1337916-18-3|(6-Bromonaphthalen-2-yl)boronic acid| Ambeed

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CAS No. :	1337916-18-3
Formula :	C₁₀H₈BBrO₂
M.W :	250.88
SMILES Code :	BrC1=CC2=CC=C(B(O)O)C=C2C=C1
MDL No. :	MFCD18410711
InChI Key :	JOSJENCQBZHUDM-UHFFFAOYSA-N
Pubchem ID :	58461093

GHS Pictogram:
Signal Word:	Warning
Hazard Statements:	H302-H315-H319
Precautionary Statements:	P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330

Yield	Reaction Conditions	Operation in experiment
90%	With tetrakis(triphenylphosphine) palladium(0); caesium carbonate; In ethanol; water; toluene; at 90℃; for 24h;	A mixed solution of toluene (80 mL), ethanol (40 mL), 2M Cs2CO3 aqueous solution (80 mL) in a 500 ml two-necked flask was added for 30 minutes, and then added.<strong>[689291-89-2]5-bromo-2-iodobenzaldehyde</strong> (3.10 g, 10 mmol),With 6-bromo-2-naphthalene boronic acid (2.8 g, 11 mmol),Pd(PPh3)4 (230 mg, 0.2 mmol).Stir for 24 hours by heating to 90 C.Extracted with dichloromethane, washed with water, dried over anhydrous sodium sulfate and filtered.After concentration, 3.5 g of the product was obtained by column chromatography, yield 90%.
82%	With tetrakis(triphenylphosphine) palladium(0); potassium carbonate; In ethanol; water; toluene; at 80℃; for 24h;Sonication;	Into a 500ml two-necked flask feed toluene (80mL), ethanol (40mL), 2Μ K2C03 aqueous solution (80mL) mixed solution for 30 minutes after ultrasonication added <strong>[689291-89-2]5-bromo-2-iodobenzaldehyde</strong> (3.10g, 10mmol), with 6-bromo-2-naphthaleneboronic acid (2.8g, 11mmol), Pd(PPh3) 4 (230 mg, 0.2mmol). Heat at 80 C for 24 hours, extract with dichloromethane, and wash with water, dry with anhydrous sodium sulfate, filtered, concentrated and passed through column chromatography and then obtained product 3.2g, yield 82%.

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P378
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P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
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P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
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P370 + P378	In case of fire:
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P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
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P401
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P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

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CAS No.: 1337916-18-3

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CAS No.: 1337916-18-3

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Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed