 6, p. 2460 - 2471]
[2]Williams, Jodi T.; Bahia, Perdip Singh; Snaith, John S. [Organic Letters, 2002, vol. 4, # 21, p. 3727 - 3730]

11
[ 13379-98-1 ]
[ 870-63-3 ]
[ 475292-74-1 ]

Yield	Reaction Conditions	Operation in experiment
93%	With caesium carbonate In acetonitrile at 25℃; for 18h;
86%	With caesium carbonate In N,N-dimethyl-formamide for 1.5h;
86%	With caesium carbonate In N,N-dimethyl-formamide at 25℃; for 1.5h;

55%	Stage #1: 3-[N-(4-methylphenylsulfonyl)amino]propan-1-ol With sodium hydride In N,N-dimethyl-formamide; mineral oil for 1h; Stage #2: prenyl bromide In N,N-dimethyl-formamide; mineral oil for 18h;
	Stage #1: 3-[N-(4-methylphenylsulfonyl)amino]propan-1-ol With sodium hydride In N,N-dimethyl-formamide; mineral oil at 0℃; for 1h; Inert atmosphere; Stage #2: prenyl bromide In N,N-dimethyl-formamide; mineral oil at 20℃; for 8h;

Reference： [1]Walker, Stephen M.; Williams, Jodi T.; Russell, Alexander G.; Snaith, John S. [Tetrahedron Letters, 2005, vol. 46, # 39, p. 6611 - 6615]
[2]Williams, Jodi T.; Bahia, Perdip S.; Kariuki, Benson M.; Spencer, Neil; Philp, Douglas; Snaith, John S. [Journal of Organic Chemistry, 2006, vol. 71, # 6, p. 2460 - 2471]
[3]Williams, Jodi T.; Bahia, Perdip Singh; Snaith, John S. [Organic Letters, 2002, vol. 4, # 21, p. 3727 - 3730]
[4]Comito, Robert J.; Finelli, Fernanda G.; Macmillan, David W. C. [Journal of the American Chemical Society, 2013, vol. 135, # 25, p. 9358 - 9361]
[5]Liu, Feng; Liu, Jia-Li; tu, Jia-Lin [Organic Letters, 2020, vol. 22, # 18, p. 7369 - 7372]

12
[ 676-97-1 ]
[ 13379-98-1 ]
[ 892860-54-7 ]

Yield	Reaction Conditions	Operation in experiment
65%	Stage #1: 3-[N-(4-methylphenylsulfonyl)amino]propan-1-ol With sodium hydride In tetrahydrofuran Heating; Stage #2: methylphosphonic acid dichloroanhydride In tetrahydrofuran Heating;

Reference： [1]Dujols, Frederic; Mulliez, Michel [European Journal of Organic Chemistry, 2006, # 8, p. 1959 - 1964]

13
[ 824-72-6 ]
[ 13379-98-1 ]
2-phenyl-3-(toluene-4-sulfonyl)-[1,3,2]oxazaphosphinane 2-oxide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
63%	Stage #1: 3-[N-(4-methylphenylsulfonyl)amino]propan-1-ol With sodium hydride In tetrahydrofuran Heating; Stage #2: P,P-dichlorophenylphosphine oxide In tetrahydrofuran Heating;

Reference： [1]Dujols, Frederic; Mulliez, Michel [European Journal of Organic Chemistry, 2006, # 8, p. 1959 - 1964]

14
[ 7206-98-6 ]
[ 13379-98-1 ]
[ 882053-93-2 ]

Yield	Reaction Conditions	Operation in experiment
66%	With caesium carbonate In N,N-dimethyl-formamide for 1.5h;

Reference： [1]Williams, Jodi T.; Bahia, Perdip S.; Kariuki, Benson M.; Spencer, Neil; Philp, Douglas; Snaith, John S. [Journal of Organic Chemistry, 2006, vol. 71, # 6, p. 2460 - 2471]

15
[ 13379-98-1 ]
[ 90149-87-4 ]
[ 882053-94-3 ]

Yield	Reaction Conditions	Operation in experiment
63%	With caesium carbonate In N,N-dimethyl-formamide for 1.5h;

Reference： [1]Williams, Jodi T.; Bahia, Perdip S.; Kariuki, Benson M.; Spencer, Neil; Philp, Douglas; Snaith, John S. [Journal of Organic Chemistry, 2006, vol. 71, # 6, p. 2460 - 2471]

16
[ 13379-98-1 ]
[ 770-12-7 ]
2-phenoxy-3-(toluene-4-sulfonyl)-[1,3,2]oxazaphosphinane 2-oxide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
59%	Stage #1: 3-[N-(4-methylphenylsulfonyl)amino]propan-1-ol With sodium hydride In tetrahydrofuran Heating; Stage #2: O-phenyl phosphorodichloridate In tetrahydrofuran Heating;

Reference： [1]Dujols, Frederic; Mulliez, Michel [European Journal of Organic Chemistry, 2006, # 8, p. 1959 - 1964]

17
[ 13379-98-1 ]
[ 3355-28-0 ]
[ 882053-90-9 ]

Yield	Reaction Conditions	Operation in experiment
63%	With caesium carbonate In N,N-dimethyl-formamide for 40h;

Reference： [1]Williams, Jodi T.; Bahia, Perdip S.; Kariuki, Benson M.; Spencer, Neil; Philp, Douglas; Snaith, John S. [Journal of Organic Chemistry, 2006, vol. 71, # 6, p. 2460 - 2471]

18
[ 13379-98-1 ]
[ 676-98-2 ]
[ 892860-50-3 ]

Yield	Reaction Conditions	Operation in experiment
70%	Stage #1: 3-[N-(4-methylphenylsulfonyl)amino]propan-1-ol With sodium hydride In tetrahydrofuran for 1h; Heating; Stage #2: methylphosphonothioic dichloride In tetrahydrofuran for 3h; Heating;

Reference： [1]Dujols, Frederic; Mulliez, Michel [European Journal of Organic Chemistry, 2006, # 8, p. 1959 - 1964]

19
[ 13379-98-1 ]
[ 3497-00-5 ]
[ 892860-52-5 ]

Yield	Reaction Conditions	Operation in experiment
61%	Stage #1: 3-[N-(4-methylphenylsulfonyl)amino]propan-1-ol With sodium hydride In tetrahydrofuran Heating; Stage #2: phenylthiophosphonic acid dichloride In tetrahydrofuran Heating;

Reference： [1]Dujols, Frederic; Mulliez, Michel [European Journal of Organic Chemistry, 2006, # 8, p. 1959 - 1964]

20
[ 13379-98-1 ]
[ 18162-48-6 ]
[ 115306-77-9 ]

Yield	Reaction Conditions	Operation in experiment
93%	With 1H-imidazole; dmap In dichloromethane at 0℃; for 2.5h;
78%	With 1H-imidazole; dmap In dichloromethane at 0℃; Inert atmosphere;
	With dmap; triethylamine In dichloromethane at 0 - 20℃; for 16h;

With 1H-imidazole In dichloromethane at 20℃; for 22h;

Reference： [1]Poloukhtine, Andrei; Popik, Vladimir V. [Journal of the American Chemical Society, 2007, vol. 129, # 40, p. 12062 - 12063]
[2]Shohji, Noriaki; Kawaji, Tsuyoshi; Okamoto, Sentaro [Organic Letters, 2011, vol. 13, # 10, p. 2626 - 2629]
[3]Bandini, Marco; Monari, Magda; Romaniello, Alessandro; Tragni, Michele [Chemistry - A European Journal, 2010, vol. 16, # 48, p. 14272 - 14277]
[4]Chen, Anrong; Yu, Houjian; Yan, Jiaqi; Huang, Hanmin [Organic Letters, 2020, vol. 22, # 2, p. 755 - 759]

21
[ 13379-98-1 ]
[ 882054-04-8 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: 63 percent / cesium carbonate / dimethylformamide / 40 h 2: hydrogen; quinoline / palladium on barium sulfate / methanol / 2 h

Reference： [1]Williams, Jodi T.; Bahia, Perdip S.; Kariuki, Benson M.; Spencer, Neil; Philp, Douglas; Snaith, John S. [Journal of Organic Chemistry, 2006, vol. 71, # 6, p. 2460 - 2471]

22
[ 13379-98-1 ]
[ 475292-56-9 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: 86 percent / cesium carbonate / dimethylformamide / 1.5 h 2: 67 percent / pyridinium chlorochromate; celite / CH₂Cl₂ / 0 - 20 °C
	Multi-step reaction with 2 steps 1: 93 percent / Cs₂CO₃ / acetonitrile / 18 h / 25 °C 2: 67 percent / PCC; Celite / CH₂Cl₂ / 2 h / 25 °C
	Multi-step reaction with 2 steps 1: 86 percent / Cs₂CO₃ / dimethylformamide / 1.5 h / 25 °C 2: 67 percent / PCC; celite / CH₂Cl₂ / 2 h / 25 °C

Multi-step reaction with 2 steps 1.1: sodium hydride / mineral oil; N,N-dimethyl-formamide / 1 h 1.2: 18 h 2.1: dimethyl sulfoxide; oxalyl dichloride / dichloromethane / 0.5 h / -78 °C

Reference： [1]Williams, Jodi T.; Bahia, Perdip S.; Kariuki, Benson M.; Spencer, Neil; Philp, Douglas; Snaith, John S. [Journal of Organic Chemistry, 2006, vol. 71, # 6, p. 2460 - 2471]
[2]Walker, Stephen M.; Williams, Jodi T.; Russell, Alexander G.; Snaith, John S. [Tetrahedron Letters, 2005, vol. 46, # 39, p. 6611 - 6615]
[3]Williams, Jodi T.; Bahia, Perdip Singh; Snaith, John S. [Organic Letters, 2002, vol. 4, # 21, p. 3727 - 3730]
[4]Comito, Robert J.; Finelli, Fernanda G.; Macmillan, David W. C. [Journal of the American Chemical Society, 2013, vol. 135, # 25, p. 9358 - 9361]

23
[ 13379-98-1 ]
[ 475292-57-0 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: 62 percent / cesium carbonate / dimethylformamide / 1.5 h 2: 77 percent / pyridinium chlorochromate; celite / CH₂Cl₂ / 0 - 20 °C
	Multi-step reaction with 2 steps 1: Cs₂CO₃ / dimethylformamide / 25 °C 2: PCC; celite / CH₂Cl₂ / 25 °C

Reference： [1]Williams, Jodi T.; Bahia, Perdip S.; Kariuki, Benson M.; Spencer, Neil; Philp, Douglas; Snaith, John S. [Journal of Organic Chemistry, 2006, vol. 71, # 6, p. 2460 - 2471]
[2]Williams, Jodi T.; Bahia, Perdip Singh; Snaith, John S. [Organic Letters, 2002, vol. 4, # 21, p. 3727 - 3730]

24
[ 13379-98-1 ]
[ 475292-58-1 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: 65 percent / cesium carbonate / dimethylformamide / 1.5 h 2: 85 percent / pyridinium chlorochromate; N-methylmorpholine N-oxide; tetrapropylammonium perruthenate / molecular sieves 4 Angstroem / CH₂Cl₂ / 1.25 h
	Multi-step reaction with 2 steps 1: Cs₂CO₃ / dimethylformamide / 25 °C 2: 83 percent / TPAP; NMO; 4 Angstroem molecular sieves / 25 °C

Reference： [1]Williams, Jodi T.; Bahia, Perdip S.; Kariuki, Benson M.; Spencer, Neil; Philp, Douglas; Snaith, John S. [Journal of Organic Chemistry, 2006, vol. 71, # 6, p. 2460 - 2471]
[2]Williams, Jodi T.; Bahia, Perdip Singh; Snaith, John S. [Organic Letters, 2002, vol. 4, # 21, p. 3727 - 3730]

25
[ 13379-98-1 ]
[ 475292-59-2 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: 60 percent / cesium carbonate / dimethylformamide / 1.5 h 2: 67 percent / pyridinium chlorochromate; celite / CH₂Cl₂ / 0 - 20 °C
	Multi-step reaction with 2 steps 1: Cs₂CO₃ / dimethylformamide / 25 °C 2: PCC; celite / CH₂Cl₂ / 25 °C

Reference： [1]Williams, Jodi T.; Bahia, Perdip S.; Kariuki, Benson M.; Spencer, Neil; Philp, Douglas; Snaith, John S. [Journal of Organic Chemistry, 2006, vol. 71, # 6, p. 2460 - 2471]
[2]Williams, Jodi T.; Bahia, Perdip Singh; Snaith, John S. [Organic Letters, 2002, vol. 4, # 21, p. 3727 - 3730]

26
[ 13379-98-1 ]
(3RS,4SR)-3-[(E)-1-ethylprop-1-enyl]-1-(toluene-4-sulfonyl)piperidin-4-ol [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 3 steps 1: 62 percent / cesium carbonate / dimethylformamide / 1.5 h 2: 77 percent / pyridinium chlorochromate; celite / CH₂Cl₂ / 0 - 20 °C 3: hydrochloric acid / CH₂Cl₂ / 16 h / -78 °C
	Multi-step reaction with 3 steps 1: Cs₂CO₃ / dimethylformamide / 25 °C 2: PCC; celite / CH₂Cl₂ / 25 °C 3: HCl / CH₂Cl₂; H₂O / 16 h / -78 °C

Reference： [1]Williams, Jodi T.; Bahia, Perdip S.; Kariuki, Benson M.; Spencer, Neil; Philp, Douglas; Snaith, John S. [Journal of Organic Chemistry, 2006, vol. 71, # 6, p. 2460 - 2471]
[2]Williams, Jodi T.; Bahia, Perdip Singh; Snaith, John S. [Organic Letters, 2002, vol. 4, # 21, p. 3727 - 3730]

27
[ 13379-98-1 ]
(3RS,4RS)-3-(cyclopent-1-enyl)-1-(toluene-4-sulfonyl)piperidin-4-ol [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 3 steps 1: 65 percent / cesium carbonate / dimethylformamide / 1.5 h 2: 85 percent / pyridinium chlorochromate; N-methylmorpholine N-oxide; tetrapropylammonium perruthenate / molecular sieves 4 Angstroem / CH₂Cl₂ / 1.25 h 3: 53 percent / methylaluminum dichloride / CHCl₃; hexane / 16 h / Heating
	Multi-step reaction with 3 steps 1: Cs₂CO₃ / dimethylformamide / 25 °C 2: 83 percent / TPAP; NMO; 4 Angstroem molecular sieves / 25 °C 3: 53 percent / CH₃AlCl₂ / CHCl₃; various solvent(s) / 27 h / 61 °C

Reference： [1]Williams, Jodi T.; Bahia, Perdip S.; Kariuki, Benson M.; Spencer, Neil; Philp, Douglas; Snaith, John S. [Journal of Organic Chemistry, 2006, vol. 71, # 6, p. 2460 - 2471]
[2]Williams, Jodi T.; Bahia, Perdip Singh; Snaith, John S. [Organic Letters, 2002, vol. 4, # 21, p. 3727 - 3730]

28
[ 13379-98-1 ]
(3RS,4SR)-3-(cyclopent-1-enyl)-1-(toluene-4-sulfonyl)piperidin-4-ol [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 3 steps 1: 65 percent / cesium carbonate / dimethylformamide / 1.5 h 2: 85 percent / pyridinium chlorochromate; N-methylmorpholine N-oxide; tetrapropylammonium perruthenate / molecular sieves 4 Angstroem / CH₂Cl₂ / 1.25 h 3: 22 percent / methylaluminum dichloride / CHCl₃; hexane / 16 h / Heating
	Multi-step reaction with 3 steps 1: Cs₂CO₃ / dimethylformamide / 25 °C 2: 83 percent / TPAP; NMO; 4 Angstroem molecular sieves / 25 °C 3: 22 percent / CH₃AlCl₂ / CHCl₃; various solvent(s) / 27 h / 61 °C

Reference： [1]Williams, Jodi T.; Bahia, Perdip S.; Kariuki, Benson M.; Spencer, Neil; Philp, Douglas; Snaith, John S. [Journal of Organic Chemistry, 2006, vol. 71, # 6, p. 2460 - 2471]
[2]Williams, Jodi T.; Bahia, Perdip Singh; Snaith, John S. [Organic Letters, 2002, vol. 4, # 21, p. 3727 - 3730]

29
[ 13379-98-1 ]
[ 475292-60-5 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: 59 percent / cesium carbonate / dimethylformamide / 1.5 h 2: 61 percent / pyridinium chlorochromate; celite / CH₂Cl₂ / 0 - 20 °C
	Multi-step reaction with 2 steps 1: Cs₂CO₃ / dimethylformamide / 25 °C 2: PCC; celite / CH₂Cl₂ / 25 °C

Reference： [1]Williams, Jodi T.; Bahia, Perdip S.; Kariuki, Benson M.; Spencer, Neil; Philp, Douglas; Snaith, John S. [Journal of Organic Chemistry, 2006, vol. 71, # 6, p. 2460 - 2471]
[2]Williams, Jodi T.; Bahia, Perdip Singh; Snaith, John S. [Organic Letters, 2002, vol. 4, # 21, p. 3727 - 3730]

30
[ 13379-98-1 ]
(3RS,4RS)-3-(cyclohex-1-enyl)-1-(toluene-4-sulfonyl)piperidin-4-ol [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 3 steps 1: 60 percent / cesium carbonate / dimethylformamide / 1.5 h 2: 67 percent / pyridinium chlorochromate; celite / CH₂Cl₂ / 0 - 20 °C 3: 74 percent / methylaluminum dichloride / CHCl₃; hexane / 16 h / Heating
	Multi-step reaction with 3 steps 1: Cs₂CO₃ / dimethylformamide / 25 °C 2: PCC; celite / CH₂Cl₂ / 25 °C 3: 74 percent / CH₃AlCl₂ / CHCl₃; various solvent(s) / 27 h / 61 °C

Reference： [1]Williams, Jodi T.; Bahia, Perdip S.; Kariuki, Benson M.; Spencer, Neil; Philp, Douglas; Snaith, John S. [Journal of Organic Chemistry, 2006, vol. 71, # 6, p. 2460 - 2471]
[2]Williams, Jodi T.; Bahia, Perdip Singh; Snaith, John S. [Organic Letters, 2002, vol. 4, # 21, p. 3727 - 3730]

31
[ 13379-98-1 ]
(3RS,4SR)-3-(cyclohex-1-enyl)-1-(toluene-4-sulfonyl)piperidin-4-ol [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 3 steps 1: 60 percent / cesium carbonate / dimethylformamide / 1.5 h 2: 67 percent / pyridinium chlorochromate; celite / CH₂Cl₂ / 0 - 20 °C 3: 4 percent / methylaluminum dichloride / CHCl₃; hexane / 16 h / Heating
	Multi-step reaction with 3 steps 1: Cs₂CO₃ / dimethylformamide / 25 °C 2: PCC; celite / CH₂Cl₂ / 25 °C 3: 4 percent / CH₃AlCl₂ / CHCl₃; various solvent(s) / 27 h / 61 °C

Reference： [1]Williams, Jodi T.; Bahia, Perdip S.; Kariuki, Benson M.; Spencer, Neil; Philp, Douglas; Snaith, John S. [Journal of Organic Chemistry, 2006, vol. 71, # 6, p. 2460 - 2471]
[2]Williams, Jodi T.; Bahia, Perdip Singh; Snaith, John S. [Organic Letters, 2002, vol. 4, # 21, p. 3727 - 3730]

32
[ 13379-98-1 ]
(3RS,4RS)-3-(cyclohept-1-enyl)-1-(toluene-4-sulfonyl)piperidin-4-ol [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 3 steps 1: 59 percent / cesium carbonate / dimethylformamide / 1.5 h 2: 61 percent / pyridinium chlorochromate; celite / CH₂Cl₂ / 0 - 20 °C 3: 61 percent / methylaluminum dichloride / CHCl₃; hexane / 16 h / Heating
	Multi-step reaction with 3 steps 1: Cs₂CO₃ / dimethylformamide / 25 °C 2: PCC; celite / CH₂Cl₂ / 25 °C 3: 61 percent / CH₃AlCl₂ / CHCl₃; various solvent(s) / 27 h / 61 °C

Reference： [1]Williams, Jodi T.; Bahia, Perdip S.; Kariuki, Benson M.; Spencer, Neil; Philp, Douglas; Snaith, John S. [Journal of Organic Chemistry, 2006, vol. 71, # 6, p. 2460 - 2471]
[2]Williams, Jodi T.; Bahia, Perdip Singh; Snaith, John S. [Organic Letters, 2002, vol. 4, # 21, p. 3727 - 3730]

33
[ 13379-98-1 ]
(3RS,4SR)-3-(cyclohept-1-enyl)-1-(toluene-4-sulfonyl)piperidin-4-ol [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 3 steps 1: 59 percent / cesium carbonate / dimethylformamide / 1.5 h 2: 61 percent / pyridinium chlorochromate; celite / CH₂Cl₂ / 0 - 20 °C 3: 20 percent / methylaluminum dichloride / CHCl₃; hexane / 16 h / Heating
	Multi-step reaction with 3 steps 1: Cs₂CO₃ / dimethylformamide / 25 °C 2: PCC; celite / CH₂Cl₂ / 25 °C 3: 20 percent / CH₃AlCl₂ / CHCl₃; various solvent(s) / 27 h / 61 °C

Reference： [1]Williams, Jodi T.; Bahia, Perdip S.; Kariuki, Benson M.; Spencer, Neil; Philp, Douglas; Snaith, John S. [Journal of Organic Chemistry, 2006, vol. 71, # 6, p. 2460 - 2471]
[2]Williams, Jodi T.; Bahia, Perdip Singh; Snaith, John S. [Organic Letters, 2002, vol. 4, # 21, p. 3727 - 3730]

34
[ 13379-98-1 ]
[ 882054-05-9 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: 63 percent / cesium carbonate / dimethylformamide / 40 h 2: hydrogen; quinoline / palladium on barium sulfate / methanol / 2 h

Reference： [1]Williams, Jodi T.; Bahia, Perdip S.; Kariuki, Benson M.; Spencer, Neil; Philp, Douglas; Snaith, John S. [Journal of Organic Chemistry, 2006, vol. 71, # 6, p. 2460 - 2471]

35
[ 13379-98-1 ]
(3RS,4SR)-3-[(Z)-1-ethylprop-1-enyl]-1-(toluene-4-sulfonyl)piperidin-4-ol [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 3 steps 1: 62 percent / cesium carbonate / dimethylformamide / 1.5 h 2: 77 percent / pyridinium chlorochromate; celite / CH₂Cl₂ / 0 - 20 °C 3: hydrochloric acid / CH₂Cl₂ / 16 h / -78 °C
	Multi-step reaction with 3 steps 1: Cs₂CO₃ / dimethylformamide / 25 °C 2: PCC; celite / CH₂Cl₂ / 25 °C 3: HCl / CH₂Cl₂; H₂O / 16 h / -78 °C

Reference： [1]Williams, Jodi T.; Bahia, Perdip S.; Kariuki, Benson M.; Spencer, Neil; Philp, Douglas; Snaith, John S. [Journal of Organic Chemistry, 2006, vol. 71, # 6, p. 2460 - 2471]
[2]Williams, Jodi T.; Bahia, Perdip Singh; Snaith, John S. [Organic Letters, 2002, vol. 4, # 21, p. 3727 - 3730]

36
[ 13379-98-1 ]
[ 321835-85-2 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 4 steps 1: 100 percent / Et₃N / CHCl₃ / 0.5 h / 0 °C 2: 82 percent / Et₃N / acetonitrile / 4 h / Heating 3: 90 percent / Cu(Ac)2 / 24 h / 20 °C 4: 90 percent / Et₃N / CHCl₃ / 0.5 h / 0 °C

Reference： [1]Drandarov, Konstantin; Guggisberg, Armin; Hesse, Manfred [Helvetica Chimica Acta, 2002, vol. 85, # 4, p. 979 - 989]

37
[ 13379-98-1 ]
[ 444119-35-1 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 3 steps 1: 100 percent / Et₃N / CHCl₃ / 0.5 h / 0 °C 2: 82 percent / Et₃N / acetonitrile / 4 h / Heating 3: 90 percent / Cu(Ac)2 / 24 h / 20 °C

Reference： [1]Drandarov, Konstantin; Guggisberg, Armin; Hesse, Manfred [Helvetica Chimica Acta, 2002, vol. 85, # 4, p. 979 - 989]

38
[ 13379-98-1 ]
[ 373360-25-9 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 5 steps 1: 100 percent / Et₃N / CHCl₃ / 0.5 h / 0 °C 2: 82 percent / Et₃N / acetonitrile / 4 h / Heating 3: 90 percent / Cu(Ac)2 / 24 h / 20 °C 4: 90 percent / Et₃N / CHCl₃ / 0.5 h / 0 °C 5: 83 percent / Cs₂CO₃ / dimethylformamide

Reference： [1]Drandarov, Konstantin; Guggisberg, Armin; Hesse, Manfred [Helvetica Chimica Acta, 2002, vol. 85, # 4, p. 979 - 989]

39
[ 13379-98-1 ]
[ 444119-34-0 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 3 steps 1: 100 percent / Et₃N / CHCl₃ / 0.5 h / 0 °C 2: 79 percent / Et₃N / acetonitrile / 4 h / Heating 3: 87 percent / Cu(Ac)2 / 24 h / 20 °C

Reference： [1]Drandarov, Konstantin; Guggisberg, Armin; Hesse, Manfred [Helvetica Chimica Acta, 2002, vol. 85, # 4, p. 979 - 989]

40
[ 13379-98-1 ]
[ 444119-36-2 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 4 steps 1: 100 percent / Et₃N / CHCl₃ / 0.5 h / 0 °C 2: 79 percent / Et₃N / acetonitrile / 4 h / Heating 3: 87 percent / Cu(Ac)2 / 24 h / 20 °C 4: 92 percent / Et₃N / CHCl₃ / 0.5 h / 0 °C

Reference： [1]Drandarov, Konstantin; Guggisberg, Armin; Hesse, Manfred [Helvetica Chimica Acta, 2002, vol. 85, # 4, p. 979 - 989]

41
[ 13379-98-1 ]
[ 444119-37-3 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 5 steps 1: 100 percent / Et₃N / CHCl₃ / 0.5 h / 0 °C 2: 79 percent / Et₃N / acetonitrile / 4 h / Heating 3: 87 percent / Cu(Ac)2 / 24 h / 20 °C 4: 92 percent / Et₃N / CHCl₃ / 0.5 h / 0 °C 5: 75 percent / Cs₂CO₃ / dimethylformamide

Reference： [1]Drandarov, Konstantin; Guggisberg, Armin; Hesse, Manfred [Helvetica Chimica Acta, 2002, vol. 85, # 4, p. 979 - 989]

42
[ 13379-98-1 ]
[ 89578-72-3 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: 95 percent / p-TsOH*H₂O / diethyl ether / 3 h 2: 1.) KH; 2.) HCl / 1.) DMF-mineral oil, 2.5 h, 50 deg C; 2.) MeOH, 1.5 h, RT

Reference： [1]Bailey, Thomas R.; Garigipati, Ravi S.; Morton, Judith A.; Weinreb, Steven M. [Journal of the American Chemical Society, 1984, vol. 106, # 11, p. 3240 - 3245]

43
[ 13379-98-1 ]
[ 89578-75-6 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 3 steps 1: pyridine / CH₂Cl₂ / 0.33 h / 0 °C 2: 99 percent / diisopropylethylamine / CH₂Cl₂ / 4 h / Ambient temperature 3: 100 percent / aq. LiOH / methanol / 15 h / Ambient temperature

Reference： [1]Bailey, Thomas R.; Garigipati, Ravi S.; Morton, Judith A.; Weinreb, Steven M. [Journal of the American Chemical Society, 1984, vol. 106, # 11, p. 3240 - 3245]

44
[ 13379-98-1 ]
[ 89578-74-5 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: pyridine / CH₂Cl₂ / 0.33 h / 0 °C 2: 99 percent / diisopropylethylamine / CH₂Cl₂ / 4 h / Ambient temperature

Reference： [1]Bailey, Thomas R.; Garigipati, Ravi S.; Morton, Judith A.; Weinreb, Steven M. [Journal of the American Chemical Society, 1984, vol. 106, # 11, p. 3240 - 3245]

45
[ 13379-98-1 ]
[ 89578-73-4 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 3 steps 1: 95 percent / p-TsOH*H₂O / diethyl ether / 3 h 2: 1.) KH; 2.) HCl / 1.) DMF-mineral oil, 2.5 h, 50 deg C; 2.) MeOH, 1.5 h, RT 3: 95 percent / pyridine / CH₂Cl₂ / 0.25 h / 0 °C

Reference： [1]Bailey, Thomas R.; Garigipati, Ravi S.; Morton, Judith A.; Weinreb, Steven M. [Journal of the American Chemical Society, 1984, vol. 106, # 11, p. 3240 - 3245]

46
[ 13379-98-1 ]
[ 89578-78-9 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 7 steps 1: pyridine / CH₂Cl₂ / 0.33 h / 0 °C 2: 99 percent / diisopropylethylamine / CH₂Cl₂ / 4 h / Ambient temperature 3: 100 percent / aq. LiOH / methanol / 15 h / Ambient temperature 4: 1-cyclohexyl-3-(2-morpholinoethyl)carbodiimide metho-p-toluenesulfonate / CH₂Cl₂ / 45 h 5: 82 percent / dimethylformamide / 18 h / -20 °C 6: 80 percent / Et₃N / CH₂Cl₂ / 1 h / -15 - 5 °C 7: 58 percent / K₂CO₃ / acetonitrile / 24 h / Heating

Reference： [1]Bailey, Thomas R.; Garigipati, Ravi S.; Morton, Judith A.; Weinreb, Steven M. [Journal of the American Chemical Society, 1984, vol. 106, # 11, p. 3240 - 3245]

47
[ 13379-98-1 ]
[ 89578-76-7 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 5 steps 1: pyridine / CH₂Cl₂ / 0.33 h / 0 °C 2: 99 percent / diisopropylethylamine / CH₂Cl₂ / 4 h / Ambient temperature 3: 100 percent / aq. LiOH / methanol / 15 h / Ambient temperature 4: 1-cyclohexyl-3-(2-morpholinoethyl)carbodiimide metho-p-toluenesulfonate / CH₂Cl₂ / 45 h 5: 82 percent / dimethylformamide / 18 h / -20 °C

Reference： [1]Bailey, Thomas R.; Garigipati, Ravi S.; Morton, Judith A.; Weinreb, Steven M. [Journal of the American Chemical Society, 1984, vol. 106, # 11, p. 3240 - 3245]

48
[ 13379-98-1 ]
[ 89578-83-6 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 4 steps 1: pyridine / CH₂Cl₂ / 0.33 h / 0 °C 2: 99 percent / diisopropylethylamine / CH₂Cl₂ / 4 h / Ambient temperature 3: 100 percent / aq. LiOH / methanol / 15 h / Ambient temperature 4: 1-cyclohexyl-3-(2-morpholinoethyl)carbodiimide metho-p-toluenesulfonate / CH₂Cl₂ / 45 h

Reference： [1]Bailey, Thomas R.; Garigipati, Ravi S.; Morton, Judith A.; Weinreb, Steven M. [Journal of the American Chemical Society, 1984, vol. 106, # 11, p. 3240 - 3245]

49
[ 13379-98-1 ]
[ 89578-77-8 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 6 steps 1: pyridine / CH₂Cl₂ / 0.33 h / 0 °C 2: 99 percent / diisopropylethylamine / CH₂Cl₂ / 4 h / Ambient temperature 3: 100 percent / aq. LiOH / methanol / 15 h / Ambient temperature 4: 1-cyclohexyl-3-(2-morpholinoethyl)carbodiimide metho-p-toluenesulfonate / CH₂Cl₂ / 45 h 5: 82 percent / dimethylformamide / 18 h / -20 °C 6: 80 percent / Et₃N / CH₂Cl₂ / 1 h / -15 - 5 °C

Reference： [1]Bailey, Thomas R.; Garigipati, Ravi S.; Morton, Judith A.; Weinreb, Steven M. [Journal of the American Chemical Society, 1984, vol. 106, # 11, p. 3240 - 3245]

50
[ 13379-98-1 ]
[ 89596-61-2 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 4 steps 1: 95 percent / p-TsOH*H₂O / diethyl ether / 3 h 2: 1.) KH; 2.) HCl / 1.) DMF-mineral oil, 2.5 h, 50 deg C; 2.) MeOH, 1.5 h, RT 3: 95 percent / pyridine / CH₂Cl₂ / 0.25 h / 0 °C 4: 70 percent / diisopropylethylamine / CH₂Cl₂ / 13 h / Ambient temperature

Reference： [1]Bailey, Thomas R.; Garigipati, Ravi S.; Morton, Judith A.; Weinreb, Steven M. [Journal of the American Chemical Society, 1984, vol. 106, # 11, p. 3240 - 3245]

51
[ 13379-98-1 ]
[ 109774-74-5 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 5 steps 2: 79 percent / K₂CO₃ / acetonitrile / 24 h / 80 °C 3: 90 percent / MeOH / pTsOH / 1 h / Ambient temperature 4: 98 percent / Et₃N / CH₂Cl₂ / 2 h / -78 - 25 °C 5: 65 percent / Cs₂CO₃ / dimethylformamide / 7 h / 80 °C

Reference： [1]Heyer, Dennis; Lehn, Jean-Marie [Tetrahedron Letters, 1986, vol. 27, # 48, p. 5869 - 5872]

52
[ 13379-98-1 ]
[ 109774-73-4 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 3 steps 2: 79 percent / K₂CO₃ / acetonitrile / 24 h / 80 °C 3: 90 percent / MeOH / pTsOH / 1 h / Ambient temperature

Reference： [1]Heyer, Dennis; Lehn, Jean-Marie [Tetrahedron Letters, 1986, vol. 27, # 48, p. 5869 - 5872]

53
[ 13379-98-1 ]
[ 109789-74-4 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 4 steps 2: 79 percent / K₂CO₃ / acetonitrile / 24 h / 80 °C 3: 90 percent / MeOH / pTsOH / 1 h / Ambient temperature 4: 98 percent / Et₃N / CH₂Cl₂ / 2 h / -78 - 25 °C

Reference： [1]Heyer, Dennis; Lehn, Jean-Marie [Tetrahedron Letters, 1986, vol. 27, # 48, p. 5869 - 5872]

54
[ 13379-98-1 ]
[ 3245-96-3 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: aq. NaOH / Heating 2: PBr₃ / benzene

Reference： [1]Augstein,J. et al. [Journal of Medicinal Chemistry, 1965, vol. 8, p. 356 - 367]

55
[ 13379-98-1 ]
[ 47473-89-2 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: HBr / acetic acid

Reference： [1]Augstein,J. et al. [Journal of Medicinal Chemistry, 1965, vol. 8, p. 356 - 367]

56
[ 13379-98-1 ]
[ 47528-43-8 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 3 steps 1: aq. NaOH / Heating 2: PBr₃ / benzene

Reference： [1]Augstein,J. et al. [Journal of Medicinal Chemistry, 1965, vol. 8, p. 356 - 367]

57
[ 1125-88-8 ]
[ 13379-98-1 ]
[ 107273-07-4 ]

Yield	Reaction Conditions	Operation in experiment
	With camphor-10-sulfonic acid In 1,2-dichloro-ethane at 20 - 70℃;

Reference： [1]Zhao, Yu-Jun; Loh, Teck-Peng [Journal of the American Chemical Society, 2008, vol. 130, # 30, p. 10024 - 10029]

58
[ 50-00-0 ]
[ 13379-98-1 ]
[ 7344-11-8 ]

Yield	Reaction Conditions	Operation in experiment
94%	With amberlyst-15 In dichloromethane at 20℃; for 2h; Inert atmosphere; Molecular sieve;

Reference： [1]Location in patent: experimental part Bates, Roderick W.; Lu, Yongna; Cai, Melody Peiling [Tetrahedron, 2009, vol. 65, # 37, p. 7852 - 7858]

59
[ 13379-98-1 ]
[ 100-52-7 ]
[ 107273-07-4 ]

Yield	Reaction Conditions	Operation in experiment
91%	With amberlyst-15 In dichloromethane at 20℃; for 2h; Inert atmosphere; Molecular sieve;

Reference： [1]Location in patent: experimental part Bates, Roderick W.; Lu, Yongna; Cai, Melody Peiling [Tetrahedron, 2009, vol. 65, # 37, p. 7852 - 7858]

60
[ 13379-98-1 ]
[ 75-07-0 ]
[ 1190398-19-6 ]

Yield	Reaction Conditions	Operation in experiment
82%	With amberlyst-15 In dichloromethane at 20℃; for 2h; Inert atmosphere; Molecular sieve;

Reference： [1]Location in patent: experimental part Bates, Roderick W.; Lu, Yongna; Cai, Melody Peiling [Tetrahedron, 2009, vol. 65, # 37, p. 7852 - 7858]

61
[ 13379-98-1 ]
[ 123-38-6 ]
[ 1190398-20-9 ]

Yield	Reaction Conditions	Operation in experiment
100%	With amberlyst-15 In dichloromethane at 20℃; for 2h; Inert atmosphere; Molecular sieve;

Reference： [1]Location in patent: experimental part Bates, Roderick W.; Lu, Yongna; Cai, Melody Peiling [Tetrahedron, 2009, vol. 65, # 37, p. 7852 - 7858]

62
[ 34414-28-3 ]
[ 13379-98-1 ]
[ 1254356-81-4 ]

Yield	Reaction Conditions	Operation in experiment
85%	Stage #1: 3-[N-(4-methylphenylsulfonyl)amino]propan-1-ol With caesium carbonate In acetonitrile at 20℃; for 0.5h; Stage #2: (E)-1-chloro-4-acetoxybut-2-ene With tetra-(n-butyl)ammonium iodide In acetonitrile at 0 - 20℃; for 12h;

Reference： [1]Ragoussi, Maria-Eleni; Walker, Stephen M.; Piccanello, Andrea; Kariuki, Benson M.; Horton, Peter N.; Spencer, Neil; Snaith, John S. [Journal of Organic Chemistry, 2010, vol. 75, # 21, p. 7347 - 7357]

63
[ 13379-98-1 ]
[ 607389-95-7 ]
[ 1254356-85-8 ]

Yield	Reaction Conditions	Operation in experiment
80%	Stage #1: 3-[N-(4-methylphenylsulfonyl)amino]propan-1-ol With caesium carbonate In acetonitrile at 20℃; for 0.5h; Stage #2: (E)-1-acetoxy-4-chloro-2-[(triethyl)silyl]but-2-ene With tetra-(n-butyl)ammonium iodide In acetonitrile at 0 - 20℃; for 12h;

Reference： [1]Location in patent: experimental part Ragoussi, Maria-Eleni; Walker, Stephen M.; Piccanello, Andrea; Kariuki, Benson M.; Horton, Peter N.; Spencer, Neil; Snaith, John S. [Journal of Organic Chemistry, 2010, vol. 75, # 21, p. 7347 - 7357]

64
[ 1663-39-4 ]
[ 13379-98-1 ]
[ 1265900-35-3 ]

Yield	Reaction Conditions	Operation in experiment
38%	With dichloro bis(acetonitrile) palladium(II) In 1,2-dimethoxyethane at 40℃; for 16h; Inert atmosphere;

Reference： [1]Elliott, Luke D.; Wrigglesworth, Joe W.; Cox, Brian; Lloyd-Jones, Guy C.; Booker-Milburn, Kevin I. [Organic Letters, 2011, vol. 13, # 4, p. 728 - 731]

65
[ 141-32-2 ]
[ 13379-98-1 ]
[ 1265900-33-1 ]

Yield	Reaction Conditions	Operation in experiment
83%	With dichloro bis(acetonitrile) palladium(II) In 1,2-dimethoxyethane at 30℃; for 21h; Inert atmosphere;

Reference： [1]Elliott, Luke D.; Wrigglesworth, Joe W.; Cox, Brian; Lloyd-Jones, Guy C.; Booker-Milburn, Kevin I. [Organic Letters, 2011, vol. 13, # 4, p. 728 - 731]

66
[ 13379-98-1 ]
[ 292638-85-8 ]
[ 1265900-37-5 ]

Yield	Reaction Conditions	Operation in experiment
71%	With dichloro bis(acetonitrile) palladium(II) In 1,2-dimethoxyethane at 40℃; for 6h; Inert atmosphere;

Reference： [1]Elliott, Luke D.; Wrigglesworth, Joe W.; Cox, Brian; Lloyd-Jones, Guy C.; Booker-Milburn, Kevin I. [Organic Letters, 2011, vol. 13, # 4, p. 728 - 731]

67
[ 13379-98-1 ]
[ 79-10-7 ]
[ 1265900-39-7 ]

Yield	Reaction Conditions	Operation in experiment
32%	With dichloro bis(acetonitrile) palladium(II) In 1,2-dimethoxyethane at 40℃; for 6h; Inert atmosphere;

Reference： [1]Elliott, Luke D.; Wrigglesworth, Joe W.; Cox, Brian; Lloyd-Jones, Guy C.; Booker-Milburn, Kevin I. [Organic Letters, 2011, vol. 13, # 4, p. 728 - 731]

68
[ 13379-98-1 ]
[ 1296794-23-4 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1.1: 1H-imidazole; dmap / dichloromethane / 0 °C / Inert atmosphere 2.1: sodium hydride / tetrahydrofuran; N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere 2.2: 0 - 20 °C / Inert atmosphere

Reference： [1]Shohji, Noriaki; Kawaji, Tsuyoshi; Okamoto, Sentaro [Organic Letters, 2011, vol. 13, # 10, p. 2626 - 2629]

Purity	Size	Price	VIP Price	USA Stock *0-1 Day	Global Stock *5-7 Days	Quantity
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CAS No. :	13379-98-1	MDL No. :	MFCD00458992
Formula :	C₁₀H₁₅NO₃S	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	OXBINBPGHTWHKS-UHFFFAOYSA-N
M.W :	229.30	Pubchem ID :	2180655
Synonyms :

Num. heavy atoms :	15
Num. arom. heavy atoms :	6
Fraction Csp3 :	0.4
Num. rotatable bonds :	5
Num. H-bond acceptors :	4.0
Num. H-bond donors :	2.0
Molar Refractivity :	58.08
TPSA :	74.78 Å²

GI absorption :	High
BBB permeant :	No
P-gp substrate :	No
CYP1A2 inhibitor :	No
CYP2C19 inhibitor :	No
CYP2C9 inhibitor :	No
CYP2D6 inhibitor :	No
CYP3A4 inhibitor :	No
Log Kp (skin permeation) :	-7.05 cm/s

Log Po/w (iLOGP) :	1.7
Log Po/w (XLOGP3) :	0.92
Log Po/w (WLOGP) :	1.74
Log Po/w (MLOGP) :	0.74
Log Po/w (SILICOS-IT) :	0.92
Consensus Log Po/w :	1.2

[ CAS No. 13379-98-1 ]

Quality Control of [ 13379-98-1 ]

Related Doc. of [ 13379-98-1 ]

Product Details of [ 13379-98-1 ]

Calculated chemistry of [ 13379-98-1 ]

Physicochemical Properties

Pharmacokinetics

Lipophilicity

Druglikeness

Water Solubility

Medicinal Chemistry

Safety of [ 13379-98-1 ]

Application In Synthesis of [ 13379-98-1 ]

[ 13379-98-1 ] Synthesis Path-Downstream 1~68

Related Functional Groups of
[ 13379-98-1 ]

Aryls

Alcohols

Amines

Sulfamides

Precautionary Statements-General

Prevention

Response

Storage

Disposal

Physical hazards

Health hazards

Environmental hazards

Inquiry

Lipinski :	0.0
Ghose :	None
Veber :	0.0
Egan :	0.0
Muegge :	0.0
Bioavailability Score :	0.55

Log S (ESOL) :	-1.81
Solubility :	3.57 mg/ml ; 0.0156 mol/l
Class :	Very soluble
Log S (Ali) :	-2.08
Solubility :	1.92 mg/ml ; 0.00839 mol/l
Class :	Soluble
Log S (SILICOS-IT) :	-3.41
Solubility :	0.0896 mg/ml ; 0.000391 mol/l
Class :	Soluble

PAINS :	0.0 alert
Brenk :	0.0 alert
Leadlikeness :	1.0
Synthetic accessibility :	2.14

Signal Word:	Warning	Class:	N/A
Precautionary Statements:	P261-P280-P301+P312-P302+P352-P305+P351+P338	UN#:	N/A
Hazard Statements:	H302-H315-H319-H335	Packing Group:	N/A
GHS Pictogram:

Precautionary Statements-General
Code	Phrase
P101	If medical advice is needed,have product container or label at hand.
P102	Keep out of reach of children.
P103	Read label before use
Prevention
Code	Phrase
P201	Obtain special instructions before use.
P202	Do not handle until all safety precautions have been read and understood.
P210	Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P211	Do not spray on an open flame or other ignition source.
P220	Keep/Store away from clothing/combustible materials.
P221	Take any precaution to avoid mixing with combustibles
P222	Do not allow contact with air.
P223	Keep away from any possible contact with water, because of violent reaction and possible flash fire.
P230	Keep wetted
P231	Handle under inert gas.
P232	Protect from moisture.
P233	Keep container tightly closed.
P234	Keep only in original container.
P235	Keep cool
P240	Ground/bond container and receiving equipment.
P241	Use explosion-proof electrical/ventilating/lighting/equipment.
P242	Use only non-sparking tools.
P243	Take precautionary measures against static discharge.
P244	Keep reduction valves free from grease and oil.
P250	Do not subject to grinding/shock/friction.
P251	Pressurized container: Do not pierce or burn, even after use.
P260	Do not breathe dust/fume/gas/mist/vapours/spray.
P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P262	Do not get in eyes, on skin, or on clothing.
P263	Avoid contact during pregnancy/while nursing.
P264	Wash hands thoroughly after handling.
P265	Wash skin thouroughly after handling.
P270	Do not eat, drink or smoke when using this product.
P271	Use only outdoors or in a well-ventilated area.
P272	Contaminated work clothing should not be allowed out of the workplace.
P273	Avoid release to the environment.
P280	Wear protective gloves/protective clothing/eye protection/face protection.
P281	Use personal protective equipment as required.
P282	Wear cold insulating gloves/face shield/eye protection.
P283	Wear fire/flame resistant/retardant clothing.
P284	Wear respiratory protection.
P285	In case of inadequate ventilation wear respiratory protection.
P231 + P232	Handle under inert gas. Protect from moisture.
P235 + P410	Keep cool. Protect from sunlight.
Response
Code	Phrase
P301	IF SWALLOWED:
P304	IF INHALED:
P305	IF IN EYES:
P306	IF ON CLOTHING:
P307	IF exposed:
P308	IF exposed or concerned:
P309	IF exposed or if you feel unwell:
P310	Immediately call a POISON CENTER or doctor/physician.
P311	Call a POISON CENTER or doctor/physician.
P312	Call a POISON CENTER or doctor/physician if you feel unwell.
P313	Get medical advice/attention.
P314	Get medical advice/attention if you feel unwell.
P315	Get immediate medical advice/attention.
P320
P302 + P352	IF ON SKIN: wash with plenty of soap and water.
P321
P322
P330	Rinse mouth.
P331	Do NOT induce vomiting.
P332	IF SKIN irritation occurs:
P333	If skin irritation or rash occurs:
P334	Immerse in cool water/wrap n wet bandages.
P335	Brush off loose particles from skin.
P336	Thaw frosted parts with lukewarm water. Do not rub affected area.
P337	If eye irritation persists:
P338	Remove contact lenses, if present and easy to do. Continue rinsing.
P340	Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

[ CAS No. 13379-98-1 ]

Quality Control of [ 13379-98-1 ]

Related Doc. of [ 13379-98-1 ]

Product Details of [ 13379-98-1 ]

Calculated chemistry of [ 13379-98-1 ]

Physicochemical Properties

Pharmacokinetics

Lipophilicity

Druglikeness

Water Solubility

Medicinal Chemistry

Safety of [ 13379-98-1 ]

Application In Synthesis of [ 13379-98-1 ]

[ 13379-98-1 ] Synthesis Path-Downstream 1~68

Related Functional Groups of [ 13379-98-1 ]

Aryls

Alcohols

Amines

Sulfamides

Precautionary Statements-General

Prevention

Response

Storage

Disposal

Physical hazards

Health hazards

Environmental hazards

Inquiry

Related Functional Groups of
[ 13379-98-1 ]